Results 81 to 90 of about 21,736 (211)

Toll‐like receptor 4 mediates lipopolysaccharide‐induced emesis

British Journal of Pharmacology, EarlyView.
Background and Purpose Lipopolysaccharide (LPS) induces inflammation and sepsis through Toll‐like receptor 4 (TLR4) activation. Common laboratory animals do not exhibit emesis, but administration of LPS in piglets, cats, and dogs induces emesis via peripheral mechanisms.
Luping Liu, Zengbing Lu, Julia Yuen Hang Liu, Man Piu Ngan, Kai‐Hei Tse, John Anthony Rudd   +5 more
wiley   +1 more source

Combination of CDNF and Deep Brain Stimulation Decreases Neurological Deficits in Late-stage Model Parkinson's Disease [PDF]

, 2018
Several neurotrophic factors ( NTF) are shown to be neuroprotective and neurorestorative in pre-clinical animal models for Parkinson's disease ( PD), particularly in models where striatal dopamine neuron innervation partially exists.
Airavaara, Mikko, Bäck, Susanne, Huotarinen, Antti, Julku, Ulrika, Laakso, Aki, Männistö, Pekka T., Penttinen, Anna-Maija, Piepponen, T. Petteri, Saarma, Mart, Tuominen, Raimo, Voutilainen, Merja H.   +10 more
core   +1 more source

Stability of apomorphine in solutions containing selected antioxidant agents

Drug Design, Development and Therapy, 2016
Zen Yang Ang, Michael Boddy, Yandi Liu, Bruce Sunderland School of Pharmacy, Faculty of Health Sciences, Curtin University, Bentley, WA, Australia Abstract: Apomorphine in solution undergoes rapid autoxidation, producing greenish colored solutions ...
Ang ZY, Boddy M, Liu Y, Sunderland B
doaj  

The Pharmacological Properties and Therapeutic Use of Apomorphine

Molecules, 2012
Apomorphine <strong>(</strong>APO) is an aporphine derivative used in human and veterinary medicine. APO activates D₁, D_2S, D_2L, D₃, D<sub>4</
Samo Ribarič
doaj   +1 more source

Apomorphine-induced disruption of prepulse inhibition that can be normalised by systemic haloperidol is insensitive to clozapine pretreatment [PDF]

, 2018
Rationale: Prepulse inhibition (PPI) of startle refers to the phenomenon in which a weak prepulse attenuates the startle response to a succeeding intense stimulus.
Durkin, S., Feldon, J., Russig, H., Spooren, W., Yee, B.   +4 more
core  

Control of serotonergic neurons in rat brain by dopaminergic receptors outside the dorsal raphe nucleus [PDF]

, 2001
We studied the control of dorsal raphe (DR) serotonergic neurons by dopaminergic transmission in rat brain using microdialysis and single unit extracellular recordings. Apomorphine (0.5–3.0 mg/kg s.c.) and quinpirole (0.5 mg/kg s.c.) increased serotonin (
Artigas, Francesc, Honrubia, María Ángeles, Martín-Ruiz, Raúl, Mengod Los Arcos, Guadalupe, Ugedo, Luisa   +4 more
core   +1 more source

Transfer of paracetamol across the placenta and fetal blood–brain barriers and its safety for use in pregnancy

The Journal of Physiology, EarlyView.
Abstract figure legend Paracetamol (acetaminophen) is commonly taken during pregnancy for pain and fever. To gain a more comprehensive understanding of paracetamol's effects during pregnancy, several elements need to be examined including the transfer of paracetamol across the placenta and into the developing brain, the short‐ and long‐term effects of ...
Yifan Huang, Liam Koehn
wiley   +1 more source

Maternal nutrition as a key determinant of placental and developing blood–brain barrier xenobiotic protective functions

The Journal of Physiology, EarlyView.
Abstract figure legend Suboptimal maternal nutrition alters placental and developing blood–brain barrier (BBB) protective function and is associated with increased fetal brain vulnerability. In the placenta, nutritional adversity may reduce the exchange surface area and promote meta‐inflammation, compromising barrier efficiency in a model‐ and context ...
Kristin L. Connor, Nycolle I. S. Souza, Bruno G. Anjos, Stephen G. Matthews, Enrrico Bloise   +4 more
wiley   +1 more source

Asenapine effects in animal models of psychosis and cognitive function [PDF]

, 2009
Asenapine, a novel psychopharmacologic agent in the development for schizophrenia and bipolar disorder, has high affinity for serotonergic, α-adrenergic, and dopaminergic receptors, suggesting potential for antipsychotic and cognitive-enhancing ...
Hugh M. Marston, Jared W. Young, Frederic D. C. Martin, Kevin A. Serpa, Christopher L. Moore, Erik H. F. Wong, Lisa Gold, Leonard T. Meltzer, Marc R. Azar, Mark A. Geyer, Mohammed Shahid, Z Abdul-Monim, Z Abdul-Monim, J Addington, N Amitai, N Amitai, J Arnt, J Arnt, AL Auclair, JM Birrell, MJ Cuesta, M Didriksen, M Didriksen, DJ Feldman, O Franberg, MA Geyer, MA Geyer, B Grayson, JJ Hagan, PD Hatcher, WD Hirst, M Huang, NF Idris, Institute of Laboratory Animal Resources, JD Jentsch, S Kapur, ED Levin, JA Lieberman, RS Mansbach, MM Marcus, R McIntyre, DD Miller, S Nakai, JC Neill, JC Neill, RE Nordquist, SG Potkin, D Quarta, G Remington, H Rosengarten, A Schotte, M Shahid, T Sharma, AD Smith, IA Sukhotina, NR Swerdlow, DS Tait, FI Tarazi, JP Terranova, AV Terry Jr, GB Varty, GB Varty, CP Ward, MC Wolff   +63 more
core   +2 more sources

Tracking Motor Progression and Device‐Aided Therapy Eligibility in Parkinson's Disease

Annals of Clinical and Translational Neurology, Volume 13, Issue 5, Page 958-971, May 2026.
ABSTRACT Objective To characterise the progression of motor symptoms and identify eligibility for device‐aided therapies in Parkinson's disease, using both the 5‐2‐1 criteria and a refined clinical definition, while examining differences across genetic subgroups.
David Ledingham, Sahana Sathyanarayana, Charlotte B. Stewart, Robyn Iredale, Victoria Foster, Debra Galley, Mark Baker, Nicola Pavese   +7 more
wiley   +1 more source