Results 51 to 60 of about 121,521 (304)

An Increase in Peripheral Temperature following Cocaine Administration Is Mediated through Activation of Dopamine D2 Receptor in Rats

Life, 2022
Drug addiction has become a worldwide problem, affecting millions of people across the globe. While the majority of mechanistic studies on drug addiction have been focused on the central nervous system, including the mesolimbic dopamine system, the ...
Suchan Chang, Yeonhee Ryu, Se Kyun Bang, Han Byeol Jang, DanBi Ahn, Hyung Kyu Kim, Hubert Lee, Sang Chan Kim, Bong Hyo Lee, Hee Young Kim   +9 more
doaj   +1 more source

DiffDTM: A conditional structure-free framework for bioactive molecules generation targeted for dual proteins [PDF]

arXiv, 2023
Advances in deep generative models shed light on de novo molecule generation with desired properties. However, molecule generation targeted for dual protein targets still faces formidable challenges including protein 3D structure data requisition for model training, auto-regressive sampling, and model generalization for unseen targets.
arxiv  

STRUCTURE OF THE D2 DOPAMINE RECEPTOR BOUND TO THE ATYPICAL ANTIPSYCHOTIC DRUG RISPERIDONE

Nature, 2018
Dopamine is a neurotransmitter that has been implicated in processes as diverse as reward, addiction, control of coordinated movement, metabolism and hormonal secretion.
Sheng Wang, T. Che, A. Levit, B. Shoichet, Daniel Wacker, B. Roth   +5 more
semanticscholar   +1 more source

Synthetic Approaches to Molecule‐2D Transition Metal Dichalcogenide Heterostructures

Angewandte Chemie International Edition, EarlyView.
The integration of 2D materials with molecular chemistry enables precise control over material properties and enhances their functionality. Molecule‐transition metal dichalcogenide (mTMD) heterostructures are particularly promising due to their unique electronic, optical, and catalytic properties.
Sofiia Zuieva, Xin Chen
wiley   +1 more source

Pergolide Mesilate May Improve Fatigue in Patients with Parkinson’s Disease

Behavioural Neurology, 2002
Objectives: Fatigue is a complaint frequently encountered among patients with Parkinson’s disease (PD). Considering the possible relationship between fatigue and dopaminergic dysfuncion, we investigated the effect of pergolide mesilate (a D2 and D1 ...
Kazuo Abe, Mayako Takanashi, Takehiko Yanagihara, Sabro Sakoda   +3 more
doaj   +1 more source

Central dopamine D2 receptors regulate plasma glucose levels in mice through autonomic nerves

Scientific Reports, 2020
Recent evidence suggests that the central nervous system (CNS) regulates plasma glucose levels, but the underlying mechanism is unclear. The present study investigated the role of dopaminergic function in the CNS in regulation of plasma glucose levels in
Hiroko Ikeda, Naomi Yonemochi, Risa Mikami, Manabu Abe, Meiko Kawamura, Rie Natsume, Kenji Sakimura, John L. Waddington, Junzo Kamei   +8 more
doaj   +1 more source

Characterisation of the interaction of the C-terminus of the dopamine D2 receptor with neuronal calcium sensor-1. [PDF]

PLoS ONE, 2011
NCS-1 is a member of the neuronal calcium sensor (NCS) family of EF-hand Ca(2+) binding proteins which has been implicated in several physiological functions including regulation of neurotransmitter release, membrane traffic, voltage gated Ca(2 ...
Lu-Yun Lian, Sravan R Pandalaneni, Pryank Patel, Hannah V McCue, Lee P Haynes, Robert D Burgoyne   +5 more
doaj   +1 more source

Activation of D2 dopamine receptor-expressing neurons in the nucleus accumbens increases motivation

Nature Communications, 2016
Striatal dopamine receptor D1-expressing neurons have been classically associated with positive reinforcement and reward, whereas D2 neurons are associated with negative reinforcement and aversion. Here we demonstrate that the pattern of activation of D1
C. Soares-Cunha, B. Coimbra, A. David-Pereira, S. Borges, L. Pinto, Patrício Costa, N. Sousa, A. Rodrigues   +7 more
semanticscholar   +1 more source

Deciphering the skeletal interoceptive circuitry to control bone homeostasis

BMEMat, EarlyView.
This review introduces the skeletal interoceptive circuitry, covering the ascending signals from bone tissues to the brain (sensors), the central neural circuits that integrate this information and dispatch commands (CPU), and the descending pathways that regulate bone homeostasis (effectors).
Yefeng Wu, Jiusi Guo, Zhen Chen, Fengwei Zhang, Billy Kwok Chong Chow, Zhuofan Chen, Kelvin Wai‐Kwok Yeung, Wei Qiao   +7 more
wiley   +1 more source

A Randomized, Sham‐Controlled Trial of Repetitive Transcranial Magnetic Stimulation Targeting M1 and S2 in Central Poststroke Pain: A Pilot Trial

Neuromodulation: Technology at the Neural Interface, EarlyView., 2021
Abstract Objectives Central poststroke pain (CPSP), a neuropathic pain condition, is difficult to treat. Repetitive transcranial magnetic stimulation (rTMS) targeted to the primary motor cortex (M1) can alleviate the condition, but not all patients respond. We aimed to assess a promising alternative rTMS target, the secondary somatosensory cortex (S2),
Juhani Ojala, Jukka Vanhanen, Hanna Harno, Pantelis Lioumis, Selja Vaalto, Mari A. Kaunisto, Jukka Putaala, Marko Kangasniemi, Erika Kirveskari, Jyrki P. Mäkelä, Eija Kalso   +10 more
wiley   +1 more source