Results 91 to 100 of about 121,521 (304)

Mapping protein–protein interactions by mass spectrometry

Mass Spectrometry Reviews, EarlyView.
Abstract Protein–protein interactions (PPIs) are essential for numerous biological activities, including signal transduction, transcription control, and metabolism. They play a pivotal role in the organization and function of the proteome, and their perturbation is associated with various diseases, such as cancer, neurodegeneration, and infectious ...
Xiaonan Liu, Lawrence Abad, Lopamudra Chatterjee, Ileana M. Cristea, Markku Varjosalo   +4 more
wiley   +1 more source

Pharmacological blockade of dopamine D1- or D2-receptor in the prefrontal cortex induces attentional impairment in the object-based attention test through different neuronal circuits in mice

Molecular Brain, 2021
Dopamine is a key neurotransmitter that regulates attention through dopamine D1 and D2-receptors in the prefrontal cortex (PFC). We previously developed an object-based attention test (OBAT) to evaluate attention in mice.
Bolati Wulaer, Kazuo Kunisawa, Moeka Tanabe, Aika Yanagawa, Kuniaki Saito, Akihiro Mouri, Toshitaka Nabeshima   +6 more
doaj   +1 more source

Caffeine increases striatal dopamine D2/D3 receptor availability in the human brain

Translational Psychiatry, 2015
Caffeine, the most widely consumed psychoactive substance in the world, is used to promote wakefulness and enhance alertness. Like other wake-promoting drugs (stimulants and modafinil), caffeine enhances dopamine (DA) signaling in the brain, which it ...
N. Volkow, Gene-Jack Wang, J. Logan, D. Alexoff, J. Fowler, Panayotis K. Thanos, Christopher T. Wong, V. Casadó, S. Ferré, D. Tomasi   +9 more
semanticscholar   +1 more source

Brain state stability during working memory is explained by network control theory, modulated by dopamine D1/D2 receptor function, and diminished in schizophrenia [PDF]

arXiv, 2019
Dynamical brain state transitions are critical for flexible working memory but the network mechanisms are incompletely understood. Here, we show that working memory entails brainwide switching between activity states. The stability of states relates to dopamine D1 receptor gene expression while state transitions are influenced by D2 receptor expression
arxiv  

Reward and adversity processing circuits, their competition and interactions with dopamine and serotonin signaling [PDF]

, 2013
We propose that dACC, AI and caudolateral OFC(clOFC) project to lateral habenula (LHb) and D2 loop of ventral striatum (VS), forming a functional adversity processing circuit, directed towards inhibitory avoidance and self-control. This circuit learns what is bad or harmful to us and predicts risks, to stop us from going/moving for bad or suboptimal ...
arxiv   +1 more source

Restless Legs Syndrome and Impulsive Decision‐Making: Impact of Symptom Severity, Chronotype and Interoception

Movement Disorders Clinical Practice, EarlyView.
Abstract Background Restless Legs Syndrome (RLS) is a neurological disorder reported to be associated with impulsivity and impairments in interoception and emotional regulation. However, limited research has explored the combined influence of RLS severity, psychological factors, and chronotype on impulsive decision‐making and risk‐taking behavior in ...
Giacomo Carollo, Riccardo Quinci, Gloria Pompea Mingolla, Angela Sandri, Michele Tinazzi, Elena Antelmi   +5 more
wiley   +1 more source

Early reduced dopaminergic tone mediated by D3 receptor and dopamine transporter in absence epileptogenesis [PDF]

Epilepsia, 2019, 60 (10), pp.2128-2140
Abstract Objective In Genetic Absence Epilepsy Rats From Strasbourg ( GAERS s), epileptogenesis takes place during brain maturation and correlates with increased mRNA expression of D3 dopamine receptors (D3R). Whether these alterations are the consequence of seizure repetition or contribute to the development of epilepsy remains to be clarified.
arxiv   +1 more source

Neurovascular coupling to D2/D3 dopamine receptor occupancy using simultaneous PET/functional MRI

Proceedings of the National Academy of Sciences of the United States of America, 2013
This study employed simultaneous neuroimaging with positron emission tomography (PET) and functional magnetic resonance imaging (fMRI) to demonstrate the relationship between changes in receptor occupancy measured by PET and changes in brain activity ...
C. Sander, J. Hooker, C. Catana, M. Normandin, N. Alpert, G. Knudsen, W. Vanduffel, B. Rosen, J. Mandeville   +8 more
semanticscholar   +1 more source

Antidopaminergic Medications and Clinical Changes in Measures of Huntington's Disease: A Causal Analysis

Movement Disorders, EarlyView.
Abstract Background Antidopaminergic medications (ADM) are often used for symptom management of Huntington's disease (HD). Evidence from past research suggests that ADMs are associated with worse clinical outcomes in HD, but their impact on various domains remains underexplored.
Michal Geva, Y. Paul Goldberg, Henk Schuring, Andrew M. Tan, Jeffrey D. Long, Michael R. Hayden   +5 more
wiley   +1 more source

Kappa-opioid receptor signaling in the striatum as a potential modulator of dopamine transmission in cocaine dependence

Frontiers in Psychiatry, 2013
Cocaine addiction is accompanied by a decrease in striatal dopamine signaling, measured as a decrease in dopamine D2 receptor binding as well as blunted dopamine release in the striatum. These alterations in dopamine transmission have clinical relevance,
Pierre eTrifilieff, Pierre eTrifilieff, Diana eMartinez   +2 more
doaj   +1 more source