Results 41 to 50 of about 315,867 (288)

Microenvironmental Reprogramming by 3D Anisotropic Cardiac Extracellular Matrix Induces Nuclear Remodeling and Epigenetic Maturation of Chemically Induced Cardiomyocytes

Advanced Functional Materials, EarlyView.
A 3D anisotropic hydrogel derived from heart extracellular matrix guides cytoskeletal alignment and nuclear remodeling in reprogrammed cardiomyocyte‐like cells. This study reveals how matrix alignment modulates nuclear envelope dynamics and chromatin state, triggering transcriptional and functional maturation.
Seung Ju Seo, Mi Jeong Lee, Hyun Wook Kang, Seonhee Byeon, Soo‐Kyoung Choi, Nakwon Choi, Seung‐Woo Cho, Yoonhee Jin   +7 more
wiley   +1 more source

Pharmacological Evidence That Dopamine Inhibits the Cardioaccelerator Sympathetic Outflow via D2-Like Receptors in Pithed Rats

Journal of Pharmacological Sciences, 2013
It has been suggested that N,N-di-n-propyl-dopamine (dopamine analogue) decreased heart rate in rats through stimulation of dopamine receptors. Nevertheless, the role of prejunctional dopamine D1/2-like receptors or even α2-adrenoceptors to mediate ...
Oscar Alcántara-Vázquez, Ma. Trinidad Villamil-Hernández, Araceli Sánchez-López, David Centurión   +3 more
doaj   +1 more source

Resistance to Dopamine Agonists in Pituitary Tumors: Molecular Mechanisms

Frontiers in Endocrinology, 2022
Pituitary neuroendocrine tumors (PitNET) are commonly benign tumors accounting for 10-25% of intracranial tumors. Prolactin-secreting adenomas represent the most predominant type of all PitNET and for this subtype of tumors, the medical therapy relies on
Claudia Pivonello, Roberta Patalano, Roberta Patalano, Mariarosaria Negri, Rosa Pirchio, Annamaria Colao, Annamaria Colao, Rosario Pivonello, Rosario Pivonello, Renata Simona Auriemma   +9 more
doaj   +1 more source

Development of novel ligands influencing neurotransmission in the central nervous system [PDF]

, 2007
The development of novel drugs targeting GPCRs is of particular interest since modulation of subfamilies of this receptor class highly influences neurotransmission in the central nervous system.
Sasse, Britta Caroline
core  

Mitochondria‐Targeted Nanotherapies in Aging Neurodegenerative Disorders: Emerging Prospects and Clinical Potential

Advanced Healthcare Materials, EarlyView.
Mitochondria‐targeted nanotherapies emerge as a promising strategy for combating aging‐associated neurodegenerative disorders (NDs) by restoring mitochondrial function, reducing oxidative stress, and improving neuronal survival. Recent advances in nanotechnology, therapeutic delivery, and translational research are highlighted, providing insights into ...
Dnyandev G. Gadhave, Ashish B. Jadhav, Nitin B. Waghamode, Shubham Khot, Rajiya Khan, Ravi Hole, Shankar M. Dhobale, Manoj Aswar, Keshav Raj Paudel   +8 more
wiley   +1 more source

DOPAMINE AND THE BIOLOGY OF CREATIVITY: LESSONS FROM PARKINSON’S DISEASE

Frontiers in Neurology, 2014
BACKGROUND: Parkinson’s disease (PD) is characterized by reduced flexibility, conceptualization and visuo-spatial abilities. Although these are essential to creativity, case studies show emergence of creativity during PD.
Eugénie eLhommée, Eugénie eLhommée, Alina eBatir, Jean-Louis eQuesada, Claire eArdouin, Valérie eFraix, Valérie eFraix, Eric eSeigneuret, Stéphan eChabardès, Stéphan eChabardès, Alim-Louis eBenabid, Pierre ePollak, Paul eKrack, Paul eKrack   +13 more
doaj   +1 more source

Voltage-Dependent Dopamine Potency at D1-Like Dopamine Receptors

Frontiers in Pharmacology, 2020
In recent years, transmembrane voltage has been found to modify agonist potencies at several G protein-coupled receptors (GPCRs). Whereas the voltage sensitivities of the Gαi/o-coupled dopamine D2-like receptors (D2R, D3R, D4R) have previously been ...
Richard Ågren, Kristoffer Sahlholm, Kristoffer Sahlholm, Kristoffer Sahlholm   +3 more
doaj   +1 more source

In vivo imaging of dopamine and serotonin release: response to psychopharmacological challenges [PDF]

, 2005
De neurotransmitters dopamine en serotonine zijn betrokken bij vele processen waaronder de regulatie van beloningsmechanismen (dopamine) en de stemming (serotonine).
Udo de Haes, Joanna Irene,, Udo de Haes, Joanna Irene   +1 more
core   +12 more sources

Motor activity following the administration of selective D-1 and D-2 dopaminergic drugs to MPTP-treated common marmosets [PDF]

, 1992
The ability of selective D-1 agonist and antagonist drugs to alter motor deficits and locomotor activity was studied in MPTP-treated common marmosets.
Smith, L. A., Jähnig, P., Marsden, C. D., Jenner, P., Lange, Klaus W., Löschmann, P. A.   +5 more
core   +1 more source

Remote Magnetomechanical Neuromodulation Uncovers Therapeutic Mechanisms for Alleviating Parkinsonian Symptoms in Freely Moving Mice

Advanced Science, EarlyView.
Magnetomechanical neuromodulation using magnetic nanodiscs enables remote activation of neurons. In a hemiparkinsonian mouse model, alternating magnetic fields actuate the nanodiscs to generate torque that opens mechanosensitive ion channels within the subthalamic nucleus, thereby modulating basal ganglia motor circuitry.
Anouk Wolters, Lorenzo Signorelli, Christian Herff, Sophia Gimple, Renzo Riemens, Gunter Kenis, Kim Rijkers, Hamed Shabani, Jyh‐Jang Sun, Yasin Temel, Hans Clusmann, Danijela Gregurec, Sarah‐Anna Hescham   +12 more
wiley   +1 more source