Results 71 to 80 of about 48,073 (302)

Safety and Effect of 12‐Month Ecopipam Treatment in Pediatric Patients with Tourette Syndrome

Movement Disorders Clinical Practice, EarlyView.
Abstract Background Tourette syndrome (TS) is a chronic neurodevelopmental tic disorder with a considerable quality of life (QOL) burden. Objectives The goal was to determine the long‐term safety, tolerability, and clinical effects of ecopipam, a first‐in‐class dopamine D1 receptor antagonist, for TS.
Donald L. Gilbert, David J.B. Kim, Meredith M. Miller, Sarah D. Atkinson, George B. Karkanias, Frederick E. Munschauer, Stephen P. Wanaski, Timothy M. Cunniff   +7 more
wiley   +1 more source

CHL1 depletion affects dopamine receptor D2-dependent modulation of mouse behavior. [PDF]

Front Behav Neurosci, 2023
Fernandes L, Kleene R, Congiu L, Freitag S, Kneussel M, Loers G, Schachner M.   +6 more
europepmc   +1 more source

Gender Is the Main Predictor of Wearing‐Off and Dyskinesia in Levodopa‐Naïve Patients with Parkinson's Disease

Movement Disorders Clinical Practice, EarlyView.
Abstract Background Evidence suggests that female gender represents a risk factor for the development of motor/nonmotor fluctuations and dyskinesia in Parkinson's disease (PD). So far, no prospective study has analyzed this aspect in relation to the introduction of levodopa treatment.
Maria Teresa Pellecchia, Marina Picillo, Maria Claudia Russillo, Marianna Amboni, Gennarina Arabia, Laura Avanzino, Margherita Canesi, Alessia Catania, Roberto Ceravolo, Calogero Edoardo Cicero, Roberto Cilia, Isabel Colangelo, Giovanna Dati, Rosa De Micco, Anna De Rosa, Alessio Di Fonzo, Roberto Eleopra, Vincenza Fetoni, Barbara Garavaglia, Augusta Giglio, Martina Giuntini, Federica Invernizzi, Giulia Lazzeri, Roberta Marchese, Alessandra Nicoletti, Claudio Pacchetti, Celeste Panteghini, Manuela Pilleri, Fabiana Radicati, Chiara Reale, Cesa Scaglione, Andrea Soricelli, Fabrizio Stocchi, Alessandro Tessitore, Laura Vacca, Maria Antonietta Volontè, Graziella Volpi, Roberta Zangaglia, Francesco Amato, Carlo Ricciardi, Michela Russo, Paolo Barone   +41 more
wiley   +1 more source

Dopamine D2 antagonist-induced striatal Nur77 expression requires activation of mGlu5 receptors by cortical afferents

Frontiers in Pharmacology, 2012
Dopamine D2 receptor antagonists modulate gene transcription in the striatum. However, the molecular mechanism underlying this effect remains elusive. Here we used the expression of Nur77, a transcription factor of the orphan nuclear receptor family, as ...
Jérôme eMaheux, Michel eSt-Hilaire, David eVoyer, Emanuele eTirotta, Emiliana eBorrelli, Claude eRouillard, Pierre-Paul eRompré, Daniel eLévesque   +7 more
doaj   +1 more source

Management of Anxiety in Parkinson's Disease

Movement Disorders Clinical Practice, EarlyView.
ABSTRACT Background Anxiety is a common, distressing, hard‐to‐diagnose and hard‐to‐treat symptom in Parkinson's disease. No formal guidelines exist to assist management. Objective We provide a pragmatic guide to detecting and managing anxiety in Parkinson's disease.
Alex J. Berry, Harry Costello, Silvia Jesús, Gary Price, Ashwani Jha   +4 more
wiley   +1 more source

A novel dopamine receptor D2 antagonist (ONC206) potentiates the effects of olaparib in endometrial cancer. [PDF]

Cancer Biol Ther, 2023
Paraghamian SE, Qiu J, Hawkins GM, Zhao Z, Sun W, Fan Y, Zhang X, Suo H, Hao T, Prabhu VV, Allen JE, Zhou C, Bae-Jump V.   +12 more
europepmc   +1 more source

Cholinergic System Changes in Dopa‐Unresponsive Freezing of Gait in Parkinson's Disease

Movement Disorders, EarlyView.
Abstract Background Freezing of gait (FoG) is a debilitating mobility disturbance that becomes increasingly resistant to dopaminergic pharmacotherapies with advancing Parkinson's disease (PD). The pathophysiology underlying the response of FoG to dopaminergic treatment is poorly understood.
Kelvin L. Chou, Prabesh Kanel, Miriam van Emde Boas, Stiven Roytman, Giulia Carli, Roger L. Albin, Nicolaas I. Bohnen   +6 more
wiley   +1 more source

The dopamine D1 receptor is expressed and induces CREB phosphorylation and MUC5AC expression in human airway epithelium

Respiratory Research, 2018
Background Dopamine receptors comprise two subgroups, Gs protein-coupled “D1-like” receptors (D1, D5) and Gi-coupled “D2-like” receptors (D2, D3, D4). In airways, both dopamine D1 and D2 receptors are expressed on airway smooth muscle and regulate airway
Nao Matsuyama, Sumire Shibata, Atsuko Matoba, Tada-aki Kudo, Jennifer Danielsson, Atsushi Kohjitani, Eiji Masaki, Charles W. Emala, Kentaro Mizuta   +8 more
doaj   +1 more source

Effect of risperidone on morphine-induced conditioned place preference and dopamine receptor D2 gene expression in male rat hippocampus. [PDF]

Brain Behav, 2023
Arani ZM, Heidariyeh N, Ghavipanjeh G, Lotfinia M, Banafshe HR.   +4 more
europepmc   +1 more source

Direct visualization and cellular localization of D1 and D2 dopamine receptors in rat forebrain by use of fluorescent ligands. [PDF]

, 1989
Marjorie A. Ariano, Frederick J. Monsma, Anne Barton, Hoon‐Chul Kang, R P Haugland, David R. Sibley   +5 more
openalex   +1 more source