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Distinct dopamine D2 receptor antagonists differentially impact D2 receptor oligomerization

, 2021
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Dopamine D2 receptor signaling dynamics of dopamine D2-neurotensin 1 receptor heteromers

Biochemical and Biophysical Research Communications, 2013
Biochemical, histochemical and coimmunoprecipitation experiments have indicated the existence of antagonistic dopamine D2 (D2R) and neurotensin 1 (NTS1R) receptor-receptor interactions in the dorsal and ventral striatum indicating a potential role of these receptor-receptor interactions in Parkinson's disease and schizophrenia.
Borroto Escuela D. O., RAVANI, Annalisa, Tarakanov A. O., Brito I., Narvaez M., Romero Fernandez W., Corrales F., Agnati L. F., TANGANELLI, Sergio, FERRARO, Luca Nicola, Fuxe K.   +10 more
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Olfactory receptor neurons express D2 dopamine receptors

The Journal of Comparative Neurology, 1999
The role of the dopamine (DA) in the olfactory bulb (OB) was explored by determining which of the potential target cells express dopamine receptors (DARs). Previously, it was reported that D2-like DAR (D2, D3, and D4 subtypes) radioligand binding is restricted to the outer layers of the OB.
N L, Koster, A B, Norman, N M, Richtand, W T, Nickell, A C, Puche, S K, Pixley, M T, Shipley   +6 more
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D2 dopamine receptor gene and alcoholism

Journal of Psychiatric Research, 1993
An allelic association of the TAQ I A1 D2 dopamine receptor gene polymorphism has been found in homogeneous populations of alcoholics from France.
Stéphane Amadéo, Mokrane Abbar, Marie Line Fourcade, Gilles Waksman, Marie Gaelle Leroux, Andree Madec, Michel Selin, Jean-Claude Champiat, Annie Brethome, Yves Leclaire, Didier Castelnau, Jean-Luc Venisse, Jacques Mallet   +12 more
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Solubilized dopamine/neuroleptic receptors (D2-type)

Progress in Neuro-Psychopharmacology, 1981
Abstract 1. 1. Dopamine (D 2 -type) receptors were solubilized from striatum of three species (human, canine, calf) using digitonin. 2. 2. The receptors were labeled with 3 H-spiperone and assayed by Sephadex G-50 columns or polyethylene glycol precipitation. 3. 3. The soluble receptors from canine and human tissue had similar K d 's and
B K, Madras, A, Davis, B, Chan, P, Seeman   +3 more
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Cerebellar dopamine D2 receptors regulate social behaviors

Nature Neuroscience, 2022
The cerebellum, a primary brain structure involved in the control of sensorimotor tasks, also contributes to higher cognitive functions including reward, emotion and social interaction. Although the regulation of these behaviors has been largely ascribed to the monoaminergic system in limbic regions, the contribution of cerebellar dopamine signaling in
Laura Cutando, Emma Puighermanal, Laia Castell, Pauline Tarot, Morgane Belle, Federica Bertaso, Margarita Arango-Lievano, Fabrice Ango, Marcelo Rubinstein, Albert Quintana, Alain Chédotal, Manuel Mameli, Emmanuel Valjent   +12 more
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The Dopamine D2 Receptor

1992
Dopamine is the dominant catecholamine neurotransmitter in the mammalian brain. It is found throughout the entire central nervous system, but is predominant in the nigrostriatal, mesolimbic, and tuberoinfundibular tracts (Creese et al., 1983). Dopamine exerts its effects through binding to two types of receptor, the D1 and D2 receptors (Kebabian and ...
Olivier Civelli, James Bunzow, Paul Albert, Hubert H. M. Van Tol, David Grandy   +4 more
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Dopamine D2 Receptor Dimers and Receptor-Blocking Peptides

Biochemical and Biophysical Research Communications, 1996
Dopamine D2 receptors exist as dimers in whole cell lysate, crude membranes prepared from human caudate, and following solubilization and immunoprecipitation of the receptor from these tissues. Photoaffinity labelling experiments confirmed that D2 receptors exist either as monomers that are selective targets for spiperone or as dimers that are targets ...
G Y, Ng, B F, O'Dowd, S P, Lee, H T, Chung, M R, Brann, P, Seeman, S R, George   +6 more
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D2 dopamine receptor involvement in spinal dopamine-produced antinociception

Life Sciences, 1992
Experiments were performed on 79 lightly pentobarbital-anesthetized rats. Rats displayed a dose-dependent increase in tail-flick latencies following the injection of dopamine (DA) into the lumbar subarachnoid space through an intrathecal tube. Sulpiride, a D2-subtype receptor antagonist, antagonized the DA-induced analgesia (antinociceptive) effect ...
Q S, Liu, J T, Qiao, N, Dafny
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The Physiological Role of Dopamine D2 Receptors

1997
Publisher Summary Interest lies in the study of the physiological activity of D2 receptors that are abundantly expressed in the striatum, substantia nigra, and hypophysis. Two isoforms of this receptor have been described that differ by their coupling characteristics to G-proteins in vitro.
Saiardi Adolfo, Samad Tarek Abdel, Picetti Roberto, Bozzi Yuri, Baik JaHyun, Borrelli Emiliana   +5 more
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