Results 281 to 290 of about 402,660 (356)

Early Cervical and Orofacial Variable Dystonia in Levodopa‐Naïve PRKN Parkinson's Disease

Movement Disorders Clinical Practice, EarlyView.
Amy Gallagher, Aine Redmond, John McKinley, John Inocentes, Diana A Olszewska, Conor Fearon, Tim Lynch   +6 more
wiley   +1 more source

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Therapeutic strategies for Parkinson disease: beyond dopaminergic drugs

Nature Reviews Drug Discovery, 2018
Delphine Charvin, Robert A Hauser, Olivier Rascol   +2 more
exaly   +2 more sources

Small molecule inhibits α-synuclein aggregation, disrupts amyloid fibrils, and prevents degeneration of dopaminergic neurons

Proceedings of the National Academy of Sciences of the United States of America, 2018
Significance Parkinson’s disease is characterized by the accumulation of amyloid deposits in dopaminergic neurons, mainly composed of the protein α-synuclein.
Jordi Pujols, Samuel Pena-Diaz, Diana F Lazaro   +2 more
exaly   +2 more sources

Dopaminergic neurons

The International Journal of Biochemistry & Cell Biology, 2005
Dopaminergic neurons of the midbrain are the main source of dopamine (DA) in the mammalian central nervous system. Their loss is associated with one of the most prominent human neurological disorders, Parkinson's disease (PD). Dopaminergic neurons are found in a 'harsh' region of the brain, the substantia nigra pars compacta, which is DA-rich and ...
Shankar J, Chinta, Julie K, Andersen
openaire   +2 more sources

Dopaminergic and non-dopaminergic circling activity of mice

Neuroscience, 1979
Abstract Male ICR albino mice kept in a closed space tend to rotate and have a preferred direction of rotation, which is more often to the left (65%) than to the right (35%). This circling asymmetry was measured with a rotometer in a group of animals following administration of various drugs.
A D, Korczyn, Y, Eshel
openaire   +2 more sources

Future directions in dopaminergic nervous system and dopaminergic agonists

Journal of Medicinal Chemistry, 1981
The physiological and pharmacological roles of pre- and postsynaptic dopamine receptors in modification of neuronal transmission centrally and peripherally will be subjects for intense research during the next decade. As enumerated by Langer, dopamine-sensitive receptors have been described that may inhibit or facilitate release of neurotransmitter ...
J G, Cannon, J P, Long, R, Bhatnagar
openaire   +2 more sources

Complications of Dopaminergic Therapy

Disease-a-Month, 2007
both of which can be very difficult to manage. 1-3 The delayed use of l-dopa and then when necessary using the minimal amount of l-dopa required to treat symptoms is now an accepted strategy in the management of Parkinson’s disease. This strategy can minimize and/or forestall the development of the troublesome complications of dopaminergic therapy.
Amy, Kessler, Michael, Rezak
openaire   +2 more sources