Results 61 to 70 of about 243,277 (347)

Smart Polymeric 3D Microscaffolds Hosting Spheroids for Neuronal Research via Quantum Metrology

Advanced Healthcare Materials, Volume 14, Issue 7, March 14, 2025.
Development of a platform consisting of 3D microscaffolds supporting 3D embryoid bodies for neuronal research. The polymeric scaffolds enable directed growth of neurites. This study shows nanodiamond‐based quantum sensors graft onto the polymer material, enabling quantum metrology experiments within the 3D neuronal model and thereby providing a ...
Beatriz N. L. Costa, Ana Marote, Catarina Barbosa, Jonas Campos, António J. Salgado, Jana B. Nieder   +5 more
wiley   +1 more source

Identification of signaling pathways modifying human dopaminergic neuron development using a pluripotent stem cell-based high-throughput screening automated system: purinergic pathways as a proof-of-principle

Frontiers in Pharmacology, 2023
Introduction: Alteration in the development, maturation, and projection of dopaminergic neurons has been proposed to be associated with several neurological and psychiatric disorders.
Claire Boissart, Marie Lasbareilles, Marie Lasbareilles, Marie Lasbareilles, Johana Tournois, Laure Chatrousse, Thifaine Poullion, Alexandra Benchoua, Alexandra Benchoua   +8 more
doaj   +1 more source

Reward Dependent Invigoration Relates to Theta Oscillations and Is Predicted by Dopaminergic Midbrain Integrity in Healthy Elderly

Frontiers in Aging Neuroscience, 2017
Motivation can have invigorating effects on behavior via dopaminergic neuromodulation. While this relationship has mainly been established in theoretical models and studies in younger subjects, the impact of structural declines of the dopaminergic system
Tineke K Steiger, N. Bunzeck
semanticscholar   +1 more source

Dopaminergic Modulation of Arousal in Drosophila [PDF]

Current Biology, 2005
Arousal levels in the brain set thresholds for behavior, from simple to complex. The mechanistic underpinnings of the various phenomena comprising arousal, however, are still poorly understood. Drosophila behaviors have been studied that span different levels of arousal, from sleep to visual perception to psychostimulant responses.We have investigated ...
Andretic, Rozi, van Swinderen, Bruno, Greenspan, Ralph J.   +2 more
openaire   +5 more sources

Nanomaterial‐Enhanced Biosensing: Mechanisms and Emerging Applications

Advanced Healthcare Materials, EarlyView.
Nanomaterial integration transforms biosensor capabilities through enhanced signal transduction, sensitivity, and selectivity. This review analyzes how nanoscale materials—from nanoparticles to nanosheets—leverage unique physicochemical properties to revolutionize electrochemical, optical, and electrical biosensing.
Younghak Cho, Yunyoung Choi, Yerim Jang, Hyejeong Seong   +3 more
wiley   +1 more source

Full Anatomical Recovery of the Dopaminergic System after a Complete Spinal Cord Injury in Lampreys

Neural Plasticity, 2015
Following a spinal injury, lampreys at first are paralyzed below the level of transection. However, they recover locomotion after several weeks, and this is accompanied by the regeneration of descending axons from the brain and the production of new ...
Blanca Fernández-López, Daniel Romaus-Sanjurjo, María Eugenia Cornide-Petronio, Sonia Gómez-Fernández, Antón Barreiro-Iglesias, María Celina Rodicio   +5 more
doaj   +1 more source

Projections of the Diencephalospinal Dopaminergic System to Peripheral Sense Organs in Larval Zebrafish (Danio rerio)

Frontiers in Neuroanatomy, 2018
Dopaminergic neurons of the descending diencephalospinal system are located in the posterior tuberculum (PT) in zebrafish (Danio rerio), and correspond in mammals to the A11 group in hypothalamus and thalamus. In the larval zebrafish, they are likely the
Melanie Haehnel-Taguchi, António M. Fernandes, António M. Fernandes, Margit Böhler, Ina Schmitt, Lena Tittel, Wolfgang Driever, Wolfgang Driever   +7 more
doaj   +1 more source

Metformin Prevents Dopaminergic Neuron Death in MPTP/P-Induced Mouse Model of Parkinson’s Disease via Autophagy and Mitochondrial ROS Clearance

International Journal of Neuropsychopharmacology, 2016
Background: Our previous study demonstrated that metabolic inflammation exacerbates dopaminergic neuronal degeneration in type 2 diabetes mice. Metformin, a typical oral hypoglycemic agent for diabetes, has been regarded as an activator of AMP-activated ...
Ming Lu, Cun-Jin Su, Chen Qiao, Y. Bian, Jian-hua Ding, G. Hu   +5 more
semanticscholar   +1 more source

Aging on Chip: Harnessing the Potential of Microfluidic Technologies in Aging and Rejuvenation Research

Advanced Healthcare Materials, EarlyView.
This review highlights recent advances in microfluidic technologies for modeling human aging and age‐related diseases. It explores how organ‐on‐chip platforms improve physiological relevance, enable rejuvenation strategies, facilitate drug screening, detect senescent cells, and identify biomarkers.
Limor Zwi‐Dantsis, Vignesh Jayarajan, George M. Church, Roger D. Kamm, João Pedro de Magalhães, Emad Moeendarbary   +5 more
wiley   +1 more source

Dopaminergic Epistases in Schizophrenia

Brain Sciences
Background: The dopaminergic theory, the oldest and most comprehensively analyzed neurotransmitter theory of schizophrenia, remains a focal point of research. Methods: This systematic review examines the association between combinations of 14 dopaminergic genes and the risk of schizophrenia.
Adela Bosun, Raluka Albu-Kalinovic, Oana Neda-Stepan, Ileana Bosun, Simona Sorina Farcas, Virgil-Radu Enatescu, Nicoleta Ioana Andreescu   +6 more
openaire   +3 more sources