Results 251 to 260 of about 48,073 (302)

The Physiological Role of Dopamine D2 Receptors

1997
Publisher Summary Interest lies in the study of the physiological activity of D2 receptors that are abundantly expressed in the striatum, substantia nigra, and hypophysis. Two isoforms of this receptor have been described that differ by their coupling characteristics to G-proteins in vitro.
Saiardi Adolfo, Samad Tarek Abdel, Picetti Roberto, Bozzi Yuri, Baik JaHyun, Borrelli Emiliana   +5 more
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The Dopamine D2 Receptor

1992
Dopamine is the dominant catecholamine neurotransmitter in the mammalian brain. It is found throughout the entire central nervous system, but is predominant in the nigrostriatal, mesolimbic, and tuberoinfundibular tracts (Creese et al., 1983). Dopamine exerts its effects through binding to two types of receptor, the D1 and D2 receptors (Kebabian and ...
Hubert H.M. Van Tol, Paul R. Albert, Olivier Civelli, James R. Bunzow, David K. Grandy   +4 more
openaire   +2 more sources

D2 and D4 dopamine receptor polymorphisms and personality [PDF]

American Journal of Medical Genetics, 1998
The relationship of various dimensions of temperament, measured by the Tridimensional Personality Questionnaire (TPQ), to polymorphisms of the D2 dopamine receptor (DRD2) and D4 dopamine receptor (DRD4) genes was determined in 119 healthy Caucasian boys who had not yet begun to consume alcohol and other drugs of abuse.
Terry Ritchie, Ernest P. Noble, Tulin Ozkaragoz, Xuxian Zhang, Robert S. Sparkes, Thomas R. Belin   +5 more
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Synthesis and processing of D2 dopamine receptors

Biochemistry, 1993
Dopamine receptors belong to a superfamily of neurotransmitter receptors that are functionally coupled to guanine nucleotide binding proteins. In this study, we have used Chinese hamster ovary (CHO) cells stably transfected with the rat D2L receptor, in conjunction with specific anti-peptide antibodies that we have developed, in order to visualize this
David R. Sibley, Fishburn Cs, Sara Fuchs, Carol David, Monsma Fj   +4 more
openaire   +3 more sources

D2 dopamine receptor gene and alcoholism

Journal of Psychiatric Research, 1993
An allelic association of the TAQ I A1 D2 dopamine receptor gene polymorphism has been found in homogeneous populations of alcoholics from France.
Didier Castelnau, Yves Leclaire, Jean-Claude Champiat, Michel Selin, Mokrane Abbar, Marie Gaelle Leroux, Gilles Waksman, Jacques Mallet, Andree Madec, Stéphane Amadéo, Marie Line Fourcade, Annie Brethome, Jean-Luc Venisse   +12 more
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Dopamine D2 Receptors in Signal Transduction and Behavior

Critical Reviews™ in Neurobiology, 1997
The dopamine D2 receptor belongs to the family of seven transmembrane domain G-protein-coupled receptors and is highly expressed in the central nervous system and the pituitary gland. The binding of dopamine to the D2 receptor is crucial for the regulation of diverse physiological functions, such as the control of locomotor activity and the synthesis ...
Picetti, R. Saiardi A, Abdel Samad T, Bozzi Y, Baik JH, Borrelli E.   +5 more
openaire   +5 more sources

The dopamine D2 antagonist remoxipride acts in vivo on a subpopulation of dopamine D2 receptors

Neuroscience, 1994
Dopamine D2 receptors were inactivated by N-ethoxycarbonyl-2-ethoxy-1,2,-dihydroxy-quinoline (EEDQ) (6 mg/kg i.p.). The reduction in dopamine receptors was monitored by quantitative receptor autoradiography using [125I]iodosulpiride or [3H]raclopride as radioligands.
L. Rosén, Kjell Fuxe, Sven-Ove Ögren
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The Dopamine D2 Receptor Gene and Alcoholism

JAMA, 1991
To the Editor. — Two JAMA reports differ in describing the association between a D2dopamine receptor gene allele and alcoholism. Blum et al1found that the Al allele of the D2gene was present in a significantly higher percentage of 35 alcoholics (69%) than in 35 nonalcoholic controls (20%).
Bruce F. O'Hara, Stevens S. Smith, David A. Gorelick, George R. Uhl   +3 more
openaire   +4 more sources

Dopamine D2 Receptor and Tourette's Syndrome

Archives of Neurology, 1995
I was pleased to see the study by Gelernter et al 1 concerning the role of the dopamine D 2 receptor ( DRD2 ) gene in Tourette syndrome (TS) because the authors so nicely verified our previous studies demonstrating a role the DRD2 gene in TS and because they illustrated some of the issues concerning association vs linkage studies in neuropsychiatric ...
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D2 dopamine receptor antisense oligodeoxynucleotide inhibits the synthesis of a functional pool of D2 dopamine receptors.

Molecular Pharmacology, 1995
In vivo administration of an antisense oligonucleotide targeted toward the D2 dopamine (DA) receptor mRNA (D2 AS) markedly inhibited D2 receptor-mediated behaviors but produced only a relatively small reduction in the levels of D2 DA receptors in mouse striatum.
Z H, Qin, L W, Zhou, S P, Zhang, Y, Wang, B, Weiss   +4 more
openaire   +2 more sources