Results 71 to 80 of about 14,827 (208)
Andrology, EarlyView.ABSTRACT Background Hyperlipidemia‐related erectile dysfunction (HLED) responds poorly to first‐line treatments such as phosphodiesterase type 5 inhibitors (PDE5Is), emphasizing the need for alternative therapeutic strategies. Rutaecarpine (RUT), a bioactive alkaloid, exhibits significant anti‐inflammatory and anti‐fibrotic effects.
Bocheng Tu +9 more
wiley +1 more source
Journal of Veterinary Pharmacology and Therapeutics, EarlyView.ABSTRACT Because P‐glycoprotein (P‐gp) influences the disposition of substrate drugs, regulatory agencies recommend ascertaining the P‐gp substrate status of active pharmaceutical ingredients (API's) intended for humans. Transwell‐based assays using P‐gp‐overexpressing human cell lines are routinely used to predict the API's P‐gp substrate status ...
K. L. Mealey, N. S. Burke
wiley +1 more source
Inhibitory effects of apomorphine and atropine and their combination on myopia in chicks
, 2004 PURPOSE: The inhibitory effect of apomorphine on form-deprivation myopia implies a role for dopaminergic pathways in eye growth; however, the effect of apomorphine on lens-induced changes has not been studied. Our study filled this deficiency.
Wildsoet, Christine F. +1 more
core
Theranostic liposomes loaded with quantum dots and apomorphine for brain targeting and bioimaging
, 2012 Chih-Jen Wen1,*, Li-Wen Zhang2,*, Saleh A Al-Suwayeh3, Tzu-Chen Yen1, Jia-You Fang2,4 1Molecular Imaging Center, Chang Gung Memorial Hospital, Gueishan, Taoyuan, Taiwan; 2Pharmaceutics Laboratory, Graduate Institute of Natural Products, Chang Gung ...
Wen CJ +4 more
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The Pharmacological Properties and Therapeutic Use of Apomorphine
Molecules, 2012 Apomorphine <strong>(</strong>APO) is an aporphine derivative used in human and veterinary medicine. APO activates D<sub>1</sub>, D<sub>2S</sub>, D<sub>2L</sub>, D<sub>3</sub>, D<sub>4</
Samo Ribarič
doaj +1 more source
The Journal of Physiology, EarlyView.Abstract figure legend Paracetamol (acetaminophen) is commonly taken during pregnancy for pain and fever. To gain a more comprehensive understanding of paracetamol's effects during pregnancy, several elements need to be examined including the transfer of paracetamol across the placenta and into the developing brain, the short‐ and long‐term effects of ...
Yifan Huang, Liam Koehn
wiley +1 more source
, 2001 Studies apomorphine autoxidation by recording the formation of a neuromelanin product. Investigation of apomorphine toxicity on cultures of rat glioma C6 cells and primary cultures of neurons; Role of thiol reagents on apomorphine autoxidation.CAPES ...
Daval, Jean-Luc +3 more
core
Neurology and TherapyIntroduction Parkinson’s disease is the second most common neurodegenerative disorder. In advanced Parkinson’s disease, subcutaneous (SC) infusion therapies represent minimally invasive and reversible treatment options.
Marc Vérin +9 more
doaj +1 more source
The Journal of Physiology, EarlyView.Abstract figure legend Suboptimal maternal nutrition alters placental and developing blood–brain barrier (BBB) protective function and is associated with increased fetal brain vulnerability. In the placenta, nutritional adversity may reduce the exchange surface area and promote meta‐inflammation, compromising barrier efficiency in a model‐ and context ...
Kristin L. Connor +4 more
wiley +1 more source
Food Frontiers, Volume 7, Issue 6, November 2026.ABSTRACT Epilepsy is the most disabling neurological disease that affects all economic classes, age groups, regions, and races. Although many antiseizure drugs are approved for epilepsy treatment, they fail to work in about 30%–40% of patients. Thus, there is a great need to identify better pharmacological agents to treat epilepsy.
Janakiraman Pillai Udaiyappan +3 more
wiley +1 more source