Results 211 to 220 of about 65,347 (261)
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The International Journal of Biochemistry & Cell Biology, 2005
Dopaminergic neurons of the midbrain are the main source of dopamine (DA) in the mammalian central nervous system. Their loss is associated with one of the most prominent human neurological disorders, Parkinson's disease (PD). Dopaminergic neurons are found in a 'harsh' region of the brain, the substantia nigra pars compacta, which is DA-rich and ...
Shankar J, Chinta, Julie K, Andersen
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Dopaminergic neurons of the midbrain are the main source of dopamine (DA) in the mammalian central nervous system. Their loss is associated with one of the most prominent human neurological disorders, Parkinson's disease (PD). Dopaminergic neurons are found in a 'harsh' region of the brain, the substantia nigra pars compacta, which is DA-rich and ...
Shankar J, Chinta, Julie K, Andersen
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Dopaminergic neurons intrinsic to the striatum
Journal of Neurochemistry, 2007AbstractThe striatum – the largest integrative component of the basal ganglia – harbors a population of neurons that express the enzyme tyrosine hydroxylase (TH), a faithful marker of dopaminergic neurons. The dopaminergic nature of these neurons is further supported by the fact that they express the dopamine (DA) transporter (DAT) and the nuclear ...
Philippe, Huot, André, Parent
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Dopaminergic neurons in the human retina
Journal of Comparative Neurology, 1982AbstractThe utilization of dopamine in the adult human retina was examined by using high‐affinity uptake, localization, synthesis, and release as neurotransmitter‐specific physiological probes. Autoradiographic and histochemical studies have shown that dopamine‐accumulating and dopamine‐containing cells of the human retina belong to a population of ...
J M, Frederick +4 more
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Toxicity of semaphorin3A for dopaminergic neurons
Neuroscience Letters, 2005Semaphorin3A (Sema3A) is known to cause neuronal apoptosis and serves as a chemorepellent factor for axonal growth. In our previous report, we found that Sema3A was up-regulated in the 6-OHDA-injected striatum of rats, suggesting that Sema3A was likely involved in dopaminergic (DA) depletion.
Takao, Yasuhara +11 more
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Dopaminergic Dependency of Cholinergic Pallidal Neurons
Neuroscience, 2023We employed the whole-cell patch-clamp method and ChAT-Cre mice to study the electrophysiological attributes of cholinergic neurons in the external globus pallidus. Most neurons were inactive, although approximately 20% displayed spontaneous firing, including burst firing.
Janintzitzic López-Niño +7 more
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Dopaminergic neurons for Parkinson's therapy
Nature Biotechnology, 2012A differentiation protocol guided by developmental principles produces more-authentic dopaminergic neurons for transplantation in patients.
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Noradrenergic Modulation on Dopaminergic Neurons
Neurotoxicity Research, 2018It is now well accepted that there is a close relationship between noradrenergic and dopaminergic neurons in the brain, especially referring to the modulation of the locus coeruleus-norepinephrine (LC-NE) system on dopamine transmission. The disturbance of this modulation may contribute to neurodegeneration of dopaminergic neurons in Parkinson's ...
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A Diet for Dopaminergic Neurons?
2009Parkinson's disease (PD) is the second most common neurodegenerative disease, which unfortunately is still fatal. Since the discovery of dopamine (DA) neuronal cell loss within the substantia nigra in PD, the past decades have seen the understanding of the pathophysiological mechanisms underlying the degenerative process advance at a very impressive ...
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Aberrant accumulation of serotonin in dopaminergic neurons
Neuroscience Letters, 2006Gene targeting approaches greatly facilitate insight into the functioning of monoamine transporters, the targets of potent antidepressants. The serotonin transporter (5-HTT) is the molecular target of a large number of antidepressants. To assess the clearance of serotonin (5-HT) in the absence of the 5-HTT, we have generated double knockout mice ...
Rainald, Mössner +4 more
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Dopaminergic Neurons in the Cat Retina
Optometry and Vision Science, 1988ABSTRACT Dopaminergic neurons have been directly visualized in the flat mount cat retina with an immunohistochemical technique that uses antisera directed to the enzyme tyrosine hydroxylase. In a previous study, three specific neuronal populations‐amacrine cells, displaced amacrine (DA) cells, and interplexiform (IP) cells‐were ...
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