Dopamine receptor D2 regulates GLUA1-containing AMPA receptor trafficking and central sensitization through the PI3K signaling pathway in a male rat model of chronic migraine [PDF]
The Journal of Headache and Pain, 2022 Background The pathogenesis of chronic migraine remains unresolved. Recent studies have affirmed the contribution of GLUA1-containing AMPA receptors to chronic migraine.
Wei Zhang +6 more
doaj +2 more sources
Dopamine Receptor D5 is a Modulator of Tumor Response to Dopamine Receptor D2 Antagonism. [PDF]
Clin Cancer Res, 2019 Purpose: Dopamine receptor D2 (DRD2) is a G protein–coupled receptor antagonized by ONC201, an anticancer small molecule in clinical trials for high-grade gliomas and other malignancies.
Prabhu VV +22 more
europepmc +2 more sources
Dopamine receptor D2 is correlated with gastric cancer prognosis. [PDF]
Oncol Lett, 2017 It has been reported previously that a dopamine receptor D2 (DRD2) antagonist was able to induce cancer cell apoptosis and that DRD2 was expressed at high levels in pituitary adenomas. However, the expression of DRD2 in gastric cancer and its correlation
Mu J +10 more
europepmc +2 more sources
Dopamine Receptor Subtypes, Physiology and Pharmacology: New Ligands and Concepts in Schizophrenia
Frontiers in Pharmacology, 2020 Dopamine receptors are widely distributed within the brain where they play critical modulator roles on motor functions, motivation and drive, as well as cognition.
Jean Claude Martel +1 more
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Dopamine receptor activation elicits a possible stress-related coping behavior in a wild-caught songbird [PDF]
PeerJ, 2022 Animals experience stress throughout their lives and exhibit both physiological and behavioral responses to cope with it. The stress response can become harmful when prolonged and increasing evidence suggests that dopamine plays a critical role in ...
Melanie R. Florkowski +1 more
doaj +2 more sources
Preservation of dendritic D2 receptor transmission in substantia nigra dopamine neurons with age
Scientific Reports, 2023 Substantia nigra pars compacta (SNc) dopamine neurons are required for voluntary movement and reward learning, and advanced age is associated with motor and cognitive decline.
Eva Troyano-Rodriguez +4 more
doaj +1 more source
Cocaine inhibits dopamine D2 receptor signaling via sigma-1-D2 receptor heteromers. [PDF]
PLoS ONE, 2013 Under normal conditions the brain maintains a delicate balance between inputs of reward seeking controlled by neurons containing the D1-like family of dopamine receptors and inputs of aversion coming from neurons containing the D2-like family of dopamine
Gemma Navarro +13 more
doaj +1 more source
Dopamine receptors antagonistically regulate behavioral choice between conflicting alternatives in C. elegans. [PDF]
PLoS ONE, 2014 Caenorhabditis elegans is a useful model to study the neuronal or molecular basis for behavioral choice, a specific form of decision-making. Although it has been implied that both D1-like and D2-like dopamine receptors may contribute to the control of ...
Daoyong Wang +4 more
doaj +1 more source
Frontiers in Endocrinology, 2020 Dopamine (DA) has a vital role in the central nervous system and also modulates lipid and glucose metabolism. The present study aimed to investigate the effect of dopamine on insulin secretion and the underlying mechanisms in rat pancreatic β-cells. Data
Mengmeng Liu +15 more
doaj +1 more source
Human Molecular Genetics, 2003 Although changes in nucleotide sequence affecting the composition and the structure of proteins are well known, functional changes resulting from nucleotide substitutions cannot always be inferred from simple analysis of DNA sequence.
J. Duan +6 more
semanticscholar +1 more source