Results 171 to 180 of about 240,256 (373)

Somatic cell reprogramming for Parkinson's disease treatment

open access: yesIbrain, Volume 11, Issue 1, Page 59-73, Spring 2025.
The fundamental purpose of cell reprogramming to treat Parkinson's disease is to generate dopaminergic neurons (DAN) and do transplantation. There are two ways to accomplish this. One method is to induce cells into induced DA neurons (iDAN) directly or to induce cells into induced pluripotent stem cells and ultimately into iDAN in vitro. Another option
Xiaozhuo Li, Kevin Fang, Fengping Wang
wiley   +1 more source

Prefrontal cortex iron content in neurodegeneration and healthy subjects: A systematic review

open access: yesIbrain, EarlyView.
This systematic review summarizes magnetic resonance imaging (MRI)‐based assessments of prefrontal cortex (PFC) iron accumulation in healthy individuals and patients with neurodegenerative diseases. The review includes 12 studies using techniques such as susceptibility‐weighted imaging (SWI), quantitative susceptibility mapping (QSM), and R2* mapping ...
Sana Mohammadi   +3 more
wiley   +1 more source

Immunomodulatory natural polysaccharide‐based nanoparticles for the treatment of neurodegenerative diseases

open access: yesIbrain, EarlyView.
Polysaccharide‐based nanoparticles offer versatile platforms for drug delivery and immune modulation in neurodegenerative diseases. This review highlights their potential in treating Alzheimer's, Parkinson's, and multiple sclerosis, focusing on targeted delivery and neuroinflammation.
Leto‐Aikaterini Tziveleka   +5 more
wiley   +1 more source

The potential role of environmentally associated DNA methylation in childhood acute lymphoblastic leukaemia subtypes

open access: yesInternational Journal of Cancer, EarlyView.
What's New? The rarity of acute lymphoblastic leukaemia and lack of available environmental data have made the role of environmental factors in genetic subtypes challenging to investigate. Here, the authors performed a CpG‐level analysis to investigate DNA methylation as an intermediate mechanism between environmental risk exposures and acute ...
Jessica R. Saville   +5 more
wiley   +1 more source

Recent Advancements in Microfluidic Biosensors for Clinical Applications

open access: yesiLABMED, EarlyView.
The combination of low‐consumption microfluidic chips and high‐sensitivity biosensors enables rapid and accurate detection of complex target analytes. This integrated system holds significant potential for applications in disease diagnosis, health monitoring, and treatment management.
Haiyan Wang, Wenjuan Wu
wiley   +1 more source

Continuous Dopaminergic Stimulation in Parkinson's Disease [PDF]

open access: bronze, 1987
José Á. Obeso   +4 more
openalex   +1 more source

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