Results 91 to 100 of about 554,589 (315)
Clinical Pharmacology &Therapeutics, EarlyView.Adverse drug reactions (ADRs) are a common cause of morbidity and mortality in hospitalized patients. Identification of ADRs in clinical practice, surveillance and research is essential to prevent further harm. The aim of this study was to assess the likelihood of drugs contributing to clinically important inpatient adverse events, in order to provide ...
Anna Maria Wermund +5 more
wiley +1 more source
Molecular Communication-Based Intelligent Dopamine Rate Modulator for Parkinson's Disease Treatment [PDF]
Parkinson's disease (PD) is a progressive neurodegenerative disease, and it is caused by the loss of dopaminergic neurons in the basal ganglia (BG). Currently, there is no definite cure for PD, and available treatments mainly aim to alleviate its symptoms.
arxiv +1 more source
TRPC4 ion channel protein is selectively expressed in a subpopulation of dopamine neurons in the ventral tegmental area [PDF]
, 2012 The nonselective cation channel TRPC4 has been shown to be present in high abundance in the corticolimbic regions of the brain and play a pivotal role in modulating cellular excitability due to their involvement in intracellular Ca2+ regulation. Recently we reported their involvement in socialization and regulating anxiety-like behaviors in rats. Given
arxiv +1 more source
Effects of a dopamine agonist on the pharmacodynamics of levodopa in Parkinson disease.
Archives of Neurology, 2010 BACKGROUND Treatment of Parkinson disease commonly includes levodopa and dopamine agonists; however, the interaction of these 2 drugs is poorly understood.
M. Brodsky, B. S. Park, J. Nutt
semanticscholar +1 more source
Drug Testing and Analysis, EarlyView.The novel lysergamide 1‐(furan‐2‐carbonyl)‐LSD (1F‐LSD) was analytically characterized. 1F‐LSD showed LSD‐like activity in vivo similar to 1‐(thiophene‐2‐carbonyl)‐LSD (1T‐LSD) used for comparison. Administration studies in mice and LC–MS analysis revealed that 1F‐LSD served as a prodrug.
Simon D. Brandt +5 more
wiley +1 more source
High level modeling of tonic dopamine mechanisms in striatal neurons [PDF]
arXiv, 2007 The extant versions of many basal ganglia models use a `gating' model of dopamine function which enhances input to D1 receptor units and attenuates input to D2 receptor units. There is evidence that this model is unsatisfactory because (a) there are not sufficient dopaminergic synapses to gate all input and (b) dopamine's main effect is likely to be on
arxiv
Drug Testing and Analysis, EarlyView.Scenarios of drug exposure and administration as well as detection assays for drugs and methods of sports doping published between 2023 and 2024 are critically reviewed and evaluated in context with the Prohibited List 2024 as established by the World Anti‐Doping Agency.
Mario Thevis +2 more
wiley +1 more source
Mothers, milk and mourning: The meanings of breast milk after loss of an infant
Sociology of Health &Illness, Volume 45, Issue 1, Page 109-127, January 2023., 2023 Abstract Breast milk is a highly valued substance, immunologically and nutritionally, which also signifies maternal care and love for the infant. This intersection of biological and cultural qualities confers breast milk with complex meanings, which necessarily shape the experience of breastfeeding.
Catherine Waldby +2 more
wiley +1 more source
Synthetic aporphine alkaloids are potential therapeutics for Leigh syndrome
Scientific ReportsMitochondrial diseases are mainly caused by dysfunction of mitochondrial respiratory chain complexes and have a variety of genetic variants or phenotypes. There are only a few approved treatments, and fundamental therapies are yet to be developed.
Mizuki Kobayashi +9 more
doaj +1 more source
Untreated Giant Macroprolactinoma with Chronic Cerebrospinal Fluid Leakage: An Unusual Complication
Case Reports in Endocrinology, 2019 Macroprolactinoma has the potential to cause base of skull erosion and often extends into the sphenoid sinus. Rapid shrinkage of this invasive tumor following dopamine agonist therapy has been postulated to cause unplugging of the eroded area, leading to
Mohamad Nazrulhisham Mad Naser +2 more
doaj +1 more source