Pramipexole Upregulates Dopamine Receptor D2 and D3 Expression in Rat Striatum
Journal of Pharmacological Sciences, 2012 Randomized clinical trials have shown that pramipexole has an antidepressant effect in patients with Parkinson’s disease. We investigated the comparative efficacy of pramipexole toward dopamine receptor D2 and D3 expression in rat brain.
Naohito Tokunaga +7 more
doaj
Expression, correlation, and prognostic significance of different nicotinic acetylcholine receptors, programed death ligand 1, and dopamine receptor D2 in lung adenocarcinoma. [PDF]
Front Oncol, 2022 Pal K +8 more
europepmc +1 more source
Schizophrenia: Normal Sequence in the Dopamine D2 Receptor Region that Couples to G-Proteins. DNA Polymorphisms in D2 [PDF]
, 1993 Philip Seeman +6 more
openalex +1 more source
Progress on the development of Class A GPCR‐biased ligands
British Journal of Pharmacology, EarlyView.Class A G protein‐coupled receptors (GPCRs) continue to garner interest for their essential roles in cell signalling and their importance as drug targets. Although numerous drugs in the clinic target these receptors, over 60% GPCRs remain unexploited. Moreover, the adverse effects triggered by the available unbiased GPCR modulators, limit their use and
Paula Morales +20 more
wiley +1 more source
Total Barley Maiya Alkaloids Prevent Increased Prolactin Levels Caused by Antipsychotic Drugs and Reduce Dopamine Receptor D2 via Epigenetic Mechanisms. [PDF]
Front Pharmacol, 2022 Cao YL +10 more
europepmc +1 more source
Molecular De Novo Design through Deep Reinforcement Learning [PDF]
arXiv, 2017 This work introduces a method to tune a sequence-based generative model for molecular de novo design that through augmented episodic likelihood can learn to generate structures with certain specified desirable properties. We demonstrate how this model can execute a range of tasks such as generating analogues to a query structure and generating ...
arxiv
Preclinical models for evaluating psychedelics in the treatment of major depressive disorder
British Journal of Pharmacology, EarlyView.Psychedelic drugs have seen a resurgence in interest as a next generation of psychiatric medicines with potential as rapid‐acting antidepressants (RAADs). Despite promising early clinical trials, the mechanisms which underlie the effects of psychedelics are poorly understood.
Laith Alexander +5 more
wiley +1 more source
Resetting the circadian clock in cultured Xenopus eyecups: regulation of retinal melatonin rhythms by light and D2 dopamine receptors [PDF]
, 1991 GM Cahill, JC Besharse
openalex +1 more source
British Journal of Pharmacology, EarlyView.Abstract Background and Purpose Preclinical studies suggest that highly selective dopamine D3 receptor (D3R) antagonists or partial agonists hold promise for treating substance use disorders. However, their limited effectiveness in reducing cocaine self‐administration is a major drawback.
Omar Soler‐Cedeño +9 more
wiley +1 more source
Dopamine receptor D2, but not D1, mediates the reward circuit from the ventral tegmental area to the central amygdala, which is involved in pain relief. [PDF]
Mol Pain, 2022 Huang M +8 more
europepmc +1 more source