Results 211 to 220 of about 116,827 (301)

Variant-specific effects of GBA1 mutations on dopaminergic neuron proteostasis. [PDF]

J Neurochem
Onal G, Yalçın-Çakmaklı G, Özçelik CE, Boussaad I, Şeker UÖŞ, Fernandes HJR, Demir H, Krüger R, Elibol B, Dökmeci S, Salman MM.   +10 more
europepmc   +1 more source

Altered Cerebrospinal Fluid Tryptophan–Kynurenine Pathway Metabolism in Multiple System Atrophy

Movement Disorders, EarlyView.
Abstract Background Alterations in tryptophan–kynurenine (TRP‐KYN) metabolism, which is associated with neuroinflammation, remain unclear in multiple system atrophy (MSA). Objective The aim was to investigate cerebrospinal fluid (CSF) TRP metabolites in MSA and their associations with other biomarkers.
Ryunosuke Nagao, Kazuya Kawabata, Yasuaki Mizutani, Sayuri Shima, Akihiro Ueda, Mizuki Ito, Yasuhiro Maeda, Akihiro Mouri, Hirohisa Watanabe   +8 more
wiley   +1 more source

The Role of ETNPPL in Dopaminergic Neuron Stability: Insights from Neuromelanin-Associated Protein Expression in Parkinson's Disease. [PDF]

Int J Mol Sci
Schillaci FA, Lanza G, Salluzzo MG, L'Episcopo F, Ferri R, Salemi M.   +5 more
europepmc   +1 more source

POLG‐Related Parkinsonism with Good Response to Deep Brain Stimulation

Movement Disorders Clinical Practice, EarlyView.
Evdokia Efthymiou, Fabian Büchele, Sujitha Mahendran, Lennart Stieglitz, Bettina Balint   +4 more
wiley   +1 more source

In Vivo Mapping of Catecholaminergic Loss and Iron Deposition in Huntington's Disease

Movement Disorders, EarlyView.
Abstract Background The pathophysiology of Huntington's disease (HD) remains obscure. Magnetic resonance imaging (MRI) can reveal in vivo molecular changes related to disease pathology. Objectives To investigate catecholaminergic neuronal integrity and subcortical brain iron accumulation in HD employing neuromelanin‐sensitive MRI, and quantitative ...
Edoardo R. de Natale, Heather Wilson, Efstratios Karavasilis, Athanasia Liozidou, Chrisoula Kartanou, Georgios Velonakis, Jens Kuhle, Ioannis Zalonis, Georgia Karadima, Leonidas Stefanis, Georgios Koutsis, Marios Politis   +11 more
wiley   +1 more source

Infiltrating peripheral monocyte TREM-1 mediates dopaminergic neuron injury in substantia nigra of Parkinson's disease model mice. [PDF]

Cell Death Dis
Song W, Zhou ZM, Zhang LL, Shu HF, Xia JR, Qin X, Hua R, Zhang YM.   +7 more
europepmc   +1 more source

Aberrant Beta‐Band Network Alteration Preceding Freezing of Gait in Parkinson's Disease

Movement Disorders, EarlyView.
Abstract Background Freezing of gait (FOG) is a debilitating motor symptom observed in the advanced stages of Parkinson's disease (PD), characterized by an abrupt inability to initiate or continue forward walking. Whole‐brain functional connectivity analysis has shown promise in elucidating the underlying pathophysiology and identifying potential ...
Yanqiu Tian, Elie Matar, Shlomo Berkovsky, Simon J.G. Lewis   +3 more
wiley   +1 more source

Csf1r-mediated depletion of midbrain microglia prevents dopaminergic neuron loss during chronic colitis

Kutscherauer RK, Andert M, Stolzer I, Neumaier EE, Dedden M, Kielkowski P, Xiang W, Grotemeyer A, Prinz M, Masuda T, Knobeloch K, Rothhammer V, Zundler S, Schlachetzki JC, Winkler J, Günther C, Süß P.   +16 more
europepmc   +1 more source

GUCY2C signaling limits dopaminergic neuron vulnerability to toxic insults. [PDF]

NPJ Parkinsons Dis
Cheslow L, Byrne M, Kopenhaver JS, Iacovitti L, Smeyne RJ, Snook AE, Waldman SA.   +6 more
europepmc   +1 more source

Local Field Aperiodic Spectral Power Modulated by Deep Brain Stimulation in Parkinson's Disease

Movement Disorders, EarlyView.
Abstract Background Aperiodic spectral broadband power has been described recently as reflecting Parkinson's disease (PD) severity. It has therefore become an increasing focus of research interest in the context of the new adaptive deep brain stimulation (DBS) approach.
Martin Lamoš, Aneta Žáčková, David Ulčák, Benjamin Gurka, Daniel Brzuchanski, Lucia Šmahovská, Martina Bočková   +6 more
wiley   +1 more source