Results 121 to 130 of about 265,775 (287)

Activation of 5-HT 2A Receptor Disrupts Rat Maternal Behavior [PDF]

, 2019
Serotonin 5-HT2A receptor is widely distributed in the central nervous system and plays an important role in sensorimotor function, emotion regulation, motivation, executive control, learning and memory. We investigated its role in rat maternal behavior,
Davis, Collin, Gao, Jun, Li, Ming, Wu, Ruiyong   +3 more
core   +1 more source

Engineering Osteoimmune Responses with Functionalized Orthopedic Implants for Post‐Operative Osteosarcoma Treatment

Advanced Science, EarlyView.
Osteosarcoma is the most common primary bone tumor with limited treatment options and a terrible prognosis. This review provides a comprehensive summary of the recent development of osteoimmunomodulatory implants for post‐operative osteosarcoma treatment, of which the potential utility in evoking durable anti‐osteosarcoma immunity and accelerating bone
Yilong Dong, Lingshuang Wang, Hui Zhang, Menghuan Li, Zhong Luo, Yan Hu, Chunyuan Cai   +6 more
wiley   +1 more source

Evidence for a Stereoselective Mechanism for Bitopic Activity by Extended-Length Antagonists of the D₃ Dopamine Receptor

, 2020
Amy E. Moritz, Alessandro Bonifazi, Adrian M. Guerrero, Vivek Kumar, R. Benjamin Free, J. Robert Lane, Ravi Kumar Verma, Lei Shi, Amy Hauck Newman, David R. Sibley   +9 more
openalex   +2 more sources

Depotentiation in the Dentate Gyrus of Freely Moving Rats is Modulated by D1/D5 Dopamine Receptors [PDF]

, 2000
Alexander Kulla
openalex   +1 more source

The Gut Microbiota Regulates Motor Deficits via Butyrate in a Gnal+/− Mouse Model of DYT25 Dystonia

Advanced Science, EarlyView.
The present study provides compelling evidence for a modulatory role of the gut microbiota in the pathology of DYT25 dystonia, and butyrate supplementation alleviates the motor deficits of dystonia in Gnal+/− mice. Abstract Dystonia is the third most common movement disorder, following essential tremor and Parkinson's disease. The underlying mechanisms
Jingya Guo, Seong‐Gook Kang, Kunlun Huang, Tao Tong   +3 more
wiley   +1 more source

Effect of Dopamine D₂ Receptor Antagonists on [¹⁸F]-FEOBV Binding

, 2020
Anna Schildt, Erik F. J. de Vries, Antoon T. M. Willemsen, Bruno Lima Giacobbo, Rodrigo Moraga‐Amaro, Jürgen W. A. Sijbesma, Aren van Waarde, Vesna Sossi, Rudi Dierckx, Janine Doorduin   +9 more
openalex   +1 more source

The role of the dopamine D1 receptor in social cognition: studies using a novel genetic rat model [PDF]

, 2016
Judith R. Homberg, Berend Olivier, M. VandenBroeke, Jiun Youn, A. K. Ellenbroek, Peter Karel, Ling Shan, Ruben van Boxtel, Sharon Ooms, M. Balemans, Jacqueline Langedijk, Maria Müller, Gert Vriend, A.R. Cools, Edwin Cuppen, Bart Ellenbroek   +15 more
openalex   +1 more source

A Local Circuit Model of Learned Striatal and Dopamine Cell Responses under Probabilistic Schedules of Reward [PDF]

, 2007
Before choosing, it helps to know both the expected value signaled by a predictive cue and the associated uncertainty that the reward will be forthcoming. Recently, Fiorillo et al.
Bullock, Daniel, Tan, Can Ozan
core   +1 more source

Flipping the Switch: MeCP2‐Mediated Lactylation Rewires Microglial Metabolism and Inflammation via the HK2/mTOR Axis in Poststroke Neuroinflammation

Advanced Science, EarlyView.
Stroke‐induced lactate accumulation promotes p300‐mediated lactylation of methyl‐CpG binding protein 2 (MeCP2) at lysine 210, which reprograms microglial metabolism toward glycolysis and activates the hexokinase 2 (HK2)/mTOR axis. This cascade promotes proinflammatory responses and impairs neurofunctional outcomes.
Zengyu Zhang, Shanshan Huang, Yong Wang, Zhiwen Jiang, Zhuohang Liu, Chenran Wang, Rong Ji, Yiwen Yuan, Xueyu Mao, Kaicheng Yang, Huicong Niu, Yanqin Gao, Jing Zhao   +12 more
wiley   +1 more source

1614: Dopamine Dl Receptor Agonist-Induced Erections in Awake and Freely Moving Rats [PDF]

, 2004
Kenshi Matsumoto, Karl‐Erik Andersson, Petter Hedlund   +2 more
openalex   +1 more source