Results 221 to 230 of about 58,665 (272)
The FASEB Journal, Volume 40, Issue 5, 15 March 2026.In SH‐SY5Y cells, Methylglyoxal (MGO) reduces the intracellular dopamine content, up‐regulating the expression of proteins that modulate dopamine amount (MAO‐B, COMT, and α‐Syn). The MGO‐induced increase of COMT and α‐Syn expression is mediated by the reduction of miR‐214 and miR‐190a levels.
Alessandra Croce +9 more
wiley +1 more source
Asymmetric Negishi and Kumada Couplings
Advanced Synthesis &Catalysis, Volume 368, Issue 5, 3 March 2026.This review summarizes asymmetric Negishi and Kumada cross‐coupling reactions from the 1980s through 2025. It examines enantioselective and enantiospecific transformations catalyzed by nickel, palladium, and cobalt complexes , highlighting ligand design, mechanistic insights, and applications in constructing complex chiral molecules and natural ...
Rui‐Heng Wang, Aishun Ding, Ramon Rios
wiley +1 more source
The Pivotal Distinction between Antagonists’ and Agonists’ Binding into Dopamine D4 Receptor—MD and FMO/PIEDA Studies [PDF]
Paweł Śliwa +3 more
openalex +1 more source
Accelerated Progression of Gait Impairment in Parkinson's Disease and REM Sleep Without Atonia
Annals of Clinical and Translational Neurology, Volume 13, Issue 3, Page 517-529, March 2026.ABSTRACT Objective People with Parkinson's disease (PD) and rapid eye movement (REM) sleep without atonia (RSWA) often have more severe gait disturbances compared to PD without RSWA. The association between the presence and expression of RSWA and the rate of progression of gait impairment in PD is unknown.
Sommer L. Amundsen‐Huffmaster +11 more
wiley +1 more source
Navigating the Ethereal Tightrope: The Nanogenerator Manipulates Neurons for Immune Equilibrium
Advanced Science, Volume 13, Issue 14, 9 March 2026.This review explores how nanogenerators modulate neuroimmune responses, offering innovative strategies for treating neurological disorders. By interfacing with neural pathways, they enable precise control of immune activity, especially via vagus nerve stimulation.
Jia Du +5 more
wiley +1 more source
The neuromodulatory fragility hypothesis of Alzheimer's disease pathogenesis
Alzheimer's &Dementia, Volume 22, Issue 3, March 2026.Abstract Sporadic Alzheimer's disease (AD) is associated with numerous risk factors, yet its precise cause remains unclear. Here, we describe a novel framework for AD pathogenesis, whereby diverse risk factors converge on neuromodulatory subcortical systems to confer AD risk or resilience.
Alfie Wearn +4 more
wiley +1 more source
Brain and Behavior, Volume 16, Issue 3, March 2026.The results of this study demonstrated that olanzapine can inhibit morphine‐induced CPP behavior during the acquisition, expression, and extinction phases. These effects are likely mediated by the inhibition of dopamine receptors and a reduction in D2R protein expression in the HIP.
Farkhondeh Rzazzaghi‐ Firozjaei +6 more
wiley +1 more source
MXene‐Based Functional Platforms for Diabetes Prevention and Treatment
Carbon Neutralization, Volume 5, Issue 2, March 2026.MXenes have been applied to antidiabetic treatment (wound treatment, glucose monitoring, and treatment of complications) with the representative work. ABSTRACT In recent years, a class of 2D transition metal carbides, nitrides, and carbonitrides (MXenes) has demonstrated outstanding advantages in the field of diabetes treatment, particularly in ...
Zixuan Wang +5 more
wiley +1 more source
Food Frontiers, Volume 7, Issue 2, March 2026.Hyperuricaemia is a chronic metabolic disorder arising from impaired purine metabolism, exhibiting marked gender disparities in its prevalence. Daidzein, possessing oestrogen‐like effects, promotes uric acid excretion and improves hepatic and renal function, thereby presenting potential utility as an adjunctive therapeutic agent for hyperuricaemia ...
Zicheng Zhu +9 more
wiley +1 more source