Modulation of Adenylyl Cyclase Activity in Rat Striatal Homogenate by Dopaminergic Receptors
Journal of Pharmacological Sciences, 2008 We have characterized the modulation of adenylyl cyclase (AC) activity by ligands of dopaminergic receptors in rat striatal homogenate and compared the results with receptor-ligand binding affinities.
Argo Vonk, Reet Reinart, Ago Rinken
doaj
Study of changes in rs2283265 polymorphisms in dopamine receptor D2 and rs27072 in dopamine transporter gene (SLC6A3) in patients with attention-deficit hyperactivity disorder. [PDF]
Iran J Child Neurol, 2022 Safavi P +5 more
europepmc +1 more source
Dissecting Dopamine D2 Receptor Signaling
, 2015 Dopamine D2 receptor (D2R) is a G protein-coupled receptor (GPCR) that activates G protein and arrestin signaling molecules. D2R antagonism has been a hallmark of antipsychotic medications for more than half a century. However, this drug-class is associated with substantial side effects that decrease quality of life and medication compliance.
openaire +3 more sources
Medicinal Research Reviews, EarlyView.ABSTRACT Photoremovable protecting groups (PPGs) offer a straightforward solution for the temporary inactivation of biologically active substrates and their subsequent controlled release by light irradiation. Their relatively easy design and mode of application have made them useful tools for studying dynamic biological processes in vitro and in vivo ...
Bence Kontra +3 more
wiley +1 more source
Pramipexole Upregulates Dopamine Receptor D2 and D3 Expression in Rat Striatum
Journal of Pharmacological Sciences, 2012 Randomized clinical trials have shown that pramipexole has an antidepressant effect in patients with Parkinson’s disease. We investigated the comparative efficacy of pramipexole toward dopamine receptor D2 and D3 expression in rat brain.
Naohito Tokunaga +7 more
doaj
PLoS ONE, 2013 The evolution of the biogenic amine signalling system in vertebrates is unclear. However, insights can be obtained from studying the structures and signalling properties of biogenic amine receptors from the protochordate, amphioxus, which is an ...
Asha L Bayliss, Peter D Evans
doaj +1 more source
The World of GPCR dimers - Mapping dopamine receptor D2 homodimers in different activation states and configuration arrangements. [PDF]
Comput Struct Biotechnol J, 2023 Bueschbell B +6 more
europepmc +1 more source
Schizophrenia: Normal Sequence in the Dopamine D2 Receptor Region that Couples to G-Proteins. DNA Polymorphisms in D2 [PDF]
, 1993 Philip Seeman +6 more
openalex +1 more source
Molecular Tools to Study and Control Dopaminergic Neurotransmission With Light
Medicinal Research Reviews, EarlyView.ABSTRACT Dopaminergic neurotransmission is involved in several important brain functions, such as motor control, learning, reward‐motivated behavior, and emotions. Dysfunctions of dopaminergic system may lead to the development of various neurological and psychiatric disorders, like Parkinson's disease, schizophrenia, depression, and addictions ...
Galyna Maleeva +5 more
wiley +1 more source
Expression, correlation, and prognostic significance of different nicotinic acetylcholine receptors, programed death ligand 1, and dopamine receptor D2 in lung adenocarcinoma. [PDF]
Front Oncol, 2022 Pal K +8 more
europepmc +1 more source