Results 231 to 240 of about 297,910 (307)

Uncovering the Complexity of Synucleinopathies: An Ongoing Tale Between Proteins and Lipids

Movement Disorders, EarlyView.
Abstract Neurodegenerative diseases are pathological states characterized by progressive alterations in brain homeostasis during aging. Synucleinopathies, including Parkinson's disease and dementia with Lewy bodies, are defined neuropathologically by the accumulation of inclusions known as Lewy bodies and Lewy neurites.
Manuel Flores‐León, Tiago F. Outeiro
wiley   +1 more source

The Race to Salvage Glucocerebrosidase: Understanding Small‐Molecule Therapies for GBA1‐Associated Parkinsonism

Movement Disorders, EarlyView.
Variants in GBA1, the gene encoding the lysosomal enzyme glucocerebrosidase, cause Gaucher disease and confer an increased risk for parkinsonism. Strategies using small molecules can improve the function of glucocerebrosidase in lysosomes. A clear understanding of the mechanism‐of‐action of these compounds will facilitate development of GBA1‐modulating
Mark J. Henderson, Tiffany C. Chen, Logan M. Glasstetter, Yu Chen, Juan J. Marugan, Ellen Sidransky   +5 more
wiley   +1 more source

An in vivo and in vitro spatiotemporal profile of human midbrain development. [PDF]

Nat Commun
Budinger D, Puigdevall P, Hall GT, Roth C, Xenakis T, Marrosu E, Jerber J, Di Domenico A, Picco F, Kilpinen H, Castellano S, Kurian MA, Barral S.   +12 more
europepmc   +1 more source

POLG‐Related Parkinsonism with Good Response to Deep Brain Stimulation

Movement Disorders Clinical Practice, EarlyView.
Evdokia Efthymiou, Fabian Büchele, Sujitha Mahendran, Lennart Stieglitz, Bettina Balint   +4 more
wiley   +1 more source

Parkinson's Disease Patient‐Specific Striatum Organoids Show Hallmarks of Increased Inflammation

Movement Disorders, EarlyView.
Abstract Background Dopaminergic neurons from the substantia nigra pars compacta project their axons into the dorsal striatum, forming the nigrostriatal pathway. In Parkinson's disease (PD), dopaminergic terminals degenerate in the striatum, leading to dopamine depletion, which in turn causes alterations in the basal ganglia circuits that are essential
Kyriaki Barmpa, Claudia Saraiva, Alise Zagare, Mona Tuzza, Joseph Longworth, Elisa Zuccoli, Katrin Hufnagel, Florian Skwirblies, Ronny Schmidt, Dirk Brenner, Christoph Schröder, Jens C. Schwamborn   +11 more
wiley   +1 more source

Erratum: Mating status-dependent dopaminergic modulation of auditory sensory neurons in <i>Drosophila</i>. [PDF]

iScience
Yamakoshi H, Horigome M, Yamamoto S, Iwanami S, Iwami S, Tanaka R, Ishikawa Y, Kamikouchi A.   +7 more
europepmc   +1 more source

Protection Against Cellular Toxicity from Rotenone Treatment by the Neuroprotective, Novel Multifunctional Antiparkinsonian Drug D-512. [PDF]

J Pers Med
Ravipati P, Xu L, Yedlapudi D, Dutta AK.
europepmc   +1 more source

Microengineering of the capillary interface of midbrain dopaminergic neurons to study Parkinson's disease vascular alterations. [PDF]

Commun Eng
Alim A, Baek Y, Lee M, Paek J.
europepmc   +1 more source

Reduced striatal dopamine transmission as a transdiagnostic substrate of psychomotor retardation. [PDF]

Brain
Leong IL, Ng TH, Sen K, Burchill E, Costello H, Badenoch JB, Coebergh J, McCutcheon RA, Nair A, Browning M, Huys QJM, Lewis G, Lees A, David AS, Rogers JP.   +14 more
europepmc   +1 more source