Results 1 to 10 of about 44,270 (170)

Dopamine receptor D2 regulates GLUA1-containing AMPA receptor trafficking and central sensitization through the PI3K signaling pathway in a male rat model of chronic migraine [PDF]

The Journal of Headache and Pain, 2022
Background The pathogenesis of chronic migraine remains unresolved. Recent studies have affirmed the contribution of GLUA1-containing AMPA receptors to chronic migraine.
Wei Zhang, Ming Lei, Qianwen Wen, Dunke Zhang, Guangcheng Qin, Jiying Zhou, Lixue Chen   +6 more
doaj   +2 more sources

Dopamine receptor activation elicits a possible stress-related coping behavior in a wild-caught songbird [PDF]

PeerJ, 2022
Animals experience stress throughout their lives and exhibit both physiological and behavioral responses to cope with it. The stress response can become harmful when prolonged and increasing evidence suggests that dopamine plays a critical role in ...
Melanie R. Florkowski, Jessica L. Yorzinski   +1 more
doaj   +2 more sources

Preservation of dendritic D2 receptor transmission in substantia nigra dopamine neurons with age

Scientific Reports, 2023
Substantia nigra pars compacta (SNc) dopamine neurons are required for voluntary movement and reward learning, and advanced age is associated with motor and cognitive decline.
Eva Troyano-Rodriguez, Harris E. Blankenship, Kylie Handa, Sarah Y. Branch, Michael J. Beckstead   +4 more
doaj   +1 more source

Synaptotagmin-1 is a Ca2+ sensor for somatodendritic dopamine release

Cell Reports, 2023
Summary: Modes of somatodendritic transmission range from rapid synaptic signaling to protracted regulation over distance. Somatodendritic dopamine secretion in the midbrain leads to D2 receptor-induced modulation of dopamine neurons on the timescale of ...
Joseph J. Lebowitz, Aditi Banerjee, Claire Qiao, James R. Bunzow, John T. Williams, Pascal S. Kaeser   +5 more
doaj   +1 more source

Dopamine receptors antagonistically regulate behavioral choice between conflicting alternatives in C. elegans. [PDF]

PLoS ONE, 2014
Caenorhabditis elegans is a useful model to study the neuronal or molecular basis for behavioral choice, a specific form of decision-making. Although it has been implied that both D1-like and D2-like dopamine receptors may contribute to the control of ...
Daoyong Wang, Yonglin Yu, Yinxia Li, Yang Wang, Dayong Wang   +4 more
doaj   +1 more source

Dopamine, the dopamine D2 receptor and pituitary tumours [PDF]

Clinical Endocrinology, 1991
Dopamine plays an important role in the hypothalamic-pituitary axis where its major effects are to inhibit pituitary hormone secretion and cell division. Chronic dopamine deficiency has been postulated as a cause of pituitary tumour formation and several lines of evidence exist to suggest that a functional deficiency may develop as a result of ...
D F, Wood, J M, Johnston, D G, Johnston
openaire   +2 more sources

D2-Like Receptors Mediate Dopamine-Inhibited Insulin Secretion via Ion Channels in Rat Pancreatic β-Cells

Frontiers in Endocrinology, 2020
Dopamine (DA) has a vital role in the central nervous system and also modulates lipid and glucose metabolism. The present study aimed to investigate the effect of dopamine on insulin secretion and the underlying mechanisms in rat pancreatic β-cells. Data
Mengmeng Liu, Lele Ren, Xiangqin Zhong, Yaqin Ding, Tao Liu, Tao Liu, Zhihong Liu, Zhihong Liu, Xiaohua Yang, Lijuan Cui, Lijuan Cui, Lijun Yang, Yanying Fan, Yunfeng Liu, Yi Zhang, Yi Zhang   +15 more
doaj   +1 more source

D2 dopamine receptor subtype-mediated hyperactivity and amphetamine responses in a model of ADHD

Neurobiology of Disease, 2010
Low doses of psychostimulants produce beneficial behavioral effects in ADHD patients but the mechanisms underlying the response are not understood. Here we use the hyperactive mouse mutant coloboma to identify D2-like dopamine receptor subtypes that ...
Xueliang Fan, Ming Xu, Ellen J. Hess
doaj   +1 more source

Dopamine D1 and D2 receptor immunoreactivities in the arcuate-median eminence complex and their link to the tubero-infundibular dopamine neurons

European Journal of Histochemistry, 2014
Dopamine D1 and D2 receptor immunohistochemistry and Golgi techniques were used to study the structure of the adult rat arcuate-median eminence complex, and determine the distribution of the dopamine D1 and D2 receptor immunoreactivities therein ...
W. Romero-Fernandez, D.O. Borroto-Escuela, V. Vargas-Barroso, M. Narváez, M. Di Palma, L.F. Agnati, J. Larriva Sahd, K. Fuxe   +7 more
doaj   +1 more source

D2 dopamine receptor gene and obesity [PDF]

International Journal of Eating Disorders, 1994
The prevalence of Taql A D2 dopamine receptor (DRD2) alleles was determined in 73 obese women and men. In this sample with a mean body mass index of 35.1, the A1 (minor) allele of the DRD2 gene was present in 45.2% of these nonalcohol, nondrug abusing subjects. The DRD2 A1 allele was not associated with a number of cardiovascular risk factors examined,
E P, Noble, R E, Noble, T, Ritchie, K, Syndulko, M C, Bohlman, L A, Noble, Y, Zhang, R S, Sparkes, D K, Grandy   +8 more
openaire   +2 more sources