Results 71 to 80 of about 169,368 (383)
Pergolide Mesilate May Improve Fatigue in Patients with Parkinson’s Disease
Behavioural Neurology, 2002 Objectives: Fatigue is a complaint frequently encountered among patients with Parkinson’s disease (PD). Considering the possible relationship between fatigue and dopaminergic dysfuncion, we investigated the effect of pergolide mesilate (a D2 and D1 ...
Kazuo Abe +3 more
doaj +1 more source
Activation of D2 dopamine receptor-expressing neurons in the nucleus accumbens increases motivation
Nature Communications, 2016 Striatal dopamine receptor D1-expressing neurons have been classically associated with positive reinforcement and reward, whereas D2 neurons are associated with negative reinforcement and aversion. Here we demonstrate that the pattern of activation of D1
C. Soares-Cunha +7 more
semanticscholar +1 more source
Autism Research, EarlyView.ABSTRACT Recent studies have implicated oxidative stress in the pathophysiology of autism spectrum disorder (ASD). Postmortem brain studies have revealed decreased levels of the reduced form of glutathione (GSH), an important antioxidant, in some brain regions in individuals with ASD; however, in vivo evidence is lacking.
Toshiki Iwabuchi +10 more
wiley +1 more source
BMC Neuroscience, 2007 Background In both schizophrenia and addiction, pathological changes in dopamine release appear to induce alterations in the circuitry of the nucleus accumbens that affect coordinated thought and motivation. Dopamine acts principally on medium-spiny GABA
Schmauss Claudia +2 more
doaj +1 more source
Central dopamine D2 receptors regulate plasma glucose levels in mice through autonomic nerves
Scientific Reports, 2020 Recent evidence suggests that the central nervous system (CNS) regulates plasma glucose levels, but the underlying mechanism is unclear. The present study investigated the role of dopaminergic function in the CNS in regulation of plasma glucose levels in
Hiroko Ikeda +8 more
doaj +1 more source
Distinct patterns of outcome valuation and amygdala-prefrontal cortex synaptic remodeling in adolescence and adulthood. [PDF]
, 2015 Adolescent behavior is typified by increased risk-taking, reward- and novelty-seeking, as well as an augmented need for social and environmental stimulation.
Izquierdo, Alicia, Stolyarova, Alexandra
core +2 more sources
European Archives of Psychiatry and Clinical Neuroscience, 2016 R-ketamine appears to be a potent, long-lasting and safer antidepressant, relative to esketamine (S-ketamine), since it might be free of psychotomimetic side effects.
K. Hashimoto +4 more
semanticscholar +1 more source
Typical Applications and Flame‐Retardant Strategies for Organic Phase‐Change Materials
Carbon Energy, EarlyView.ABSTRACT This study begins by exploring the typical practical applications of phase‐change materials (PCMs) in various industries, highlighting their importance in energy storage, temperature regulation, and thermal management. It then emphasizes the necessity of flame‐retardant functionalization tailored to the specific application scenarios of PCMs ...
Xiao‐Mei Yang +5 more
wiley +1 more source
Modulation of Adenylyl Cyclase Activity in Rat Striatal Homogenate by Dopaminergic Receptors
Journal of Pharmacological Sciences, 2008 We have characterized the modulation of adenylyl cyclase (AC) activity by ligands of dopaminergic receptors in rat striatal homogenate and compared the results with receptor-ligand binding affinities.
Argo Vonk, Reet Reinart, Ago Rinken
doaj +1 more source
A molecular basis for selective antagonist destabilization of dopamine D3 receptor quaternary organization [PDF]
, 2017 The dopamine D3 receptor (D3R) is a molecular target for both first-generation and several recently-developed antipsychotic agents. Following stable expression of this mEGFP-tagged receptor, Spatial Intensity Distribution Analysis indicated that a ...
Caltabiano, Gianluigi +6 more
core +2 more sources