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Dopamine receptor agonists: selectivity and dopamine D1 receptor efficacy
European Journal of Pharmacology: Molecular Pharmacology, 1990Dopamine receptor selectivity was investigated for a number of dopamine receptor agonists. In vitro, the benzazepine derivatives, e.g., SKF 38393 and SKF 75670 as well as the isoquinoline derivatives, SKF 89626 and SKF 89615, were D1 receptor-selective. All other compounds like apomorphine, CY 208-243, 6,7-ADTN and 3-PPP were either D2-selective or did
Jens Aas Jansen, Peter H. Andersen
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Schizophrenia and dopamine receptors
European Neuropsychopharmacology, 2013Schizophrenia patients are behaviorally supersensitive to dopamine-like drugs such as amphetamine or methylphenidate, meaning that patients respond to such drugs with increased psychotic symptoms, as compared to control subjects. A basis of such supersensitivity may be an increased pre-synaptic release of dopamine or a post-synaptic elevation of D2 ...
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American Journal of Hypertension, 1990
Since 1979 when two subtypes of peripheral dopamine receptors (DA1 and DA2) were first proposed, much progress has been made to confirm such a view. Cumulative experience with the dog in vivo models suggests that the potency order: fenoldopam greater than dopamine greater than dipropyl dopamine greater than apomorphine characterizes the DA1 receptor ...
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Since 1979 when two subtypes of peripheral dopamine receptors (DA1 and DA2) were first proposed, much progress has been made to confirm such a view. Cumulative experience with the dog in vivo models suggests that the potency order: fenoldopam greater than dopamine greater than dipropyl dopamine greater than apomorphine characterizes the DA1 receptor ...
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Dopamine receptors and the dopamine hypothesis of schizophrenia
Synapse, 1987AbstractThe discovery of neuroleptic drugs in 1952 provided a new strategy for seeking a biological basis of schizophrenia. This entailed a search for a primary site of neuroleptic action. The Parkinsonian effects caused by neuroleptics suggested that dopamine transmission may be disrupted by these drugs.
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Polypharmacology of dopamine receptor ligands
Progress in Neurobiology, 2016Most neurological diseases have a multifactorial nature and the number of molecular mechanisms discovered as underpinning these diseases is continuously evolving. The old concept of developing selective agents for a single target does not fit with the medical need of most neurological diseases.
S. Butini +10 more
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2001
Publisher Summary This chapter provides an overview of the role of the Dl-like dopamine receptors in nervous system function. The goal is to provide a broader, integrated overview that relates the structure and function of these interesting receptors to how the D1 receptors may interact with human neurological and psychiatric diseases. The peripheral
Cindy P. Lawler +4 more
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Publisher Summary This chapter provides an overview of the role of the Dl-like dopamine receptors in nervous system function. The goal is to provide a broader, integrated overview that relates the structure and function of these interesting receptors to how the D1 receptors may interact with human neurological and psychiatric diseases. The peripheral
Cindy P. Lawler +4 more
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Receptor reserve at striatal dopamine receptors modulating the release of [3H]dopamine
European Journal of Pharmacology, 1988Electrically stimulated release of [3H]dopamine [( 3H]DA) in slices of rat striatum was dose dependently inhibited by apomorphine (67% maximal inhibition) with an EC50 of 17 nM. DA receptor inactivation with N-ethoxycarbonyl-2-ethoxy-1,2-dihydroquinoline (EEDQ; 0.5 and 2 mg/kg) dose dependently shifted the ED50 for apomorphine to the right and reduced ...
Hideyasu Yokoo +2 more
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Caffeine mimics dopamine receptor agonists without stimulation of dopamine receptors
Neuropharmacology, 1986The purpose of this study was to examine whether caffeine stimulates dopamine (DA) receptors. The effects of caffeine on the binding of [3H]spiperone to membranes from the striatum, accumulation of L-DOPA in the striatum in mice receiving gamma-butyrolactone, and regional levels of 3,4-dihydroxyphenylacetic acid in the brain of the rat were ...
H. Watanabe, H. Uramoto
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1997
Table of Contents Preface Historical Overview: Introduction to the Dopamine Receptors Philip Seeman Gene and Promoter Structures of the Dopamine Receptors Ursula M. D'Souza Structural Basis of Dopamine Receptor Activation Irina S. Moreira, Lei Shi, Zachary Freyberg, Spencer S. Eriksen, Harel Weinstein, and Johnathan A. Javitch Dopamine Receptor Subtype-
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Table of Contents Preface Historical Overview: Introduction to the Dopamine Receptors Philip Seeman Gene and Promoter Structures of the Dopamine Receptors Ursula M. D'Souza Structural Basis of Dopamine Receptor Activation Irina S. Moreira, Lei Shi, Zachary Freyberg, Spencer S. Eriksen, Harel Weinstein, and Johnathan A. Javitch Dopamine Receptor Subtype-
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Dopamine and dopamine receptor agonists in cardiovascular therapy
Critical Care Medicine, 1990Dopamine (DA)--previously regarded simply as the precursor of norepinephrine--is now known to have its own unique effects on cardiovascular regulation which are mediated, in part, by activating specific DA receptors. DA has long been used in the treatment of shock and heart failure.
Michael B. Murphy, William J. Elliott
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