Results 231 to 240 of about 240,256 (373)

Safety and Effect of 12‐Month Ecopipam Treatment in Pediatric Patients with Tourette Syndrome

Movement Disorders Clinical Practice, EarlyView.
Abstract Background Tourette syndrome (TS) is a chronic neurodevelopmental tic disorder with a considerable quality of life (QOL) burden. Objectives The goal was to determine the long‐term safety, tolerability, and clinical effects of ecopipam, a first‐in‐class dopamine D1 receptor antagonist, for TS.
Donald L. Gilbert, David J.B. Kim, Meredith M. Miller, Sarah D. Atkinson, George B. Karkanias, Frederick E. Munschauer, Stephen P. Wanaski, Timothy M. Cunniff   +7 more
wiley   +1 more source

α2-Adrenergic Receptors in Hypothalamic Dopaminergic Neurons: Impact on Food Intake and Energy Expenditure. [PDF]

Int J Mol Sci
Park BS, Yang HR, Kang H, Kim KK, Kim YT, Yang S, Kim JG.   +6 more
europepmc   +1 more source

Dopaminergic neurotoxins, MPTP and MPP+, inhibit activity of mitochondrial NADH-ubiquinone oxidoreductase.

, 1986
Yoshikuni Mizuno, Nobuhito Sone, Tomohiko Saitoh   +2 more
openalex   +2 more sources

Speech Differences between Multiple System Atrophy and Parkinson's Disease

Movement Disorders Clinical Practice, EarlyView.
Abstract Background Delineation of Parkinson's disease (PD) from multiple system atrophy (MSA) can be challenging in early disease stages. Speech characteristics have been studied as digital biomarkers in PD and ataxias. Currently, data on speech in MSA is limited.
Tom Hähnel, Anna Nemitz, Katja Schön, Luise Berger, Annemarie Vogel, Doreen Gruber, Nils Schnalke, Stefan Bräuer, Björn H. Falkenburger, Florin Gandor   +9 more
wiley   +1 more source

The Virtual Parkinsonian patient. [PDF]

NPJ Syst Biol Appl
Angiolelli M, Depannemaecker D, Agouram H, Régis J, Carron R, Woodman M, Chiodo L, Triebkorn P, Ziaeemehr A, Hashemi M, Eusebio A, Jirsa V, Sorrentino P.   +12 more
europepmc   +1 more source

Investigating Dopamine Replacement–Associated Fluctuations in Cognition and Mood in Cognitively Unimpaired Parkinson's Disease

Movement Disorders Clinical Practice, EarlyView.
Abstract Background Non‐motor fluctuations, characterized by variability in mood and cognition, are prevalent in advanced Parkinson's disease (PD), but less is known about these fluctuations in early PD. Objective The objective was to characterize fluctuations in cognition and mood in early PD without cognitive impairment.
Abhimanyu Mahajan, Christopher B. Morrow, Joseph Seemiller, Kelly A. Mills, Gregory M. Pontone   +4 more
wiley   +1 more source

Herbal Interventions in Parkinson's Disease: A Systematic Review of Preclinical Studies. [PDF]

Cell Mol Neurobiol
Zhao W, Cui H, Liu J, Sun H, Zhang Z, Zhang Z, Ma D.   +6 more
europepmc   +1 more source

Myoclonic Dystonia: A Common Phenomenology in the Pleomorphic Movements of Angelman Syndrome

Movement Disorders Clinical Practice, EarlyView.
Abstract Background Angelman syndrome (AS) is a neurodevelopmental disorder characterized by developmental delay, intellectual disability, a sociable demeanor, and abnormal movements. People with AS often exhibit multiple types of abnormal movements, including nonepileptic myoclonus, tremor, and dystonia, which hamper attempts to identify phenomenology
Robert P. Carson, Heather Riordan, Brittany Short, Thomas Davis, John Fang, Andrew Giritharan, David A. Isaacs, Joanna Blackburn, Bhooma Aravamuthan   +8 more
wiley   +1 more source

Artemisiae Iwayomogii Herba Protects Dopaminergic Neurons Against 1-Methyl-4-phenylpyridinium/1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine Neurotoxicity in Models of Parkinson's Disease. [PDF]

Nutrients
Lee H, Ju IG, Kim JH, Choi Y, Lee S, Park HJ, Oh MS.   +6 more
europepmc   +1 more source

Functional Connectivity and Volumetrics Improve Outcome Prediction for Deep Brain Stimulation in Parkinson's Disease

Movement Disorders Clinical Practice, EarlyView.
Abstract Background Deep brain stimulation (DBS) targeting the subthalamic nucleus (STN) can effectively treat motor symptoms of Parkinson's disease (PD). However, optimal patient selection remains challenging due to the inadequacy of outcome predictors.
John R. Younce, Scott A. Norris, Mwiza Ushe, Joel S. Perlmutter   +3 more
wiley   +1 more source