Results 51 to 60 of about 44,270 (170)

Kappa-opioid receptor signaling in the striatum as a potential modulator of dopamine transmission in cocaine dependence

Frontiers in Psychiatry, 2013
Cocaine addiction is accompanied by a decrease in striatal dopamine signaling, measured as a decrease in dopamine D2 receptor binding as well as blunted dopamine release in the striatum. These alterations in dopamine transmission have clinical relevance,
Pierre eTrifilieff, Pierre eTrifilieff, Diana eMartinez   +2 more
doaj   +1 more source

A Novel Dopamine Receptor Signaling Unit in Brain: Heterooligomers of D1 And D2 Dopamine Receptors

The Scientific World Journal, 2007
The ability of G protein coupled receptors to heterooligomerize and create novel signaling complexes has demonstrated the tremendous potential of these receptors to access diverse signaling cascades, as well as to modulate the nature of the transduced ...
Susan R. George, Brian F. O'Dowd
doaj   +1 more source

Dichotomous Dopaminergic Control of Ventral Pallidum Neurons

Frontiers in Cellular Neuroscience, 2018
The ventral pallidum (VP) is crucially involved in reward processing. Dopaminergic afferents reach the VP from the ventral tegmental area (VTA). Recent in vivo studies suggest dopamine application increase the firing in the VP.
Martin Clark, Enrico Bracci
doaj   +1 more source

D2-like dopamine receptors mediate the response to amphetamine in a mouse model of ADHD

Neurobiology of Disease, 2007
The mechanisms underlying the effects of psychostimulants in attention deficit hyperactivity disorder (ADHD) are not well understood, but indirect evidence implicates D2 dopamine receptors. Here we dissect the components of dopaminergic neurotransmission
Xueliang Fan, Ellen J. Hess
doaj   +1 more source

Dopamine D2 antagonist-induced striatal Nur77 expression requires activation of mGlu5 receptors by cortical afferents

Frontiers in Pharmacology, 2012
Dopamine D2 receptor antagonists modulate gene transcription in the striatum. However, the molecular mechanism underlying this effect remains elusive. Here we used the expression of Nur77, a transcription factor of the orphan nuclear receptor family, as ...
Jérôme eMaheux, Michel eSt-Hilaire, David eVoyer, Emanuele eTirotta, Emiliana eBorrelli, Claude eRouillard, Pierre-Paul eRompré, Daniel eLévesque   +7 more
doaj   +1 more source

Involvement of Dopaminergic Receptor Signaling in the Effects of Glutamatergic Receptor Antagonists on Conditioned Place Aversion Induced by Naloxone in Single-Dose Morphine-Treated Rats

Journal of Pharmacological Sciences, 2011
.: A better understanding of the neurochemical mechanisms mediating the aversive consequences of drug withdrawal is important for understanding drug addiction. We previously demonstrated that the inhibitory effect of glutamate receptor antagonists on the
Yoichi Kawasaki, Hiroaki Araki, Katsuya Suemaru, Yoshihisa Kitamura, Yutaka Gomita, Toshiaki Sendo   +5 more
doaj   +1 more source

The dopamine D1 receptor is expressed and induces CREB phosphorylation and MUC5AC expression in human airway epithelium

Respiratory Research, 2018
Background Dopamine receptors comprise two subgroups, Gs protein-coupled “D1-like” receptors (D1, D5) and Gi-coupled “D2-like” receptors (D2, D3, D4). In airways, both dopamine D1 and D2 receptors are expressed on airway smooth muscle and regulate airway
Nao Matsuyama, Sumire Shibata, Atsuko Matoba, Tada-aki Kudo, Jennifer Danielsson, Atsushi Kohjitani, Eiji Masaki, Charles W. Emala, Kentaro Mizuta   +8 more
doaj   +1 more source

CHL1 depletion affects dopamine receptor D2-dependent modulation of mouse behavior. [PDF]

Front Behav Neurosci, 2023
Fernandes L, Kleene R, Congiu L, Freitag S, Kneussel M, Loers G, Schachner M.   +6 more
europepmc   +1 more source

A novel dopamine receptor D2 antagonist (ONC206) potentiates the effects of olaparib in endometrial cancer. [PDF]

Cancer Biol Ther, 2023
Paraghamian SE, Qiu J, Hawkins GM, Zhao Z, Sun W, Fan Y, Zhang X, Suo H, Hao T, Prabhu VV, Allen JE, Zhou C, Bae-Jump V.   +12 more
europepmc   +1 more source

Effect of risperidone on morphine-induced conditioned place preference and dopamine receptor D2 gene expression in male rat hippocampus. [PDF]

Brain Behav, 2023
Arani ZM, Heidariyeh N, Ghavipanjeh G, Lotfinia M, Banafshe HR.   +4 more
europepmc   +1 more source