Results 71 to 80 of about 121,521 (304)

A deep-learning view of chemical space designed to facilitate drug discovery [PDF]

arXiv, 2020
Drug discovery projects entail cycles of design, synthesis, and testing that yield a series of chemically related small molecules whose properties, such as binding affinity to a given target protein, are progressively tailored to a particular drug discovery goal.
arxiv  

From modes to movement in the behavior of C. elegans [PDF]

PLoS ONE 5(11): e13914 (2010), 2009
Organisms move through the world by changing their shape, and here we explore the mapping from shape space to movements in the nematode C. elegans as it crawls on a planar agar surface. We characterize the statistics of the trajectories through the correlation functions of the orientation angular velocity, orientation angle and the mean-squared ...
arxiv   +1 more source

Evidence for Noncanonical Neurotransmitter Activation: Norepinephrine as a Dopamine D2-Like Receptor Agonist

Molecular Pharmacology, 2016
The Gαi/o-coupled dopamine D2-like receptor family comprises three subtypes: the D2 receptor (D2R), with short and long isoform variants (D2SR and D2LR), D3 receptor (D3R), and D4 receptor (D4R), with several polymorphic variants.
Marta Sánchez-Soto, Alessandro Bonifazi, N. Cai, Michael P. Ellenberger, A. Newman, S. Ferré, Hideaki Yano   +6 more
semanticscholar   +1 more source

Analytical and Pharmacological Characterization of 1‐(Furan‐2‐Carbonyl)‐LSD (1F‐LSD) and Comparison With 1‐(Thiophene‐2‐Carbonyl)‐LSD (1T‐LSD)

Drug Testing and Analysis, EarlyView.
The novel lysergamide 1‐(furan‐2‐carbonyl)‐LSD (1F‐LSD) was analytically characterized. 1F‐LSD showed LSD‐like activity in vivo similar to 1‐(thiophene‐2‐carbonyl)‐LSD (1T‐LSD) used for comparison. Administration studies in mice and LC–MS analysis revealed that 1F‐LSD served as a prodrug.
Simon D. Brandt, Pierce V. Kavanagh, Sarah Gare, Simon P. Elliott, Alexander Stratford, Adam L. Halberstadt   +5 more
wiley   +1 more source

Modulation of mechanosensation by endogenous dopaminergic signaling in the lateral parabrachial nucleus in mice

PAIN Reports
. Introduction:. The lateral parabrachial nucleus (LPBN), a crucial hub for integrating and modulating diverse sensory information, is known to express both D1 and D2 dopamine receptors and receive dopaminergic inputs.
Ho Koo, Jigong Wang, Ramesh Pariyar, Regan M. Hammond, Jun-Ho La   +4 more
doaj   +1 more source

Discovery and Characterization of a G Protein–Biased Agonist That Inhibits β-Arrestin Recruitment to the D2 Dopamine Receptor

Molecular Pharmacology, 2014
A high-throughput screening campaign was conducted to interrogate a 380,000+ small-molecule library for novel D2 dopamine receptor modulators using a calcium mobilization assay.
R. Free, L. Chun, Amy E. Moritz, Brittney N. Miller, T. Doyle, Jennie L. Conroy, Adrian Padron, Julie A. Meade, Jingbo Xiao, Xin Hu, Andrés E Dulcey, Yang Han, L. Duan, S. Titus, Melanie Bryant-Genevier, E. Barnaeva, M. Ferrer, J. Javitch, T. Beuming, Lei Shi, Noel Southall, J. Marugan, D. Sibley   +22 more
semanticscholar   +1 more source

Mirtazapine Is Associated With Shorter Hospital Stay in Pediatric Avoidant Restrictive Food Intake Disorder—A Retrospective Chart Review

International Journal of Eating Disorders, EarlyView.
ABSTRACT Objective Avoidant restrictive food intake disorder (ARFID) is a relatively new diagnostic entity, and no medication has been approved. Recent data suggest that mirtazapine, a tetracyclic antidepressant, could improve outcomes in ARFID. We conducted a retrospective chart review to examine the effects of mirtazapine on ARFID treatment in youth.
Aman Chishti, Rachael E. Groh, Tamara R. Maginot, Lisa Adler, Megan E. Shott, Walter H. Kaye, Guido K. W. Frank   +6 more
wiley   +1 more source

Dopamine agonists in Parkinson’s disease: Impact of D1-like or D2-like dopamine receptor subtype selectivity and avenues for future treatment

Clinical Parkinsonism & Related Disorders, 2023
Dopamine agonists (DAs) have demonstrated efficacy for the treatment of Parkinson’s disease (PD) but are limited by adverse effects (AEs). DAs can vary considerably in their receptor subtype selectivity and affinity, chemical composition, receptor ...
Stuart H. Isaacson, Robert A. Hauser, Rajesh Pahwa, David Gray, Sridhar Duvvuri   +4 more
doaj  

Central interaction of ascorbic acid and D2 dopamine receptors on spatial learning and memory in adult male rats [PDF]

The Iranian Journal of Veterinary Science and Technology, 2014
Previous studies had reported that extracellular levels of ascorbic acid have modulatory effects on dopamine receptors. Both ascorbic acid and dopamine receptor have an important role in learning and memory processes.
Sima Nasri, Mehri Bahaaddini, mehdi abbasnejad, Saeed Esmaeili-Mahani, Ramin Raoof   +4 more
doaj   +1 more source

Electronic schematic for bio-plausible dopamine neuromodulation of eSTDP and iSTDP [PDF]

arXiv, 2018
In this technical report we present novel results of the dopamine bio-plausible neuromodulation excitatory (eSTDP) and inhibitory (iSTDP) learning. We present the principal schematic for the neuromodulation of D1 and D2 receptors of dopamine, wiring schematic for both cases as well as the simulatory experiments results done in LTSpice.
arxiv