Results 281 to 290 of about 554,589 (315)

Fatty‐acid amide hydrolase inhibition mitigates Alzheimer's disease progression in mouse models of amyloidosis

The FEBS Journal, EarlyView.
Enhancing endocannabinoid signaling by targeting FAAH effectively mitigates cognitive deficits, reduces amyloid pathology, and modulates neuroinflammatory responses in a preclinical model of Alzheimer's disease. This effect is potentially mediated by attenuating the Aβ‐induced overexpression of the Bace1 gene through CB1‐dependent hypermethylation of ...
Sergio Oddi, Lucia Scipioni, Antonio Totaro, Giacomo Giacovazzo, Francesca Ciaramellano, Daniel Tortolani, Alessandro Leuti, Rita Businaro, Federica Armeli, Andras Bilkei‐Gorzo, Roberto Coccurello, Andreas Zimmer, Mauro Maccarrone   +12 more
wiley   +1 more source

Dopamine agonist-responsive Cushing's disease. [PDF]

BMJ Case Rep, 2019
Anand G, Bink A, Beuschlein F, Schmid C.
europepmc   +1 more source

A signal transduction blind spot: the function of adenylyl cyclase transmembrane domains

The FEBS Journal, EarlyView.
Transmembrane adenylyl cyclases (tmACs) are essential for synthesising the universal second messenger cyclic AMP. All tmACs share a common topology that includes a large 12‐helix transmembrane (TM) domain. This domain accounts for ~ 35% of the coding sequence but its function is still an open question.
Ryan S. Dowsell, Matthew G. Gold
wiley   +1 more source

“Don't Work for Soyciety:” Involuntary Celibacy and Unemployment

Gender, Work &Organization, EarlyView.
ABSTRACT Surveys of involuntary celibates (“incels”) suggest that they tend to be not in education, employment or training (NEET) at disproportionately high rates. However, it remains unclear whether and how being NEET is connected to incels' ideology and life circumstances.
AnnaRose Beckett‐Herbert, Eran Shor
wiley   +1 more source

Nurse Practitioner Conceptions of Capability Providing Medication and Safe Supply for Opioid Use Disorder in Primary Care: A Phenomenographic Study

Journal of Advanced Nursing, EarlyView.
ABSTRACT Aims To explore how nurse practitioners experienced and understood development of their capability providing medication for opioid use disorder and safe supply in North American primary care settings. Design A phenomenographic approach was applied to the study design, recruitment, and analysis. Methods Semi‐structured interviews were conducted
Martha M. Whitfield, Mike Mimirinis, Danielle Macdonald, Tracy Klein, Rosemary Wilson   +4 more
wiley   +1 more source

Conclusion lessons from the novel D2 dopamine receptor, β2-adrenoceptor agonist, Viozan™: chronic obstructive pulmonary disease and drug development implications

, 2003
P. M. A. Calverley, E.T. Keating, Mitch Goldman, Frank E. Casty   +3 more
openalex   +1 more source

Early clinical investigation of Viozan™ (sibenadet HCI), a novel D2 dopamine receptor, β2-adrenoceptor agonist for the treatment of chronic obstructive pulmonary disease symptoms

, 2003
P.W. Ind, L. A. Laitinen, L S Laursen, Sally E. Wenzel, E.F.M. Wouters, L. Deamer, P O Nyström   +6 more
openalex   +1 more source

Bifidobacterium Lactobacillus Triple Viable Alleviates Slow Transit Constipation by Regulating Gut Microbiota and Metabolism

Journal of Gastroenterology and Hepatology, EarlyView.
ABSTRACT Background Gut microbiota plays a crucial role in the pathogenesis and treatment of functional constipation (FC). The aim of this study was to explore the therapeutic effects of Bifidobacterium Lactobacillus triple viable on slow transit constipation (STC).
Mei Luo, Peiwei Xie, Xuehong Deng, Jiahui Fan, Lishou Xiong   +4 more
wiley   +1 more source

Conclusion lessons from the novel D2 dopamine receptor, $beta;2-adrenoceptor agonist, Viozan?: chronic obstructive pulmonary disease and drug development implications

, 2003
P CALVERLEY
openalex   +1 more source

Neuroactive steroid exposure impacts neurodevelopment: Comparison of human and rodent placental contribution

Journal of Neuroendocrinology, EarlyView.
Abstract The placenta is a fetal endocrine organ that secretes many neuroactive factors, including steroids, that play critical roles in brain development. The study of the placenta‐brain axis and the links between placental function and brain development represents an emerging research area dubbed “neuroplacentology.” The placenta drives many ...
Claire‐Marie Vacher, Alex Tsompanidis, Morgan R. Firestein, Anna A. Penn   +3 more
wiley   +1 more source