Results 61 to 70 of about 392,840 (300)

The Role of Dopamine in Anticipatory Pursuit Eye Movements: Insights from Genetic Polymorphisms in Healthy Adults [PDF]

, 2016
There is a long history of eye movement research in patients with psychiatric diseases for which dysfunctions of neurotransmission are considered to be the major pathologic mechanism.
Billino, Jutta, Gegenfurtner, Karl R., Hennig, Jürgen   +2 more
core   +1 more source

Dopaminergic dynamics underlying sex-specific cocaine reward

Nature Communications, 2017
Although both males and females become addicted to cocaine, females transition to addiction faster and experience greater difficulties remaining abstinent.
E. Calipari, B. Juarez, Carole Morel, D. Walker, M. Cahill, Efrain A. Ribeiro, Ciorana Roman-Ortiz, C. Ramakrishnan, K. Deisseroth, Ming-Hu Han, E. Nestler   +10 more
semanticscholar   +1 more source

Dopaminergic and Non-Dopaminergic Value Systems in Conditioning and Outcome-Specific Revaluation [PDF]

, 2007
Animals are motivated to choose environmental options that can best satisfy current needs. To explain such choices, this paper introduces the MOTIVATOR (Matching Objects To Internal Values Triggers Option Revaluations) neural model.
Bullock, Daniel, Dranias, Mark R., Grossberg, Stephen   +2 more
core   +1 more source

miR-425 deficiency promotes necroptosis and dopaminergic neurodegeneration in Parkinson’s disease

Cell Death and Disease, 2019
A major hallmark of Parkinson’s disease (PD) is the degeneration of dopaminergic neurons in the substantia nigra, and the causative mechanism is thought to be the activation of programmed neuronal death.
Yong-bo Hu, Yong-fang Zhang, Hao Wang, Ru-jing Ren, Hai-lun Cui, Wanying Huang, Q. Cheng, Hong-Zhuan Chen, Gang Wang   +8 more
semanticscholar   +1 more source

High Accuracy Classification of Parkinson's Disease through Shape Analysis and Surface Fitting in $^{123}$I-Ioflupane SPECT Imaging

, 2017
Early and accurate identification of parkinsonian syndromes (PS) involving presynaptic degeneration from non-degenerative variants such as Scans Without Evidence of Dopaminergic Deficit (SWEDD) and tremor disorders, is important for effective patient ...
Ghosh, Shantanu, Mandal, Pravat K., Prashanth, R., Roy, Sumantra Dutta   +3 more
core   +1 more source

Locomotor hyperactivity in 14-3-3Zeta KO mice is associated with dopamine transporter dysfunction [PDF]

, 2013
Dopamine (DA) neurotransmission requires a complex series of enzymatic reactions that are tightly linked to catecholamine exocytosis and receptor interactions on pre- and postsynaptic neurons.
A Abi-Dargham, A Aitken, A Breier, A Vina-Vilaseca, AA Williams, AH Wong, B Giros, B Giros, BL Summers, BT Baune, C Itagaki, CA Tamminga, D Berg, D Sulzer, DL Levy, FA Middleton, H Fu, H Jaaro-Peled, H Khoshbouei, H Koike, HC Baxter, J Sun, J Wang, JA English, JA English, JA Lieberman, JA Lieberman, JH Son, JM van Rossum, K Toska, K Toyo-oka, K Toyo-Oka, KL Holton, M Laruelle, M Laruelle, M Miranda, M Rosner, M van den Buuse, M van den Buuse, MS Samuel, O Halskau Jr., P Coyle, PC Hart, PS Cheah, S Leucht, S Sivagnanasundaram, S Sivagnanasundaram, SG Amara, SR Jones, T Ichimura, T Ichimura, WC Drevets, WT Carpenter, Y Jia   +53 more
core   +2 more sources

A dopaminergic switch for fear to safety transitions

Nature Communications, 2018
Overcoming aversive emotional memories requires neural systems that detect when fear responses are no longer appropriate so that they can be extinguished.
Ray Luo, A. Uematsu, A. Weitemier, Luca Aquili, Jenny Koivumaa, T. McHugh, J. Johansen   +6 more
semanticscholar   +1 more source

Aromatic-Turmerone Analogs Protect Dopaminergic Neurons in Midbrain Slice Cultures through Their Neuroprotective Activities

Cells, 2021
Parkinson’s disease (PD) is a neurodegenerative disorder characterized by the loss of dopaminergic neurons in the substantia nigra. The inflammatory activation of microglia participates in dopaminergic neurodegeneration in PD.
Yuria Hori, Reiho Tsutsumi, Kento Nasu, Alex Boateng, Yasuhiko Ashikari, Masaharu Sugiura, Makoto Nakajima, Yuki Kurauchi, Akinori Hisatsune, Hiroshi Katsuki, Takahiro Seki   +10 more
doaj   +1 more source

Compensatory weight gain due to dopaminergic hypofunction: new evidence and own incidental observations

Nutrition & Metabolism, 2008
There is increasing evidence for a role of dopamine in the development of obesity. More specifically, dopaminergic hypofunction might lead to (over)compensatory food intake.
Bohr Iwo, Breitenstein Caterina, Skopp Oliver, Reinholz Julia, Winterhoff Hilke, Knecht Stefan   +5 more
doaj   +1 more source

Aging-related motor function and dopaminergic neuronal loss in C57BL/6 mice

Molecular Brain, 2020
Aging-related dopaminergic neuronal loss and its motor phenotypes are well known. Excessive loss of dopaminergic neurons leads to Parkinson’s disease (PD), the most common neurodegenerative disorder characterized by the loss of nigrostriatal dopamine ...
Sachiko Noda, Shigeto Sato, Takahiro Fukuda, Norihiro Tada, Nobutaka Hattori   +4 more
doaj   +1 more source