Results 191 to 200 of about 99,139 (322)

Dopamine D2 receptor [PDF]

open access: yesScience-Business eXchange, 2013
openaire   +1 more source

Exploring Adjunctive Novel Therapeutic Approach of KarXT (Xanomeline‐Trospium Chloride) for Managing Psychotic Symptoms in Patients With Schizophrenia and Alzheimer's Disease

open access: yesBrain and Behavior, Volume 16, Issue 1, January 2026.
An overview of the mechanism of action, clinical trials, and classical findings of KarXT for the management of psychotic symptoms in patients with schizophrenia and alzheimer's disease. ABSTRACT Background Acute psychotic symptoms like delusions and hallucinations are of major concern while treating patients with schizophrenia and alzheimer's psychosis,
Ashir Kanwal   +7 more
wiley   +1 more source

Developing Photoaffinity Probes for Dopamine Receptor D2 to Determine Targets of Parkinson's Disease Drugs. [PDF]

open access: yesACS Chem Neurosci, 2022
Kim ST   +6 more
europepmc   +1 more source

Altered Functional Specialization and Interhemispheric Coordination in Rhegmatogenous Retinal Detachment: Associations With Gene Expression, Neurotransmitter Receptor Distribution, and SVM–SHAP Classification

open access: yesCNS Neuroscience &Therapeutics, Volume 32, Issue 1, January 2026.
Autonomy Index (AI) and Connective Flexibility of Homotopic voxels (CFH) were derived from resting‐state fMRI data following standard preprocessing. These functional metrics were computed based on the AAL90 atlas to characterize intrinsic activity and interhemispheric coordination patterns in RRD patients.
Yu Ji, Yuan‐Yuan Wang, Xiao‐Rong Wu
wiley   +1 more source

Striatal Dopamine D2 Receptor Occupancy Induced by Daily Application of Blonanserin Transdermal Patches: Phase II Study in Japanese Patients With Schizophrenia [PDF]

open access: gold, 2020
Hironori Nishibe   +6 more
openalex   +1 more source

Striatal dopamine D2-like receptors availability in obesity and its modulation by bariatric surgery: a systematic review and meta-analysis [PDF]

open access: gold, 2023
Gabriela Ribeiro   +5 more
openalex   +1 more source

Spirocyclic Diamine Scaffolds for Medicinal Chemistry

open access: yesHelvetica Chimica Acta, Volume 109, Issue 1, January 2026.
Here we enumerated 391 spirocyclic diamine drug scaffolds with ring sizes four to eight and found that most of them are unknown. We prepared four novel such spirocycles and discovered a micromolar inhibitor of the M4 muscarinic receptor. ABSTRACT Medicinal chemistry requires the exploration of structurally diverse compound families to expand the ...
Aline Carrel   +3 more
wiley   +1 more source

Population Pharmacokinetic Model‐Based Dose Selection of Extended‐Release Injectable Olanzapine (TV‐44749) for Subcutaneous Use in Phase 3 Clinical Trial in Adults with Schizophrenia

open access: yesThe Journal of Clinical Pharmacology, Volume 66, Issue 1, January 2026.
Abstract TV‐44749 is a long‐acting subcutaneous (SC) injectable olanzapine based on a novel copolymer drug delivery technology ensuring controlled olanzapine release over the dosing interval. TV‐44749's formulation and SC route of administration aim to eliminate the causes of post‐injection delirium/sedation syndrome (PDSS) that may occur with the ...
Itay Perlstein   +6 more
wiley   +1 more source

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