Results 111 to 120 of about 6,860 (236)

Pharmacotherapy of Complicated Urinary Tract and Intra-abdominal Infections with Doripenem

, 2009
Due to the growing rate of multi-drug resistant bacteria in complicated infections, the need for new broad-spectrum antimicrobials is paramount. Doripenem, a new addition to the intravenous carbapenem class, has recently been approved for the treatment ...
David P. Nicolau, Joseph L. Kuti, Anthony M. Nicasio   +2 more
core   +1 more source

Assessing the pharmacodynamic profile of intravenous antibiotics against prevalent Gram-negative organisms collected in Colombia

Brazilian Journal of Infectious Diseases
OBJECTIVES: This study was designed to simulate standard and optimized dosing regimens for intravenous antibiotics against contemporary populations of Escherichia coli, Klebsiella pneumoniae, Acinetobacter baumannii, and Pseudomonas aeruginosa using MIC ...
Maria Virginia Villegas, David Felipe Briceno, Sory Jamil Ruiz, Guilherme H Furtado, David P Nicolau   +4 more
doaj   +1 more source

Population Pharmacokinetic Analysis of Doripenem after Intravenous Infusion in Korean Patients with Acute Infections

, 2017
We investigated the population pharmacokinetics (PK) of doripenem in Korean patients with acute infections and determined an appropriate dosing regimen using a Monte Carlo simulation for predicting pharmacodynamics (PD). Patients ( n
Kyubok Jin, Sungmin Kiem, Yang Wook Kim, Jae-Gook Shin, Yong Kyun Kim, Myoung Joo Kang, Young Soo Moon, Dong-Hwan Lee, Young-Don Joo   +8 more
core   +1 more source

Doripenem population pharmacokinetics and dosing requirements for critically ill patients receiving continuous venovenous haemodiafiltration

, 2014
Objectives: Doripenem is a newer carbapenem with little data available to guide effective dosing during renal replacement therapy in critically ill patients.
Starr, Therese, Bulitta, Juergen B., Lipman, Jeffrey, Udy, Andrew A., Roberts, Natasha A., Lassig-Smith, Melissa, Stuart, Janin, Wallis, Steven C., Dunlop, Rachel, Jarrett, Paul, Roberts, Jason A., Hayashi, Yoshiro   +11 more
core   +1 more source

Selection of a surrogate beta-lactam testing agent for initial susceptibility testing of doripenem, a new carbapenem

, 2007
Doripenem, a broad-spectrum parenteral carbapenem, has potency and pharmacokinetic/pharmacodynamic features most similar to imipenem and meropenem. Because of potential delays in release of commercial testing devices post-regulatory approval (US Food and
Fritsche, Thomas R., Jones, Ronald N., Sader, Helio S. [UNIFESP], Janechek, Michael J.   +3 more
core   +1 more source

Antimicrobial efficacy of doripenem and its combinations with sulbactam, amikacin, colistin, tigecycline in experimental sepsis of carbapenem-resistant Acinetobacter baumannii

, 2015
Acinetobacter baumannii is the most common species to have developed resistance to antibiotics. Due to increasing levels of drug resistance, the available therapeutic options are insufficient in A. baumannii infections.
Doğanay, Mehmet, Ahmed, Salman Shaheer, Elmali, Ferhan, Alp, Emine, Dinç, Gökçen, Demiraslan, Hayati   +5 more
core  

A PROspective study on the Usage patterns of Doripenem in the Asia-Pacific region (PROUD study)

, 2014
Doripenem is approved in the Asia-Pacific (APAC) region for treating nosocomial pneumonia (NP) including ventilator-associated pneumonia (VAP), complicated intra-abdominal infections (cIAIs) and complicated urinary tract infections (cUTIs).
Van Kinh, Nguyen, Chan, Wai Ming, Loo, Chian Min, Mustafa, Mahiran, Garcia, Jemelyn, Lee, Christopher, Anh, Nguyen Dat, Harijanto, Eddy   +7 more
core   +1 more source

Optimal doripenem dosing simulations in critically ill nosocomial pneumonia patients with obesity, augmented renal clearance and decreased bacterial susceptibility

, 2013
Objective: Doripenem is a valuable broad-spectrum antibiotic for empirical therapy in critically ill patients, although little data exist to guide effective dosing.
Lipman, Jeffrey, Roberts, Jason
core   +1 more source

Impact of hospital formulary intervention on carbapenem use: a segmented time-series analysis of consumption and a propensity score-matched non-inferiority study of treatment efficacy

Journal of Pharmaceutical Health Care and Sciences
Background Pharmaceutical formularies play a crucial role in guiding medication use by balancing clinical effectiveness and cost efficiency. Although formulary implementation has been increasing in Japan, comprehensive evaluations of its impact on both ...
Nakaba Okamura, Ayano Katagiri, Tomoya Komori, Kei Kawanabe, Hirofumi Koike, Yukiko Sahashi, Rie Kubota   +6 more
doaj   +1 more source

Comparative in vitro susceptibility of Burkholderia pseudomallei to doripenem, ertapenem, tigecycline and moxifloxacin

, 2011
Burkholderia pseudomallei, the causative agent of melioidosis, continues to present therapeutic challenges in endemic areas. A number of clinical issues have prompted consideration of alternative antimicrobial therapies.
Harris, Patrick, Cathy Engler, Robert Norton, Norton, Robert, Engler, Cathy, Patrick Harris   +5 more
core   +1 more source