Results 171 to 180 of about 121,521 (304)

Developing Photoaffinity Probes for Dopamine Receptor D2 to Determine Targets of Parkinson's Disease Drugs. [PDF]

open access: yesACS Chem Neurosci, 2022
Kim ST   +6 more
europepmc   +1 more source

Purine Metabolism and Dystonia: Perspectives of a Long‐Promised Relationship

open access: yesAnnals of Neurology, Volume 97, Issue 5, Page 809-825, May 2025.
Purine pool imbalance in purine metabolism disorders, such as Lesch–Nyhan disease, intersects with dystonia pathogenesis. The recent discovery of gain‐of‐function IMPDH2 pathogenic variants in patients with prominent dystonic manifestations provides new insights into the link between dystonia and purinergic system defects.
Ugo Sorrentino   +4 more
wiley   +1 more source

Heterogenous Dopamine D2 Receptor Subtype Messenger Ribonucleic Acid Expression in Clinically Nonfunctioning Pituitary Adenomas1 [PDF]

open access: bronze, 1998
Ulrich Renner   +8 more
openalex   +1 more source

Role of Serum Brain‐Derived Neurotrophic Factor as a Biomarker of Chronic Pain in Older Adults

open access: yesEuropean Journal of Pain, Volume 29, Issue 5, May 2025.
ABSTRACT Background Serum brain‐derived neurotrophic factor (BDNF) has emerged as a promising biomarker for chronic pain (CP) research and treatment. Yet, most human studies have been limited by small sample sizes, inadequate control of confounders and a lack of focus on sex and mental health differences.
R. Ortolá   +9 more
wiley   +1 more source

No association of dopamine D2 receptor molecular variant Cys311 and schizophrenia in Chinese patients [PDF]

open access: green, 1996
Chia‐Hsiang Chen   +2 more
openalex   +1 more source

Astrocytes Mediate Psychostimulant‐Induced Alterations of Spike‐Timing Dependent Synaptic Plasticity

open access: yesGlia, Volume 73, Issue 5, Page 1051-1067, May 2025.
Main Points Cocaine and amphetamine stimulates astrocytes and downregulates the GLT‐1. The dysfunction in GLT‐1 modify EPSP kinetics and modulate STDP, switching LTP to LTD in psychostimulant‐treated mice. These effects were restored by upregulation of GLT‐1.
Samuel Alberquilla   +7 more
wiley   +1 more source

Predicting novel pharmacological activities of compounds using PubChem IDs and machine learning (CID-SID ML model) [PDF]

open access: yesarXiv
Significance and Object: The proposed methodology aims to provide time- and cost-effective approach for the early stage in drug discovery. The machine learning models developed in this study used only the identification numbers provided by PubChem.
arxiv  

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