Results 51 to 60 of about 169,368 (383)
Brain Research Bulletin, 2022 Beta band (12–30 Hz) hypersynchrony within the basal ganglia-thalamocortical network has been suggested as a hallmark of Parkinson’s disease (PD) pathophysiology. Abnormal beta band oscillations are found in the pedunculopontine nucleus (PPN) and primary
Xuenan Wang +7 more
doaj +1 more source
A novel DRD2 single-nucleotide polymorphism associated with schizophrenia predicts age of onset: HapMap tag-sincle-nucleotide polymorphism analysis [PDF]
, 2012 Background: Dopamine D2 receptor (DRD2) is thought to be critical in regulating the dopaminergic pathway in the brain which is known to be important in the aetiology of schizophrenia. It is therefore not surprising that most antipsychotic medication acts
Hughes, Ian +5 more
core +2 more sources
Frontiers in Neurology, 2012 Purpose: To assess clinical efficacy of deep brain stimulation of the pallidum in Myoclonus-Dystonia patients, and to compare pre- and postoperative striatal dopamine D2 receptor availability.Methods: Clinical parameters were scored using validated ...
Richard J. Beukers +5 more
doaj +1 more source
Could dopamine agonists aid in drug development for anorexia nervosa? [PDF]
, 2014 Anorexia nervosa is a severe psychiatric disorder most commonly starting during the teenage-years and associated with food refusal and low body weight. Typically there is a loss of menses, intense fear of gaining weight, and an often delusional quality ...
Frank, Guido KW
core +2 more sources
Dopamine D2/3 occupancy of ziprasidone across a day : a within-subject PET study [PDF]
, 2013 Rationale Ziprasidone is an atypical antipsychotic recommended to be administered twice daily. Objectives The purpose of this study was to investigate whether occupancy of the dopamine D2/3 receptors by ziprasidone is maintained across a day ...
Borlido, Carol +10 more
core +1 more source
Relationship of Alexithymia Ratings to Dopamine D2-type Receptors in Anterior Cingulate and Insula of Healthy Control Subjects but Not Methamphetamine-Dependent Individuals. [PDF]
, 2015 BackgroundIndividuals with substance-use disorders exhibit emotional problems, including deficits in emotion recognition and processing, and this class of disorders also has been linked to deficits in dopaminergic markers in the brain.
Ghahremani, Dara G +5 more
core +2 more sources
Dopamine D2-receptor blockade enhances decoding of prefrontal signals in humans. [PDF]
, 2015 The prefrontal cortex houses representations critical for ongoing and future behavior expressed in the form of patterns of neural activity. Dopamine has long been suggested to play a key role in the integrity of such representations, with D2-receptor ...
Haker, Helene +4 more
core +2 more sources
Advanced Materials Technologies, EarlyView.Novel OoC platform with functional vascular networks highlights challenges in oxygenation. This study uses optical oxygen sensors to monitor oxygen during vascular formation, revealing perfusion limitations and highlighting the need for better oxygenation strategies.
Tarek Gensheimer +5 more
wiley +1 more source
Osteocyte-Driven Downregulation of Snail Restrains Effects of Drd2 Inhibitors on Mammary Tumor Cells [PDF]
, 2018 While bone is a frequent target of breast cancer-associated metastasis, little is known about the effects of tumor-bone interactions on the efficacy of tumor-suppressing agents.
Chen, Andy +8 more
core +1 more source
SpaBalance: Balanced Learning for Efficient Spatial Multi‐Omics Decoding
Advanced Science, EarlyView.SpaBalance is a computational framework that harmonizes multi‐omics learning via gradient equilibrium and dual‐stream feature decomposition, achieving superior clustering accuracy, biological interpretability, and scalable integration of three or more spatial omics modalities.
Yingbo Cui +8 more
wiley +1 more source