Dopamine receptor D2 regulates GLUA1-containing AMPA receptor trafficking and central sensitization through the PI3K signaling pathway in a male rat model of chronic migraine [PDF]
The Journal of Headache and Pain, 2022 Background The pathogenesis of chronic migraine remains unresolved. Recent studies have affirmed the contribution of GLUA1-containing AMPA receptors to chronic migraine.
Wei Zhang +6 more
doaj +2 more sources
Dopamine Receptor D5 is a Modulator of Tumor Response to Dopamine Receptor D2 Antagonism. [PDF]
Clin Cancer Res, 2019 Purpose: Dopamine receptor D2 (DRD2) is a G protein–coupled receptor antagonized by ONC201, an anticancer small molecule in clinical trials for high-grade gliomas and other malignancies.
Prabhu VV +22 more
europepmc +2 more sources
Distinct regulation of dopamine D2S and D2L autoreceptor signaling by calcium [PDF]
eLife, 2015 D2 autoreceptors regulate dopamine release throughout the brain. Two isoforms of the D2 receptor, D2S and D2L, are expressed in midbrain dopamine neurons. Differential roles of these isoforms as autoreceptors are poorly understood.
Stephanie C Gantz +6 more
doaj +5 more sources
Dopamine receptor D2 is correlated with gastric cancer prognosis. [PDF]
Oncol Lett, 2017 It has been reported previously that a dopamine receptor D2 (DRD2) antagonist was able to induce cancer cell apoptosis and that DRD2 was expressed at high levels in pituitary adenomas. However, the expression of DRD2 in gastric cancer and its correlation
Mu J +10 more
europepmc +2 more sources
Dopamine receptor D2 confers colonization resistance via microbial metabolites. [PDF]
NatureScott SA, Fu J, Chang PV.
europepmc +2 more sources
Dopamine Receptor Subtypes, Physiology and Pharmacology: New Ligands and Concepts in Schizophrenia
Frontiers in Pharmacology, 2020 Dopamine receptors are widely distributed within the brain where they play critical modulator roles on motor functions, motivation and drive, as well as cognition.
Jean Claude Martel +1 more
doaj +2 more sources
Dopamine, the dopamine D2 receptor and pituitary tumours [PDF]
Clinical Endocrinology, 1991 Dopamine plays an important role in the hypothalamic-pituitary axis where its major effects are to inhibit pituitary hormone secretion and cell division. Chronic dopamine deficiency has been postulated as a cause of pituitary tumour formation and several lines of evidence exist to suggest that a functional deficiency may develop as a result of ...
D. F. Wood +2 more
openaire +2 more sources
Dopamine receptor activation elicits a possible stress-related coping behavior in a wild-caught songbird [PDF]
PeerJ, 2022 Animals experience stress throughout their lives and exhibit both physiological and behavioral responses to cope with it. The stress response can become harmful when prolonged and increasing evidence suggests that dopamine plays a critical role in ...
Melanie R. Florkowski +1 more
doaj +2 more sources
Preservation of dendritic D2 receptor transmission in substantia nigra dopamine neurons with age
Scientific Reports, 2023 Substantia nigra pars compacta (SNc) dopamine neurons are required for voluntary movement and reward learning, and advanced age is associated with motor and cognitive decline.
Eva Troyano-Rodriguez +4 more
doaj +1 more source