Striatal DAT availability does not change after supraphysiological glucose loading dose in humans
Endocrine Connections, 2021 Brain dopamine neurotransmission is regulated by the dopamine transporter (DAT), which drives reuptake of extracellular dopamine into the presynaptic neurons. We hypothesized that the glucose loading dose would affect the striatal DAT avai lability. An i.
Kyoungjune Pak +6 more
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The association of DAT gene methylation with striatal DAT availability in healthy subjects
EJNMMI Research, 2021 Background DNA methylation inhibits gene expression by preventing transcription factors from binding to DNA. Functioning of nigrostriatal dopaminergic neurons is influenced by the expression of the dopamine transporter (DAT), and genetic variations in ...
Kyoungjune Pak +6 more
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Overview of the structure and function of the dopamine transporter and its protein interactions
Frontiers in Physiology, 2023 The dopamine transporter (DAT) plays an integral role in dopamine neurotransmission through the clearance of dopamine from the extracellular space. Dysregulation of DAT is central to the pathophysiology of numerous neuropsychiatric disorders and as such ...
Binod Nepal +3 more
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The Plasma Membrane-Associated GTPase Rin Interacts with the Dopamine Transporter and Is Required for Protein Kinase C-Regulated Dopamine Transporter Trafficking [PDF]
The Journal of Neuroscience, 2011 Dopaminergic signaling and plasticity are essential to numerous CNS functions and pathologies, including movement, cognition, and addiction. The amphetamine- and cocaine-sensitive dopamine (DA) transporter (DAT) tightly controls extracellular DA concentrations and half-life.
Navaroli, Deanna M. +7 more
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Ctr9, a Protein in the Transcription Complex Paf1, Regulates Dopamine Transporter Activity at the Plasma Membrane [PDF]
Journal of Biological Chemistry, 2015 Dopamine (DA) is a major regulator of sensorimotor and cognitive functions. The DA transporter (DAT) is the key protein that regulates the spatial and temporal activity of DA release into the synaptic cleft via the rapid reuptake of DA into presynaptic termini.
de Gois, Stephanie +7 more
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Iron metabolism in the social amoeba Dictyostelium discoideum: A role for ferric chelate reductases
European Journal of Cell Biology, 2022 Iron is the most abundant transition metal in all living organisms and is essential for several cellular activities, including respiration, oxygen transport, energy production and regulation of gene expression.
Barbara Peracino +4 more
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Arquivos de Neuro-Psiquiatria, 2022 Background The coexistence of amyotrophic lateral sclerosis (ALS) with clinical forms of Parkinson disease (PD), although uncommon, is found to a greater degree than one would expect by chance.
Claudio Alejandro Jimenez Monsalve +6 more
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HCO3(-)/Cl(-) exchange inactivation and reactivation during mouse oocyte meiosis correlates with MEK/MAPK-regulated Ae2 plasma membrane localization. [PDF]
PLoS ONE, 2009 BACKGROUND:Germinal Vesicle (GV) stage mouse oocytes in first meiotic prophase exhibit highly active HCO(3)(-)/Cl(-) exchange--a class of transport nearly ubiquitously involved in regulation of intracellular pH and cell volume.
Chenxi Zhou +4 more
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PLRP2 selectively localizes synaptic membrane proteins via acyl-chain remodeling of phospholipids
Journal of Lipid Research, 2020 The plasma membrane of neurons consists of distinct domains, each of which carries specialized functions and a characteristic set of membrane proteins.
Hideaki Kuge +3 more
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Altered neurocircuitry in the dopamine transporter knockout mouse brain. [PDF]
PLoS ONE, 2010 The plasma membrane transporters for the monoamine neurotransmitters dopamine, serotonin, and norepinephrine modulate the dynamics of these monoamine neurotransmitters.
Xiaowei Zhang +5 more
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