Results 101 to 110 of about 13,147 (207)

Apomorphine therapy in Parkinson's disease: a review [PDF]

, 2007
Motor fluctuations are common and distressing for patients with advanced Parkinson's disease. Subcutaneous apomorphine injections can be an extremely valuable adjunctive therapy.
Lewitt, Peter A, Fernandez, Hubert H, Haq, Ihtsham, Ul Haq, Ihtsham   +3 more
core   +1 more source

Gender disparity in access to advanced therapies for patients with Parkinson’s disease: a retrospective real-word study

Frontiers in Neurology
BackgroundGender differences in the access to advanced therapies for Parkinson’s disease (PD) are poorly investigated.ObjectiveThe objective of this study was to investigate the presence of any gender disparity in the access to advanced therapies for PD ...
Giuseppe Maccarrone, Gennaro Saporito, Patrizia Sucapane, Chiara Rizi, Federico Bruno, Alessia Catalucci, Maria Letizia Pistoia, Alessandra Splendiani, Alessandro Ricci, Ernesto Di Cesare, Marina Rizzo, Rocco Totaro, Francesca Pistoia, Francesca Pistoia   +13 more
doaj   +1 more source

Responses to apomorphine of pigs with different coping characteristics [PDF]

, 2000
Rationale: Classification of pigs based on the degree of resistance they display in a so-called "backtest" seems, to a certain extent, predictive for their coping strategy.
Schouten, W.G.P., Jong, I.C. de, Cools, A.R., Schrama, J.W., Wiegant, V.M., Bolhuis, J.E., de Jong, I.C., Jong, I.C., de   +7 more
core   +1 more source

Distribution of apomorphine enantiomers in plasma, brain tissue and striatal extracellular fluid [PDF]

, 1997
Steady-state concentrations of apomorphine enantiomers were measured in the extracellular fluid collected from rat brain striatum by microdialysis. The free and total concentrations of both enantiomers were also measured in plasma as well as the total ...
Sarre, S., Sam, E., Verbeke, Norbert, Yvette Michotte, Michotte, Y., Sophie Sarre, Norbert Verbeke, Exaud Sam   +7 more
core   +1 more source

Apomorphine for prolonged disorders of consciousness: a multimodal open-label studyResearch in context

EClinicalMedicine
Summary: Background: Apomorphine is a dopaminergic candidate therapy to improve recovery in patients with prolonged disorders of consciousness (PDoC). Behavioural improvements were previously described in non-controlled case series, but its efficacy and
Leandro R.D. Sanz, Nicolas Lejeune, Emilie Szymkowicz, Estelle A.C. Bonin, Rajanikant Panda, Arianna Sala, Aurore Thibaut, Rodrigo Huerta-Gutierrez, Nadia Dardenne, David Dikenstein, Sébastien Van Goethem, Didier Ledoux, Roland Hustinx, Johan Stender, Neal M. Farber, Ross D. Zafonte, Nicholas D. Schiff, Steven Laureys, Olivia Gosseries   +18 more
doaj   +1 more source

Regional neurochemical profile following co-administration of apomorphine and buspirone in an animal model of addiction

Pakistan Journal of Pharmaceutical Sciences
Although dopamine is the primary neurotransmitter mediating the reinforcing outcomes of abused drugs, serotonin (5-hydroxytryptamine; 5HT) also performs an important function in addiction pathophysiology.
Huma Ikram, Darakhshan Jabeen Haleem
doaj   +1 more source

Effects of chronic mild stress on apomorphine induced behavioral sensitization in different brain regions of rats in relation to serotonin change

Advancements in Life Sciences, 2015
Background: The impacts of unpredictable stressors have influence on neurochemical and behavioral parameters in laboratory animals. Stress induced behavioral changes particularly those associated with anxiety like behavior may activate topographically ...
Muhammad Farhan, Darakshan Jabeen Haleem
doaj  

Therapeutical and experimental usefulness of apomorphine [PDF]

, 1981
Apomorphine induces behavioural changes in man in some way similar to those elicited by low doses of the drug in animals. In fact, in man a complex symptomatology, in which sedation and psycho-motor reduction predominates, is elicited by non-emetic doses
GESSA GL, DEL ZOMPO, MARIA, RACHELE MG, PICCARDI MP, CORSINI GU   +4 more
core  

Non-Targeted Metabolomics Reveal Apomorphine’s Therapeutic Effects and Lysophospholipid Alterations in Steatohepatitis

Antioxidants
Metabolic dysfunction-associated steatohepatitis (MASH), characterized by progressive inflammation and fibrosis, evolves from metabolic dysfunction-associated steatotic liver disease and significantly heightens the risk of cirrhosis and hepatocellular ...
Hideo Ogiso, Kouichi Miura, Ryozo Nagai, Hitoshi Osaka, Kenichi Aizawa   +4 more
doaj   +1 more source

Effects of Continuous Infusion Therapies on Non-Motor Symptoms in Advanced Parkinson’s Disease: A Systematic Review

Brain Sciences
Background/Objectives: Non-motor symptoms (NMS) are highly prevalent in advanced Parkinson’s disease (PD) and substantially affect quality of life. Continuous infusion therapies are established treatment options for motor fluctuations not controlled by ...
Domiziana Rinaldi, Lanfranco De Carolis, Claudia Ledda, Silvia Galli, Morena Giovannelli, Alberto Romagnolo, Maurizio Zibetti, Marco Salvetti, Leonardo Lopiano, Gabriele Imbalzano   +9 more
doaj   +1 more source