Results 71 to 80 of about 134,791 (125)

Discrimination vs. Generation: The Machine Learning Dichotomy for Dopaminergic Hit Discovery [PDF]

arXiv
Virtual screening plays a pivotal role in early drug discovery, traditionally dominated by physics-based methods. While these approaches offer detailed insights, they are often hindered by high computational costs, limited sampling, and forcefield inaccuracies.
arxiv  

Transcription Factor-Mediated Generation of Dopaminergic Neurons from Human iPSCs—A Comparison of Methods

Cells
Dopaminergic neurons are the predominant brain cells affected in Parkinson’s disease. With the limited availability of live human brain dopaminergic neurons to study pathological mechanisms of Parkinson’s disease, dopaminergic neurons have been generated
Kirstin O. McDonald, Nikita M. A. Lyons, Luca K. C. Gray, Janet B. Xu, Lucia Schoderboeck, Stephanie M. Hughes, Indranil Basak   +6 more
doaj   +1 more source

Influence of nicotine and alcohol on sleep latency: the reward-attention circuit model [PDF]

arXiv, 2019
We previously developed a neurocomputational model called the reward-attention circuit, which has been used to investigate the separate effects of nicotine and alcohol on attention focus. The model is based on known circuits linking midbrain dopaminergic neurons to the thalamocortical loop and is sufficiently versatile to capture diverse phenomena.
arxiv  

miR-34b/c Regulates Wnt1 and Enhances Mesencephalic Dopaminergic Neuron Differentiation

Stem Cell Reports, 2018
Summary: The differentiation of dopaminergic neurons requires concerted action of morphogens and transcription factors acting in a precise and well-defined time window. Very little is known about the potential role of microRNA in these events.
Roberto De Gregorio, Salvatore Pulcrano, Claudia De Sanctis, Floriana Volpicelli, Ezia Guatteo, Lars von Oerthel, Emanuele Claudio Latagliata, Roberta Esposito, Rosa Maria Piscitelli, Carla Perrone-Capano, Valerio Costa, Dario Greco, Stefano Puglisi-Allegra, Marten P. Smidt, Umberto di Porzio, Massimiliano Caiazzo, Nicola Biagio Mercuri, Meng Li, Gian Carlo Bellenchi   +18 more
doaj  

One-step cell biomanufacturing platform: porous gelatin microcarrier beads promote human embryonic stem cell-derived midbrain dopaminergic progenitor cell differentiation in vitro and survival after transplantation in vivo

Neural Regeneration Research
Numerous studies have shown that cell replacement therapy can replenish lost cells and rebuild neural circuitry in animal models of Parkinson’s disease.
Lin Feng, Da Li, Yao Tian, Chengshun Zhao, Yun Sun, Xiaolong Kou, Jun Wu, Liu Wang, Qi Gu, Wei Li, Jie Hao, Baoyang Hu, Yukai Wang   +12 more
doaj   +1 more source

MIRO1 mutation leads to metabolic maladaptation resulting in Parkinson's disease-associated dopaminergic neuron loss. [PDF]

NPJ Syst Biol Appl
Zagare A, Sauter T, Barmpa K, Pacheco M, Krüger R, Schwamborn JC, Saraiva C.   +6 more
europepmc   +1 more source

Biofilm proficient Bacillus subtilis prevents neurodegeneration in Caenorhabditis elegans Parkinson's disease models via PMK-1/p38 MAPK and SKN-1/Nrf2 signaling. [PDF]

Sci Rep
Francisco M, Grau R.
europepmc   +1 more source

Dopaminergic changes in the subgenual cingulate cortex in dementia with lewy bodies associates with presence of depression. [PDF]

Transl Psychiatry
Gliaudelytė L, Rushton SP, Berlinguer-Palmini R, Thomas AJ, Morris CM.   +4 more
europepmc   +1 more source

Whole-brain 3D imaging of dopaminergic neurons and glial cells in the mouse model of Parkinson's disease induced by 6-OHDA. [PDF]

Front Aging Neurosci
Wang M, Xiao L, Shi Y, Wu Y, Huang X, Wu Y, Xu Y, Bai L, Pan W, Zhang J, Wang W.   +10 more
europepmc   +1 more source

Nigrostriatal iron accumulation in the progression of Parkinson's disease. [PDF]

NPJ Parkinsons Dis
López-Aguirre M, Balzano T, Monje MHG, Esteban-García N, Martínez-Fernández R, Del Rey NL, Ciorraga M, Sánchez-Ferro A, Trigo-Damas I, Blesa J, Obeso JA, Pineda-Pardo JA.   +11 more
europepmc   +1 more source