Results 111 to 120 of about 169 (166)
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Dopamine Antagonists in ICU Delirium
New England Journal of Medicine, 2018Perhaps the most vexing problem in a patient in an intensive care unit (ICU) is an unexpected change in mental status.
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Investigational dopamine antagonists for the treatment of schizophrenia
Expert Opinion on Investigational Drugs, 2017Schizophrenia is a debilitating illness with a chronic impact on social function and daily living. Although various antipsychotics are available, there are still many challenges and unmet needs. Thus, many compounds with diverse mechanisms have been investigated, but all approved antipsychotics still require interactions with dopamine D2 receptors ...
Sheng-Min, Wang +6 more
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Antiemetic specificity of dopamine antagonists
Psychopharmacology, 1982Twelve antagonists of apomorphine-induced emesis in dogs were studied in different tests to evaluate their antiemetic specificity. Ten of these antagonists were neuroleptics: benzquinamide, clebopride, bromopride, prochlorperazine, haloperidol, chlorpromazine, thiethylperazine, metoclopramide, droperidol, and pimozide blocked conditioned responding in ...
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Dopamine Antagonists and the Development of Breast Cancer
Archives of General Psychiatry, 2002Although animal studies have raised the possibility that prolactin-elevating dopamine antagonists used to treat psychotic disorders may initiate and promote breast cancers, epidemiologic studies in humans have been limited and inconsistent.A retrospective cohort study was conducted of 52 819 women exposed and 55 289 not exposed to dopamine antagonists ...
Philip S, Wang +6 more
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The pharmacology of sulpiride—A dopamine receptor antagonist
General Pharmacology: The Vascular System, 19821. The clinical and experimental pharmacology of sulpiride, its effects on the CNS, gastrointestinal tract and cardiovascular system have been reviewed. 2. The majority of its actions are attributable to blockade of dopamine receptors. 3. Although sulpiride has a high affinity for dopamine receptors involved in emesis and prolactin secretion, it lacks ...
S E, O'Connor, R A, Brown
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Dopamine antagonists and migraine
Drug Development Research, 2007AbstractMigraine is common impairing disorder resulting from activation of the trigeminovascular system. Evidence suggests that dopaminergic mechanisms are important in migraine, including the premonitory phase. Dopamine antagonists have been used successfully as a primary therapy for migraine in urgent care settings and as adjuvant therapy on an ...
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Effects of Calcium Antagonists on the Dopamine System
Clinical Neuropharmacology, 1995Calcium channel antagonists are drugs currently used in the treatment of neurological and cardiovascular disorders and occasionally produce parkinsonism and movement disorders as a side effect. We investigated the effects of calcium channel antagonists on the pharmacology of dopamine systems in vivo and in vitro. Flunarizine, cinnarizine, and diltiazem
M A, Mena +5 more
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Dopamine Antagonist-Induced Parkinsonism
2022Abstract Drug-induced parkinsonism (DIP) can be defined as parkinsonism (at least two of four cardinal features) occurring in temporal relationship to medications known to lessen dopaminergic functioning. In fact, one of the first suggestions that dopamine may be involved in the pathogenesis of Parkinson’s disease was based on observing ...
Abdulmunaim M. Eid, William G. Ondo
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[Dopamine antagonists in anovulation?].
Zentralblatt fur Gynakologie, 1991Increased hypothalamic dopamine turnover may prevent the ovulatory LH peak by different mechanisms and may in this way result in anovulation. Ten patients with anovulatory menstrual cycles who had been treated with clomiphene citrate without success were given the dopaminolytic drug pimozide (Antalon) at a dose of 5 mg/day orally either from day 7 to ...
U, Ulrich +4 more
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DOPAMINE ANTAGONISTS FOR NAUSEA AND VOMITING
Gastroenterology Nursing, 2014The dopamine antagonists, particularly droperidol, are effective at treating N&V. Because dopamine plays many roles in the body, especially in the brain, a degree of alteration in mental status should be expected, especially with higher doses. Other less frequent side effects include QT prolongation.
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