Results 51 to 60 of about 398,911 (393)

The BE (2)-M17 cell line has a better dopaminergic phenotype than the traditionally used for Parkinson´s research SH-SY5Y, which is mostly serotonergic

IBRO Neuroscience Reports, 2022
SH-SY5Y is a cell line derived from human neuroblastoma. It is one of the most widely used in vitro models to study Parkinson’s disease. Surprisingly, it has been found that it does not develop a dopaminergic phenotype after differentiation, questioning ...
Angel Carvajal-Oliveros, Maritere Uriostegui-Arcos, Mario Zurita, Erika I. Melchy-Perez, Verónica Narváez-Padilla, Enrique Reynaud   +5 more
doaj   +1 more source

A sex difference in mouse dopaminergic projections from the midbrain to basolateral amygdala

Biology of Sex Differences, 2022
Highlights Cell-type specific labeling of VTA-to-BLA dopaminergic axons and synaptic boutons in mice The intensity of dopaminergic innervation in BLA is intermediate between those in PFC and NAC Dopaminergic axon density in BLA and the size of BLA are ...
Matthew T. C. Manion, Erica R. Glasper, Kuan Hong Wang   +2 more
doaj   +1 more source

Beta burst dynamics in Parkinson’s disease OFF and ON dopaminergic medication

Brain : a journal of neurology, 2017
Exaggerated basal ganglia beta activity (13–35 Hz) is commonly found in patients with Parkinson’s disease and can be suppressed by dopaminergic medication, with the degree of suppression being correlated with the improvement in motor symptoms ...
G. Tinkhauser, A. Pogosyan, H. Tan, D. Herz, A. Kühn, P. Brown   +5 more
semanticscholar   +1 more source

Active inference, evidence accumulation, and the urn task [PDF]

, 2015
Deciding how much evidence to accumulate before making a decision is a problem we and other animals often face, but one that is not completely understood.
Attias H., Beal M. J., Karl Friston, Michael Moutoussis, Philipp Schwartenbeck, Raymond J. Dolan, Schwartenbeck P., Thomas H. B. FitzGerald   +7 more
core   +1 more source

IAP-Based Cell Sorting Results in Homogeneous Transplantable Dopaminergic Precursor Cells Derived from Human Pluripotent Stem Cells

Stem Cell Reports, 2017
Human pluripotent stem cell (hPSC)-derived mesencephalic dopaminergic (mesDA) neurons can relieve motor deficits in animal models of Parkinson's disease (PD).
Daniela Lehnen, Serena Barral, Tiago Cardoso, Shane Grealish, Andreas Heuer, Andrej Smiyakin, Agnete Kirkeby, Jutta Kollet, Harold Cremer, Malin Parmar, Andreas Bosio, Sebastian Knöbel   +11 more
doaj   +1 more source

The Role of Dopamine in Anticipatory Pursuit Eye Movements: Insights from Genetic Polymorphisms in Healthy Adults [PDF]

, 2016
There is a long history of eye movement research in patients with psychiatric diseases for which dysfunctions of neurotransmission are considered to be the major pathologic mechanism.
Billino, Jutta, Gegenfurtner, Karl R., Hennig, Jürgen   +2 more
core   +1 more source

Small molecule inhibits α-synuclein aggregation, disrupts amyloid fibrils, and prevents degeneration of dopaminergic neurons

Proceedings of the National Academy of Sciences of the United States of America, 2018
Significance Parkinson’s disease is characterized by the accumulation of amyloid deposits in dopaminergic neurons, mainly composed of the protein α-synuclein.
Jordi Pujols, Samuel Peña-Díaz, Diana F. Lázaro, Francesca Peccati, F. Pinheiro, Danilo González, Anita Čarija, Susanna Navarro, María Conde-Giménez, Jesús García, S. Guardiola, E. Giralt, X. Salvatella, J. Sancho, M. Sodupe, T. Outeiro, E. Dalfo, S. Ventura   +17 more
semanticscholar   +1 more source

Transcriptional regulation of neuropeptide receptors underlies context‐dependent adaptation in Drosophila melanogaster

FEBS Open Bio, EarlyView.
Under environmental changes, the expression level of neuropeptide (NP) and neuropeptide receptor (NPR) genes changes to confer context‐dependent adaptation to the model organism Drosophila melanogaster. Through finding more regulatory elements in the NPR genes in comparison with their ligands (NPs), we found that NPR‐biased transcriptional regulation ...
SeungHeui Ryu, Yanan Wei, Zekun Wu, Tianmu Zhang, DoHoon Lee, Hadi Najafi, Woo Jae Kim   +6 more
wiley   +1 more source

Evaluation of the Association Between Serum Levels of Testosterone and Prolactin With 6- Hydroxydopamine- Induced Parkinsonism in Male Rats

Basic and Clinical Neuroscience, 2021
Introduction: Parkinson’s Disease (PD) associates with changes in sex hormones; however, it remains unknown whether this is either a cause for or a result of the disease.
Roghaieh Razaghi, Hossein Piri, Hanieh Jafari, Nafiseh Rastgoo, Mohammad Ali Hosseini, Hashem Haghdoost – Yazdi   +5 more
doaj  

Activation of Glutamatergic Neurotransmission by Ketamine: A Novel Step in the Pathway from NMDA Receptor Blockade to Dopaminergic and Cognitive Disruptions Associated with the Prefrontal Cortex

Journal of Neuroscience, 1997
Subanesthetic doses of ketamine, a noncompetitive NMDA receptor antagonist, impair prefrontal cortex (PFC) function in the rat and produce symptoms in humans similar to those observed in schizophrenia and dissociative states, including impaired ...
B. Moghaddam, Barbara W. Adams, A. Verma, D. Daly   +3 more
semanticscholar   +1 more source