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Ethanol and dopaminergic systems
Pharmacology Biochemistry and Behavior, 1983Chronic ethanol consumption produces derangements of cell membrane structure, perhaps by changing membrane lipid content. This impairment leads to modification of membrane-related processes. In fact, after chronic ethanol exposure, an increase in striatal adenylate-cyclase activity occurs. On the other hand, dopamine is unable to further potentiate the
Lucchi L +5 more
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A Diet for Dopaminergic Neurons?
2009Parkinson's disease (PD) is the second most common neurodegenerative disease, which unfortunately is still fatal. Since the discovery of dopamine (DA) neuronal cell loss within the substantia nigra in PD, the past decades have seen the understanding of the pathophysiological mechanisms underlying the degenerative process advance at a very impressive ...
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The International Journal of Biochemistry & Cell Biology, 2005
Dopaminergic neurons of the midbrain are the main source of dopamine (DA) in the mammalian central nervous system. Their loss is associated with one of the most prominent human neurological disorders, Parkinson's disease (PD). Dopaminergic neurons are found in a 'harsh' region of the brain, the substantia nigra pars compacta, which is DA-rich and ...
Julie K. Andersen, Shankar J. Chinta
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Dopaminergic neurons of the midbrain are the main source of dopamine (DA) in the mammalian central nervous system. Their loss is associated with one of the most prominent human neurological disorders, Parkinson's disease (PD). Dopaminergic neurons are found in a 'harsh' region of the brain, the substantia nigra pars compacta, which is DA-rich and ...
Julie K. Andersen, Shankar J. Chinta
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The dopaminergic amacrine cell
Journal of Comparative Neurology, 1990AbstractThe detailed morphology of the dopaminergic amacrine cell type has been characterized in the macaque monkey retina by intracellular injection of horseradish peroxidase (HRP). This cell type was recognized by its large soma in an in vitro, wholemount preparation of the retina stained with the fluorescent dye, acridine orange.
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Journal of Neural Transmission, 1980
Bromocriptine reduces the spontaneous firing rate of neurons in the pars compacta of the substantia nigra but does not change the electrical activity of the neurons located in the pars reticulata. On the other hand, bromocriptine induces contralateral circling behaviour in rats with unilateral 6-hydroxydopamine nigral lesion.
SCARNATI, Eugenio +4 more
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Bromocriptine reduces the spontaneous firing rate of neurons in the pars compacta of the substantia nigra but does not change the electrical activity of the neurons located in the pars reticulata. On the other hand, bromocriptine induces contralateral circling behaviour in rats with unilateral 6-hydroxydopamine nigral lesion.
SCARNATI, Eugenio +4 more
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The organization of dopaminergic and non-dopaminergic mesencephalo-cortical neurons in the rat
Brain Research, 1982The dopamine containing mesencephalo-cortical pathway was studied in the rat by means of a combined retrograde fluorescent tracing and catecholamine histofluorescence technique. After large injections of the fluorescent retrograde tracer, Evans blue, into the frontal cortex, many neural somata of the ventral midbrain tegmentum were retrogradely labeled;
Albanese, Alberto, Bentivoglio, M.
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Peripheral dopaminergic nerves
Pharmacology & Therapeutics, 1989The concept that dopamine (DA) might have a parallel role as a neurotransmitter in the peripheral nervous system has an even shorter history, but recent research, especially since the advent of immunohistochemical techniques, has provided a wide spectrum of supportive evidence.
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Dopaminergic mechanisms in hemiparkinsonian monkeys
Neurology, 1987The motor effects of direct agonists which act selectively on certain dopamine receptors were studied in monkeys rendered hemiparkinsonian by unilateral intracarotid injection of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP). The D-2 dopamine agonist, LY 171555, but not the D-1 agonist, SKF 38393, reduced parkinsonian signs and induced rotation ...
BARONE P +4 more
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Dopaminergic neurons for Parkinson's therapy [PDF]
Nature Biotechnology, 2012 A differentiation protocol guided by developmental principles produces more-authentic dopaminergic neurons for transplantation in patients.
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Psychiatric Clinics of North America, 1997
This article describes D1 and D2 receptor subfamilies, their neuroanatomic localizations and the possibility of their neuronal co-localization and relation to the other dopamine autoreceptors and those coupled to G-proteins as well as the actions of antipsychotic drugs on D1 and D2 receptor subfamilies are also analyzed.
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This article describes D1 and D2 receptor subfamilies, their neuroanatomic localizations and the possibility of their neuronal co-localization and relation to the other dopamine autoreceptors and those coupled to G-proteins as well as the actions of antipsychotic drugs on D1 and D2 receptor subfamilies are also analyzed.
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