Results 211 to 220 of about 160,871 (266)
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Future directions in dopaminergic nervous system and dopaminergic agonists
Journal of Medicinal Chemistry, 1981The physiological and pharmacological roles of pre- and postsynaptic dopamine receptors in modification of neuronal transmission centrally and peripherally will be subjects for intense research during the next decade. As enumerated by Langer, dopamine-sensitive receptors have been described that may inhibit or facilitate release of neurotransmitter ...
J G, Cannon, J P, Long, R, Bhatnagar
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Complications of Dopaminergic Therapy
Disease-a-Month, 2007both of which can be very difficult to manage. 1-3 The delayed use of l-dopa and then when necessary using the minimal amount of l-dopa required to treat symptoms is now an accepted strategy in the management of Parkinson’s disease. This strategy can minimize and/or forestall the development of the troublesome complications of dopaminergic therapy.
Amy, Kessler, Michael, Rezak
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A dopaminergic mechanism in mania
American Journal of Psychiatry, 1976The authors present a case study that explores the relationship of dopamine function and manic illness through the use of two drugs with relatively specific effects in stimulating and blocking dopamine receptors--piribedil (ET--495) and pimozide, respectively.
R H, Gerner, R M, Post, W E, Bunney
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Is there a ?dopaminergic glial cell??
Neurochemical Research, 1984Intracellular cAMP increased 9-fold in cerebral hemisphere primary cultures after incubation with dopamine (10(-4) M). The effect was dose- and time-dependent (10(-6) M-10(-4) M; 2-10 minutes). It was mimicked, to some extent, by the partial agonist apomorphine (10(-5) M-10(-4) M) and antagonized by fluphenazine (10(-5) M-10(-4) M).
E, Hansson, L, Rönnbäck, A, Sellström
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Dopaminergic defect in hypertension
Pediatric Nephrology, 1993Reverse genetics and the candidate gene approach have been utilized to identify the genetic defect(s) in hypertension. We have proposed the dopamine receptor gene as one candidate in the pathogenesis of hypertension. Because some forms of hypertension are sodium dependent or aggravated by sodium loading and because dopamine is important in aiding the ...
P A, Jose, G M, Eisner, R A, Felder
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Dopaminergic activity of quipazine
Pharmacology Biochemistry and Behavior, 1982Rats were trained to discriminate between the stimulus properties of intraperitoneal 0.16 mg/kg apomorphine and saline in a two-lever, food-motivated operant task. Administration of 1.0 mg/kg quipazine, a putative serotonin agonist, produced apomorphine-appropriate responding with a maximal effect occurring at 45 min post-injection.
M D, Schechter, J T, Concannon
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Dopaminergic properties of nomifensine
Pharmacology Biochemistry and Behavior, 1982Nomifensine and a proposed dihydroxy metabolite produced stimulation of motor behavior in mice with nomifensine being more potent. Weak cage-climbing behavior (stereotypy) was also produced. The stimulatory effects were greater in mice in which dopamine receptor sensitivity was increased by long-term haloperidol.
G, Gianutsos +3 more
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Flavonoids as dopaminergic neuromodulators
Molecular Nutrition & Food Research, 2016ScopeThe present study aimed to characterize and evaluate flavonoids effects on organic cation uptake in neuronal cells.Methods and resultsUptake experiments were conducted using radiolabeled methyl‐4‐phenylpyridinuim ([3H]‐MPP+), in human neuronal dopaminergic cells, SH‐SY5Y.
Meireles, M. +8 more
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Ethanol and dopaminergic systems
Pharmacology Biochemistry and Behavior, 1983Chronic ethanol consumption produces derangements of cell membrane structure, perhaps by changing membrane lipid content. This impairment leads to modification of membrane-related processes. In fact, after chronic ethanol exposure, an increase in striatal adenylate-cyclase activity occurs. On the other hand, dopamine is unable to further potentiate the
Lucchi L +5 more
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Nature, 1978
THE clinical treatment of parkinsonism with the dopamine (DA) precursor L-dopa has certain drawbacks1 and there are relatively few drugs which directly stimulate DA receptors (although there are many which block them, such as the neuroleptics). There is thus great industrial, academic and clinical interest in the development of new DA-receptor ...
A S, Horn +7 more
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THE clinical treatment of parkinsonism with the dopamine (DA) precursor L-dopa has certain drawbacks1 and there are relatively few drugs which directly stimulate DA receptors (although there are many which block them, such as the neuroleptics). There is thus great industrial, academic and clinical interest in the development of new DA-receptor ...
A S, Horn +7 more
openaire +3 more sources