Results 81 to 90 of about 13,147 (207)
Evaluation of Antipsychotic Activity of Ethanolic Bark Extract of Myrica esculenta in Rats
Pharmaceutical Sciences and Research, 2020 The antipsychotic properties of Myrica esculenta stem bark were evaluated. The stem bark was collected, shade dried, and pulverized. Extraction was carried out with 70% ethanol by occasional shaking. Preliminary phytochemical screening of the extract was
Biswash Sapkota +3 more
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Apomorphine in Parkinson’s disease 4th edition [PDF]
, 2020 Apomorphine is one of the oldest and, at the same time, most potent drugs for the treatment of Parkinson s disease. Its use was for decades inhibited by the occurrence of dopaminergic side effects and the lack of practical equipment for its delivery. But
Odin, Per, +3 more
core
Movement Disorders, Volume 41, Issue 7, Page 1750-1761, July 2026.Abstract Background Leucine‐rich repeat kinase 2 (LRRK2) kinase inhibition is a promising therapeutic strategy for Parkinson's disease (PD), but the functional impact of Asian‐prevalent LRRK2 p.G2385R and p.R1628P variants remains unclear. Robust patient stratification and target engagement markers are needed for global LRRK2‐targeted trials ...
Tzi Shin Toh +17 more
wiley +1 more source
The Pharmacological Properties and Therapeutic Use of Apomorphine
Molecules, 2012 Apomorphine <strong>(</strong>APO) is an aporphine derivative used in human and veterinary medicine. APO activates D<sub>1</sub>, D<sub>2S</sub>, D<sub>2L</sub>, D<sub>3</sub>, D<sub>4</
Samo Ribarič
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Veterinary Medicine and Science, Volume 12, Issue 4, July 2026.This review evaluates the clinical potential and limitations of intranasal (IN) drug administration in veterinary anaesthesia and emergency care. IN delivery can provide clinically relevant sedation, analgesia and drug reversal, but its success is not universally reliable and is strongly influenced by species‐specific anatomy, formulation ...
Majid Jafarbeglou
wiley +1 more source
Sleep induced by low doses of apomorphine in rats. [PDF]
, 1979 The effect of apomorphine on the EEG of freely moving rats was studied. Apomorphine at the dose of 1 mg/kg caused stereotypy and a marked reduction of total sleep.
Mereu G. P +6 more
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Freezing of Gait Levodopa Response Pattern in Parkinson's Disease Provides Clues to Pathophysiology
European Journal of Neuroscience, Volume 64, Issue 1, July 2026.ABSTRACT Freezing of gait (FOG) is a common and enigmatic feature of Parkinson's disease (PD) because of its episodic and unpredictable nature. It is now clear that FOG is not a monolithic phenomenon but instead exhibits substantial heterogeneity across patients, suggesting the existence of subtypes.
Stewart A. Factor +5 more
wiley +1 more source
The efficacy of apomorphine – A non-motor perspective [PDF]
, 2016 Non-motor features have a great impact on progression and quality of life in individuals with Parkinson's disease. Current treatments for PD are limited and apomorphine is one of the advanced therapies available with advantageous effects on motor ...
Qamar, Mubasher A. +3 more
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European Journal of Neurology, Volume 33, Issue 7, July 2026.In 214 patients with advanced Parkinson's disease receiving foslevodopa/foscarbidopa continuous subcutaneous infusion, neuropsychiatric adverse events occurred in 19.2%. Baseline cognitive impairment and hallucinations did not increase risk, whereas preexisting impulse control disorders predicted ICD‐related adverse events.
David Campo‐Caballero +130 more
wiley +1 more source
Synthetic aporphine alkaloids are potential therapeutics for Leigh syndrome
Scientific ReportsMitochondrial diseases are mainly caused by dysfunction of mitochondrial respiratory chain complexes and have a variety of genetic variants or phenotypes. There are only a few approved treatments, and fundamental therapies are yet to be developed.
Mizuki Kobayashi +9 more
doaj +1 more source