Results 161 to 170 of about 121,521 (304)

Impact of Opioid and Cannabis Use on Low‐Dose Amitriptyline Efficacy in Cyclical Vomiting Syndrome: A Real‐World Study in the United Kingdom

Neurogastroenterology &Motility, EarlyView.
This article presents the outcomes of a three‐tiered outpatient treatment algorithm for the prophylactic management of cyclical vomiting syndrome (CVS). Three key messages: (1) 61% of patients responded to the treatment algorithm, (2) opioid cessation was associated with clinical response to the treatment algorithm (p = 0.03), and (3) a low‐dose ...
Mohsin F. Butt, Francesca Cefalo, Caterina Sbarigia, Arkadeep Dhali, Maura Corsetti   +4 more
wiley   +1 more source

The Fat Mass and Obesity-Associated Protein (FTO) Regulates Locomotor Responses to Novelty via D2R Medium Spiny Neurons

Cell Reports, 2019
Summary: Variations in the human FTO gene have been linked to obesity and altered connectivity of the dopaminergic neurocircuitry. Here, we report that fat mass and obesity-associated protein (FTO) in dopamine D2 receptor-expressing medium spiny neurons (
Johan Ruud, Jens Alber, Anna Tokarska, Linda Engström Ruud, Hendrik Nolte, Nasim Biglari, Rachel Lippert, Änne Lautenschlager, Przemysław E. Cieślak, Łukasz Szumiec, Martin E. Hess, Hella S. Brönneke, Marcus Krüger, Hans Nissbrandt, Tatiana Korotkova, Gilad Silberberg, Jan Rodriguez Parkitna, Jens C. Brüning   +17 more
doaj  

Targeting dopamine receptor D2 as a novel therapeutic strategy in endometrial cancer. [PDF]

J Exp Clin Cancer Res, 2021
Pierce SR, Fang Z, Yin Y, West L, Asher M, Hao T, Zhang X, Tucker K, Staley A, Fan Y, Sun W, Moore DT, Xu C, Tsai YH, Parker J, Prabhu VV, Allen JE, Lee D, Zhou C, Bae-Jump V.   +19 more
europepmc   +1 more source

Purification and characterization of the D2-dopamine receptor from bovine anterior pituitary.

, 1988
Susan E. Senogles, N Amlaiky, Pierre Falardeau, Marc G. Caron   +3 more
openalex   +1 more source

Functionally Antagonistic Transcription Factors IRF1 and IRF2 Regulate the Transcription of the Dopamine Receptor D2 Gene Associated with Aggressive Behavior of Weaned Pigs. [PDF]

Biology (Basel), 2022
Zhao J, Gao S, Guo Y, Xu Q, Liu M, Zhang C, Cheng M, Zhao X, Schinckel AP, Zhou B.   +9 more
europepmc   +1 more source

Mitochondrial control of ciliary gene expression and structure in striatal neurons

The Journal of Physiology, EarlyView.
Abstract figure legend Neurons drive animal behaviour by receiving and transmitting information and require energy, primarily supplied by mitochondria, to function. Additionally, neurons need to sense environmental changes to adapt, a function that is locally played by the primary cilia.
Dogukan H. Ulgen, Alessandro Chioino, Olivia Zanoletti, Albert Quintana, Elisenda Sanz, Carmen Sandi   +5 more
wiley   +1 more source

D2-like dopamine receptors mediate the response to amphetamine in a mouse model of ADHD

Neurobiology of Disease, 2007
The mechanisms underlying the effects of psychostimulants in attention deficit hyperactivity disorder (ADHD) are not well understood, but indirect evidence implicates D2 dopamine receptors. Here we dissect the components of dopaminergic neurotransmission
Xueliang Fan, Ellen J. Hess
doaj  

Epidermal growth factor receptor as a molecular determinant of glioblastoma response to dopamine receptor D2 inhibitors. [PDF]

Neuro Oncol, 2021
He Y, Li J, Koga T, Ma J, Dhawan S, Suzuki Y, Furnari F, Prabhu VV, Allen JE, Chen CC.   +9 more
europepmc   +1 more source

Leveraging 13C NMR spectroscopic data derived from SMILES to predict the functionality of small biomolecules by machine learning: a case study on human Dopamine D1 receptor antagonists [PDF]

arXiv
This study contributes to ongoing research which aims to predict small biomolecule functionality using Carbon-13 Nuclear Magnetic Resonance ($^{13}$C NMR) spectrum data and machine learning (ML). The approach was demonstrated using a bioassay on human dopamine D1 receptor antagonists.
arxiv  

Spiking Patterns in the Globus Pallidus Highlight Convergent Neural Dynamics across Diverse Genetic Dystonia Syndromes

Annals of Neurology, Volume 97, Issue 5, Page 826-844, May 2025.
Objective Genetic dystonia is a complex movement disorder with diverse clinical manifestations resulting from pathogenic mutations in associated genes. A recent paradigm shift emphasizes the functional convergence among dystonia genes, hinting at a shared pathomechanism. However, the neural dynamics supporting this convergence remain largely unexplored.
Ahmet Kaymak, Fabiana Colucci, Mahboubeh Ahmadipour, Nico Golfrè Andreasi, Sara Rinaldo, Zvi Israel, David Arkadir, Roberta Telese, Vincenzo Levi, Giovanna Zorzi, Jacopo Carpaneto, Miryam Carecchio, Holger Prokisch, Michael Zech, Barbara Garavaglia, Hagai Bergman, Roberto Eleopra, Alberto Mazzoni, Luigi M. Romito   +18 more
wiley   +1 more source