Results 101 to 110 of about 6,860 (236)

Doripenem versus Pseudomonas aeruginosa in vitro: Activity against characterized isolates, mutants, and transconjugants and resistance selection potential

, 2004
Doripenem is a broad-spectrum parenteral carbapenem under clinical development in Japan and North America. Its activities against (i) Pseudomonas aeruginosa isolates with graded levels of intrinsic efflux-type resistance, (ii) mutants with various ...
Ge, Yigong, Livermore, David M., Mushtaq, Shazad   +2 more
core   +1 more source

Nozokomiyal Pseudomonas Aerugınosa İzolatlarında Doripenem Duyarlılık Oranlarının E-Test Yöntemiyle Araştırılması

Sakarya Tıp Dergisi, 2011
Amaç: Karbapenemlerin en yeni üyesi olan ve ülkemizde son dönemde kullanıma giren doripenemin nozokomiyal Pseudomonas aeruginosa (P.aeruginosa) izolatlarında in-vitro etkinliğinin araştırılması amaçlanmıştır.Gereç ve Yöntem: Bu amaçla 2008-2010 yılları
Abdullah Bektaş, Aytekin Çıkman, Görkem Yaman, Hüseyin Güdücüoğlu, Mustafa Berktaş   +4 more
doaj   +1 more source

CLINICAL AND PHARMACOECONOMIC ANALYSIS OF CARBAPENEMS (MEROPENEM, IMIPENEM AND DORIPENEM) IN NOSOCOMIAL PNEUMONIA TREATMENT

Фармакоэкономика, 2015
the article presents the results of a retrospective study conducted in the period from 2008 to 2011 in Moscow’s hospitals. The aim of the study was to compare the clinical and pharmacoeconomical efficacy of carbapenems in nosocomial pneumonia treatment ...
I. I. Shteynberg, S. K. Zyryanov, Yu. B. Belousov   +2 more
doaj  

Antimicrobial activity of doripenem against Gram-negative pathogens: results from INVITA-A-DORI Brazilian study

Brazilian Journal of Infectious Diseases
In vitro activity of doripenem and comparator antimicrobial agents was evaluated against Gram-negative bacilli recently isolated from Brazilian private hospitals that were enrolled in the INVITA-A-DORI Brazilian Study. A total of 805 unique Gram-negative
Ana Cristina Gales, Heber D Azevedo, Rosângela Ferraz Cereda, Raquel Girardello, Danilo Elias Xavier   +4 more
doaj   +1 more source

Assessing the pharmacodynamic profile of intravenous antibiotics against prevalent Gram-negative organisms collected in Colombia

Brazilian Journal of Infectious Diseases, 2011
Objectives: This study was designed to simulate standard and optimized dosing regimens for intravenous antibiotics against contemporary populations of Escherichia coli, Klebsiella pneumoniae, Acinetobacter baumannii, and Pseudomonas aeruginosa using MIC ...
Maria Virginia Villegas, MD, MSc, David Felipe Briceno, MD, Sory Jamil Ruiz, MD, Guilherme H. Furtado, MD, David P. Nicolau, PharmD, FCCP, FIDSA   +4 more
doaj   +1 more source

Efficacy of doripenem against Escherichia coli and Klebsiella pneumoniae in experimental meningitis

, 2017
Objectives In this study the efficacy of doripenem, a new broad-spectrum carbapenem, was tested against an Escherichia coli strain and a Klebsiella pneumoniae strain in an experimental animal model. The comparator was cefepime monotherapy.
Egerman, Ueli, Stucki, Armin, Acosta, Fernando, Cottagnoud, Marianne, Laeuffer, Jörg M., Cottagnoud, Philippe   +5 more
core  

Target site Konzentration von Doripenem in subkutanem und muskulärem Gewebe in Intensivpatienten

, 2017
Doripenem (Doribax™) ist ein Breitband Carbapenem, das sowohl gegen Gram positive als auch Gram negative Bakterien wirksam ist. Voraussetzung für eine effiziente Wirkung ist das Erreichen einer ausreichenden Konzentration am Infektionsort.
Köfinger, Petra
core  

Pharmacokinetic and Pharmacodynamic Evaluation of Doripenem in Critically Ill Trauma Patients with Sepsis.

, 2016
Click on the Resource Link to access the article (may not be free).BACKGROUND: Doripenem is approved by the Food and Drug Administration for the treatment of patients with complicated intra-abdominal infections and complicated urinary tract infections ...
Morse, Bryan, Lodise, Thomas P, Chester, Katleen, Curzio, Karen, Williams, Brian, Salomone, Jeffrey, Chaar, Mitchell, Rahbar, Aryan J, Abraham, Prasad, Pai, Manjunath P, Rabinovich, Marina, Huang, Vanthida, Patka, John, Lockwood, Alissa   +13 more
core   +1 more source

Penetration of Doripenem into Skeletal Muscle and Subcutaneous Adipose Tissue in Healthy Volunteers

, 2012
Sufficient antibiotic concentrations at the infection site are a prerequisite for good bacterial killing. This study was performed to determine pharmacokinetics of doripenem in soft tissues and saliva.
Gottfried Reznicek, Bernhard Burian, Oliver Donath, Robert Sauermann, Markus Zeitlinger   +4 more
core   +1 more source

Pharmacodynamic Profiling of Antimicrobials against Gram-negative Respiratory Isolates from Canadian Hospitals

Canadian Journal of Infectious Diseases and Medical Microbiology, 2011
The objective of this study was to assess the profile of a variety of dosing regimens for common intravenous antibiotics against contemporary Enterobacter cloacae, Escherichia coli, Klebsiella pneumoniae and Pseudomonas aeruginosa isolates collected in ...
Rebecca A. Keel, George G. Zhanel, Sheryl Zelenitsky, David P. Nicolau   +3 more
doaj   +1 more source