Results 241 to 250 of about 589,499 (392)

Dopamine-Deficient Mice Are Hypersensitive to Dopamine Receptor Agonists [PDF]

, 2000
Douglas S. Kim, Mark S. Szczypka, Richard D. Palmiter   +2 more
openalex   +1 more source

Genetic and Pharmacological Inhibition of Metabotropic Glutamate Receptor Signalling Extends Lifespan in Drosophila

Aging Cell, EarlyView.
We show that genetic and pharmacological inhibition of the metabotropic glutamate receptor, DmGluRA extends Drosophila lifespan, improves stress tolerance and alters early‐life locomotion. Several markers indicative of reduced ribosomal biogenesis, a hallmark of longevity, were also detected in these flies.
Cui Guan, Abigail Otchere, Mihails Laskovs, Irene Papatheodorou, Cathy Slack   +4 more
wiley   +1 more source

Macroprolactinoma Shrinkage during Cabergoline Treatment Is Greater in Naive Patients Than in Patients Pretreated with Other Dopamine Agonists: A Prospective Study in 110 Patients1 [PDF]

, 2000
Annamaria Colao, Antonella Di Sarno, Maria Luisa Landi, Francesco Scavuzzo, Paolo Cappabianca, Rosario Pivonello, Raffaele Volpe, Francesco Di Salle, S. Cirillo, Lucio Annunziato, Gaetano Lombardi   +10 more
openalex   +1 more source

Enhanced Microglial Engulfment of Dopaminergic Synapses Induces Parkinson's Disease‐Related Executive Dysfunction in an Acute LPC Infusion Targeting the mPFC

Aging Cell, EarlyView.
Parkinson's disease with executive dysfunction is a challenge. Our study reveals a novel pathway where abnormally elevated LPC induces miR‐2885/TDP‐43 signal activation in microglia, leading to dopaminergic terminal phagocytosis, and suggests that supplementing dopamine or inhibiting related microglial activation can mitigate the dysfunction, providing
Yehao Liu, Rui Chen, Chunyan Mu, Junjie Diao, Yurong Guo, Xiaoyu Yao, Shijie Shi, Mengying Wang, Zhi Zhang, Xiaoling Qin, Chuanxi Tang   +10 more
wiley   +1 more source

Increased prevalence of impulse control disorder symptoms in endocrine diseases treated with dopamine agonists: a cross-sectional study. [PDF]

J Endocrinol Invest, 2021
Beccuti G, Guaraldi F, Natta G, Cambria V, Prencipe N, Cicolin A, Montanaro E, Lopiano L, Ghigo E, Zibetti M, Grottoli S.   +10 more
europepmc   +1 more source

Fenoldopam, a Dopamine Agonist, for Hypertensive Emergency: A Multicenter Randomized Trial [PDF]

, 2000
James A. Tumlin, Lala M. Dunbar, Suzanne Oparil, Vardaman M. Buckalew, C. Venkata S. Ram, Vandana Mathur, David Ellis, Dawn McGuire, J. D. FELLMANN, Robert R. Luther   +9 more
openalex   +1 more source

Blood phosphatidylethanol measurements indicate GLP‐1 receptor stimulation causes delayed decreases in alcohol consumption

Alcohol, Clinical and Experimental Research, EarlyView.
Glucagon‐like peptide 1 receptor agonists (GLP‐1RAs) are effective for treating obesity (BMI ≥30) and are being investigated as a novel treatment for alcohol use disorder (AUD). This secondary analysis of a randomized clinical trial evaluated the effect of exenatide versus placebo on alcohol consumption using phosphatidylethanol (PEth) in 30 AUD ...
Mathias E. Jensen, Mette K. Klausen, Marianne L. Bergmann, Gitte M. Knudsen, Tina Vilsbøll, Christophe Stove, Anders Fink‐Jensen   +6 more
wiley   +1 more source

Directional Deep Brain Stimulation for Parkinson's Disease: Results of an International Crossover Study With Randomized, Double‐Blind Primary Endpoint

Neuromodulation: Technology at the Neural Interface, EarlyView., 2021
Abstract Objective Published reports on directional deep brain stimulation (DBS) have been limited to small, single‐center investigations. Therapeutic window (TW) is used to describe the range of stimulation amplitudes achieving symptom relief without side effects.
Alfons Schnitzler, Pablo Mir, Matthew A. Brodsky, Leonard Verhagen, Sergiu Groppa, Ramiro Alvarez, Andrew Evans, Marta Blazquez, Sean Nagel, Julie G. Pilitsis, Monika Pötter‐Nerger, Winona Tse, Leonardo Almeida, Nestor Tomycz, Joohi Jimenez‐Shahed, Witold Libionka, Fatima Carrillo, Christian J. Hartmann, Stefan Jun Groiss, Martin Glaser, Florence Defresne, Edward Karst, Binith Cheeran, Jan Vesper, for the PROGRESS Study Investigators   +24 more
wiley   +1 more source

Comparative safety signals of dopamine agonists: psychiatric and cardiovascular risks derived from FDA adverse event reporting system (FAERS) data. [PDF]

BMC Pharmacol Toxicol
Mu L, Xu J, Ye X, Jiang Y, Yi Z.
europepmc   +1 more source

Studying the suitability of hybrid micelle liquid chromatography for estimating the lipophilicity of some partial dopamine agonists used to attain the reward circuit. [PDF]

R Soc Open Sci, 2021
Wahba MEK, El Wasseef D, El Sherbiny D.
europepmc   +1 more source