Results 111 to 120 of about 282,920 (297)

Effect of single doses of droperidol or haloperidol on QTc Interval

INNOVATIONS in Pharmacy
Purpose: Droperidol and haloperidol are nonselective dopamine receptor blockers with clinical indications including postoperative nausea and vomiting and agitation.
Emily Stephens, Rachel Kahle, Lindsey Ferraro, Laura Schulz   +3 more
doaj   +1 more source

Probing the Energy Landscape of α‐Synuclein Amyloid Fibril Formation by Systematic K‐to‐Q Mutagenesis

Advanced Science, EarlyView.
We use lysine‐to‐glutamine mutations to study the effect of electrostatics on the kinetics and thermodynamics of alpha‐synuclein amyloid fibril formation. We find that mutational effects map on their structural context within fibrils and identify residues that modulate the energy landscape of alpha‐synuclein self‐assembly. Our work outlines a scalable,
Antonin Kunka, Azad Farzadfard, Jacob Aunstrup Larsen, Rasmus Krogh Norrild, Federica Saraceno, Celia Fricke, Hossein Mohammad‐Beigi, Ahmed Sadek, Jonas Folke, Susana Aznar, Alexander K. Buell   +10 more
wiley   +1 more source

Modulation of amphetamine-stimulated (transporter mediated) dopamine release in vitro by sigma2 receptor agonists and antagonists

, 1998
Some sigma receptor ligands have been shown to bind with low affinity to the dopamine transporter and to inhibit [3H]dopamine uptake. It has not previously been shown whether any of these compounds influence release of dopamine via facilitated exchange ...
Izenwasser, S, Chowdhury, I N, Werling, L L, Thompson-Montgomery, D, Deben, S E   +4 more
core   +3 more sources

Sequential Regulation of Neurovascular Bone Regeneration in Large Bone Defects Using Black Phosphorus‐Europium Nanosheet Integrated TPMS Biomimetic Scaffold with Photo‐Controlled Ion Release

Advanced Science, EarlyView.
TPBE scaffolds, in conjunction with mild photothermal effects, effectively activate the PI3K/Akt signaling cascade, thereby promoting early neuronal differentiation and neurite growth. Short‐term (12 W) in vivo implantation studies revealed no significant pathological damage to major organs, providing preliminary evidence of the material's excellent ...
Bingqian Wang, Yuping Zhang, Xiaoning Su, Ning Liu, Hui Zeng, Bo Yang, Yang Xue, Fang Guo, Changkui Liu   +8 more
wiley   +1 more source

Dopamine /

, 2005
Dopamine is a major neurotransmitter of the brain involved in the control of movement, emotion, and cognition; disturbance in dopamine function is associated with disorders like Parkinsons disease, schizophrenia and attention deficit hyperactivity ...
Dunnett, S. B.(Stephen B.)
core  

Organic Electrochemical Transistors for Neuromorphic Bioelectronics: Materials and Manufacturing Technologies

Advanced Science, EarlyView.
Organic electrochemical transistors bridge biological ionic signaling and neuromorphic computation through volumetric electrochemical gating. This review connects Organic mixed ionic–electronic conductor materials, device architectures, and manufacturing technologies to show how geometry, ion transport, and fabrication strategies program plasticity ...
Hyunjin Lee, Jihyang Park, Xinyi Wang, Yueqi Deng, Jiashu Ren, Tao Zhou   +5 more
wiley   +1 more source

Critical role of dopamine D3 receptor in structural plasticity generated by exposure to drugs of addiction in mesencephalic dopaminergic neurons

, 2013
Dopamine plays a critical role in substance misuse and addiction. Recent view on the factors involved in the maintenance of drug taking indicates in structural plasticity of neuronal network controlling rewards and motivation one of the key cellular ...
Plebani L., Spano P.F., MISSALE, Mariacristina, COLLO, Luigia Rinalda, BONO, Federica, CAVALLERI, Laura   +5 more
core  

Modulation of amphetamine-stimulated (transporter mediated) dopamine release in vitro by σ2 receptor agonists and antagonists

, 1998
Some σ receptor ligands have been shown to bind with low affinity to the dopamine transporter and to inhibit [3H]dopamine uptake. It has not previously been shown whether any of these compounds influence release of dopamine via facilitated exchange ...
Thompson-Montgomery, De Deene, Izenwasser, Sari, Sari Izenwasser, DeDeene Thompson-Montgomery, Werling, Linda L., Sophia E Deben, Iffat N Chowdhury, Deben, Sophia E., Chowdhury, Iffat N., Linda L Werling   +9 more
core   +1 more source

Decoding the Neural Circuit Underlying Context‐Cue Association in Retrieval of Morphine Reward Memory

Advanced Science, EarlyView.
Contextual cues recruit the glutamatergic vCA1–dmPFC pathway to retrieve morphine reward memory by reshaping cell‐type‐specific prefrontal microcircuit activity. Distinct regulation of PV+ and SST+ interneurons defines this hippocampal–prefrontal mechanism.
Zhifeng Shi, Guangying Li, Qian Yang, Rusun Liu, Linghan Gu, Mingmei Wang, John L. Waddington, Fuhai Ji, Xuechu Zhen   +8 more
wiley   +1 more source

Dopamine antagonists, dopamine, and duodenal ulcer

Gastroenterology, 1980
J R, Brouwers, G N, Tytgat
openaire   +2 more sources