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ELECTROPHYSIOLOGICAL EFFECTS OF AMPHETAMINE ON DOPAMINERGIC NEURONS
Biochemical Pharmacology, 1973Publisher Summary This chapter elaborates the electrophysiological effects of amphetamine on dopaminergic neurons. Antipsychotic phenothiazines and haloperidol were shown to reverse, and block the depressant effect of d-AMP. In addition, one found that blockade of DA synthesis by the intra-peritoneal administration of 50 mg/kg of the tyrosine ...
George K. Aghajanian, Benjamin S. Bunney
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Noradrenergic Modulation on Dopaminergic Neurons
Neurotoxicity Research, 2018It is now well accepted that there is a close relationship between noradrenergic and dopaminergic neurons in the brain, especially referring to the modulation of the locus coeruleus-norepinephrine (LC-NE) system on dopamine transmission. The disturbance of this modulation may contribute to neurodegeneration of dopaminergic neurons in Parkinson's ...
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Development of the dopaminergic neurons in the rodent brainstem
Experimental Neurology, 2005The loss of dopaminergic (DA) neurons in the ventral midbrain is the principal cause of Parkinson's disease. The search for candidate molecules that promote the genesis and survival capacities of DA neurons is a major area of investigation and hope. A better characterization of the developmental pathways that govern the specification, differentiation ...
Olivier Cases +2 more
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Dopaminergic Neurons in the Cat Retina
Optometry and Vision Science, 1988Dopaminergic neurons have been directly visualized in the flat mount cat retina with an immunohistochemical technique that uses antisera directed to the enzyme tyrosine hydroxylase. In a previous study, three specific neuronal populations--amacrine cells, displaced amacrine (DA) cells, and interplexiform (IP) cells--were identified on the basis of ...
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Tuberoinfundibular neurons: Dopaminergic and norepinephrinergic sensitivity
Brain Research, 1975The techniques of microelectrophoresis and antidromic identification have been utilized in the female rat anesthetized with urethane to localize the tuberoinfundibular neurons and to determine their pharmacological sensitivity to dopamine (DA), norepinephrine (NE) and glutamate (GLUT).
Robert L. Moss +2 more
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Aberrant accumulation of serotonin in dopaminergic neurons
Neuroscience Letters, 2006Gene targeting approaches greatly facilitate insight into the functioning of monoamine transporters, the targets of potent antidepressants. The serotonin transporter (5-HTT) is the molecular target of a large number of antidepressants. To assess the clearance of serotonin (5-HT) in the absence of the 5-HTT, we have generated double knockout mice ...
Alexander Marx +4 more
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The mesocortico-prefrontal dopaminergic neurons
Trends in Neurosciences, 1984The mesocortico-prefrontal dopaminergic neurons represent a dopaminergic subsystem which is distinct from other ascending dopaminergic pathways. Via their inhibitory modulatory influence on cortical efferent neurons, they can indirectly regulate DA transmission in subcortical structures and hence may participate in the control of motor activity ...
Jean-Pol Tassin +2 more
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How to make a mesodiencephalic dopaminergic neuron
Nature Reviews Neuroscience, 2007Dopaminergic neurons located in the ventral mesodiencephalon are essential for the control of voluntary movement and the regulation of emotion, and are severely affected in neurodegenerative diseases such as Parkinson's disease. Recent advances in molecular biology and mouse genetics have helped to unravel the mechanisms involved in the development of ...
Marten P. Smidt, J. Peter H. Burbach
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Genetic control of dopaminergic neuron differentiation
Trends in Neurosciences, 2005The mesencephalic dopaminergic (mesDA) system controls movement and emotional behaviour, and its degeneration causes Parkinson's disease and other psychiatric disorders. Recent findings are leading to better understanding of the genetic control of generation and functioning of the mesDA system.
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Regulatory aspects of nigrostriatal dopaminergic neurons
Experimental Brain Research, 1992In the urethane-anesthetized rat, electrical stimulation (10 Hz, 30 s, 250 microA) of the medial forebrain bundle (MFB), at 20-min intervals over an 8-h period, combined with intracerebral microdialysis in the striatum caused: an undiminished increase in the release of dopamine (DA) with each stimulation episode; a decreased efflux of 3,4 ...
Gino Toffano +3 more
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