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Contains fulltext : 50736.pdf (Publisher’s version ) (Closed access)Dopaminergic agonists, such as apomorphine and amphetamine, have been shown to drastically reduce prepulse inhibition of the acoustic startle reflex. The effects of the
Elst, M.C.J. van der +2 more
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The locomotion and stereotyped behaviours induced by the two dopamine agonists, 1-amino-3,5-dimethyladamantane (D 145) and apomorphine in rats have been investigated using a holeboard apparatus. Unlike apomorphine, D 145 did not induce compulsive gnawing,
Thomas Ljungberg
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Apomorphine-induced penile erections in Parkinson's disease
Penile erections were regularly induced by intermittent subcutaneous injections of apomorphine in five patients with Parkinson's disease (PD) complicated by motor fluctuations.
O'Sullivan, JD, Hughes, AJ
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Effects of repeated apomorphine and haloperidol treatments on subsequent behavioral sensitivity to apomorphine. PHARMACOL BIOCHEM BEHAV 34(2) 345-347, 1989.- In a 2 × 2 factorial design, four groups of rats (n = l0 each) were injected daily with ...
Rowlett, James K., Mattingly, Bruce A.
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Sensitization to and conditioning with apomorphine in pigeons
Pigeons that repeatedly experienced the effect of apomorphine in the same environment showed an augmented behavioural response to the same drug dose as compared with controls that experienced the effect of the drug dose in differing environments ...
Delius, Juan +3 more
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Metabolic dysfunction-associated steatohepatitis (MASH), characterized by progressive inflammation and fibrosis, evolves from metabolic dysfunction-associated steatotic liver disease and significantly heightens the risk of cirrhosis and hepatocellular ...
Hideo Ogiso +4 more
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Background/Objectives: Non-motor symptoms (NMS) are highly prevalent in advanced Parkinson’s disease (PD) and substantially affect quality of life. Continuous infusion therapies are established treatment options for motor fluctuations not controlled by ...
Domiziana Rinaldi +9 more
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Behavioural and neurochemical studies on apomorphine-induced hypomotility in mice
Small doses of apomorphine (0.075–0.60 μmol/kg), injected subcutaneously into mice, elicited a strong hypomotive response of 20 to 30 min duration. This effect could be inhibited not only by neuroleptics, such as pimozide or sulpiride, but was also ...
Sumners, C. +2 more
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Enhancement of transdermal apomorphine delivery with a diester prodrug strategy
Diester prodrugs of apomorphine, diacetyl apomorphine (DAA), and diisobutyryl apomorphine (DIA), were synthesized, and their partition coefficients, capacity factor (log K'), enzymatic hydrolysis, and in vitro permeation across nude mouse skin were ...
Ming-Chuan Ku +2 more
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Apomorphine-induced behavioural sensitization was studied in male Wistar rats. The acute administration of apomorphine (0.5 mg/kg s.c.), a dopamine agonist, did not affect the locomotor activity of rats, but it caused stereotyped behaviour characterized ...
Volke, V. +6 more
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