Results 101 to 110 of about 156,081 (291)

Advances in Symbiotic Bioabsorbable Devices

open access: yesAdvanced Science, EarlyView.
This review focuses on recent advances in bioabsorbable devices. This review concludes innovation at the material, device, and system levels, the significant advances toward biomedical applications. This review discusses and highlights the challenges and trends in symbiotic bioresorbable electronics, and provides a new direction for the development of ...
Chang Zhu   +3 more
wiley   +1 more source

Discrimination vs. Generation: The Machine Learning Dichotomy for Dopaminergic Hit Discovery [PDF]

open access: yesarXiv
Virtual screening plays a pivotal role in early drug discovery, traditionally dominated by physics-based methods. While these approaches offer detailed insights, they are often hindered by high computational costs, limited sampling, and forcefield inaccuracies.
arxiv  

Real‐Time Wireless Detection of Heavy Metal Ions Using a Self‐Powered Triboelectric Nanosensor Integrated with an Autonomous Thermoelectric Generator‐Powered Robotic System

open access: yesAdvanced Science, EarlyView.
This study introduces a self‐powered environmental monitoring system that integrates a triboelectric nanosensor (TENS) with a robotic hand, controlled remotely by an exo‐hand and powered by a thermoelectric generator (TEG). The fully autonomous system detects Pb2⁺, Cr⁶⁺, and As3⁺ ions in real‐time and operates without external power, ideal for remote ...
Yan‐Tsz Huang   +8 more
wiley   +1 more source

Beta band modulation by dopamine D2 receptors in the primary motor cortex and pedunculopontine nucleus in a rat model of Parkinson’s disease

open access: yesBrain Research Bulletin, 2022
Beta band (12–30 Hz) hypersynchrony within the basal ganglia-thalamocortical network has been suggested as a hallmark of Parkinson’s disease (PD) pathophysiology. Abnormal beta band oscillations are found in the pedunculopontine nucleus (PPN) and primary
Xuenan Wang   +7 more
doaj  

Structural Diversity of Mitochondria in the Neuromuscular System across Development Revealed by 3D Electron Microscopy

open access: yesAdvanced Science, EarlyView.
Mitochondria across the entire neuromuscular system have been comprehensively reconstructed at different developmental stages using 3D electron microscopy. Fundamental structural principles related to synaptic function are preserved across development, and these morphologies are adapted to ensure effective neural circuit function.
J. Alexander Bae   +9 more
wiley   +1 more source

Exploiting the Unique Properties of Lanthanide Complexes as FRET Probes: from Quantitation to Protein Dynamics

open access: yesAnalysis &Sensing, Volume 3, Issue 1, January 2023., 2023
Lanthanide complexes are ideal donors for FRET (Förster resonance energy transfer) assays with a variety of applications from easy‐to‐use quantitation of proteins to sophisticated experiments giving real‐time information on the movement of proteins. This Review article introduces the principles of using such assays before surveying the full scope of ...
Simon Wheeler, Stephen J. Butler
wiley   +1 more source

Pramipexole Upregulates Dopamine Receptor D2 and D3 Expression in Rat Striatum

open access: yesJournal of Pharmacological Sciences, 2012
Randomized clinical trials have shown that pramipexole has an antidepressant effect in patients with Parkinson’s disease. We investigated the comparative efficacy of pramipexole toward dopamine receptor D2 and D3 expression in rat brain.
Naohito Tokunaga   +7 more
doaj  

Implantable Self‐Powered Systems for Electrical Stimulation Medical Devices

open access: yesAdvanced Science, EarlyView.
In this paper, the design strategy and clinical application of ISS are discussed in depth from four aspects: the design and optimization of the energy collection module, the selection and preparation of adaptive electrode materials, the innovation of system design strategy, and the biological effect of electrical stimulation of ISS.
Xi Cui, Li Wu, Chao Zhang, Zhou Li
wiley   +1 more source

Modulation of Adenylyl Cyclase Activity in Rat Striatal Homogenate by Dopaminergic Receptors

open access: yesJournal of Pharmacological Sciences, 2008
We have characterized the modulation of adenylyl cyclase (AC) activity by ligands of dopaminergic receptors in rat striatal homogenate and compared the results with receptor-ligand binding affinities.
Argo Vonk, Reet Reinart, Ago Rinken
doaj  

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