Results 91 to 100 of about 5,549 (198)

Assessing the pharmacodynamic profile of intravenous antibiotics against prevalent Gram-negative organisms collected in Colombia

Brazilian Journal of Infectious Diseases
OBJECTIVES: This study was designed to simulate standard and optimized dosing regimens for intravenous antibiotics against contemporary populations of Escherichia coli, Klebsiella pneumoniae, Acinetobacter baumannii, and Pseudomonas aeruginosa using MIC ...
Maria Virginia Villegas, David Felipe Briceno, Sory Jamil Ruiz, Guilherme H Furtado, David P Nicolau   +4 more
doaj   +1 more source

Doripenem versus Pseudomonas aeruginosa in vitro: Activity against characterized isolates, mutants, and transconjugants and resistance selection potential

, 2004
Doripenem is a broad-spectrum parenteral carbapenem under clinical development in Japan and North America. Its activities against (i) Pseudomonas aeruginosa isolates with graded levels of intrinsic efflux-type resistance, (ii) mutants with various ...
Ge, Yigong, Livermore, David M., Mushtaq, Shazad   +2 more
core   +1 more source

Penetration of Doripenem into Skeletal Muscle and Subcutaneous Adipose Tissue in Healthy Volunteers

, 2012
Sufficient antibiotic concentrations at the infection site are a prerequisite for good bacterial killing. This study was performed to determine pharmacokinetics of doripenem in soft tissues and saliva.
Gottfried Reznicek, Bernhard Burian, Oliver Donath, Robert Sauermann, Markus Zeitlinger   +4 more
core   +1 more source

Impact of hospital formulary intervention on carbapenem use: a segmented time-series analysis of consumption and a propensity score-matched non-inferiority study of treatment efficacy

Journal of Pharmaceutical Health Care and Sciences
Background Pharmaceutical formularies play a crucial role in guiding medication use by balancing clinical effectiveness and cost efficiency. Although formulary implementation has been increasing in Japan, comprehensive evaluations of its impact on both ...
Nakaba Okamura, Ayano Katagiri, Tomoya Komori, Kei Kawanabe, Hirofumi Koike, Yukiko Sahashi, Rie Kubota   +6 more
doaj   +1 more source

Doripenem [PDF]

, 2020
openaire   +1 more source

Antimicrobial Activity of Doripenem Tested Against Leading Bacterial Pathogens: Results from a Latin American Surveillance Study (2003-2006)

, 2008
Carbapenems have been the therapeutic choice for empirical treatment of serious infections when multidrug-resistant Gram-negative organisms are suspected.
Gales, Ana Cristina [UNIFESP], Sader, Helio Silva [UNIFESP], Fritsche, Thomas R., Jones, Ronald N.   +3 more
core  

Citrobacter freundii multirresistente como agente etiológico de infección de vías urinarias

Kasmera, 2019
: Citrobacter freundii, sometimes it can act as opportunistic pathogen, a case of this isolated microorganism is presented as an etiological agent of urinary tract infection, in a patient with chronic obstructive pulmonary disease.
Ullauri-González, Carmen, Freire-Cuesta, Sandra.   +1 more
doaj  

Synergistic activity of dual β-lactams against <i>Mycobacterium avium</i> complex. [PDF]

Microbiol Spectr
Shin E, Dousa KM, Nantongo M, Kurz SG, Holland SM, Kreiswirth BN, Bonomo RA.   +6 more
europepmc   +1 more source

A multi-stage computational pipeline for repurposing FDA-approved drugs: application to EGFR C797S-mutant NSCLC. [PDF]

Front Chem
Alturki MS, Alkhodier RA, Al Khzem AH, Almuzaini OK, Wali SM, Aldosarry KN, Halawi AA, Aldawsari MF, Alruwili WR, Gomaa MS.   +9 more
europepmc   +1 more source

Adsorption of doripenem and meropenem antibiotics on activated carbon derived from snake fruit seeds: single-compound and binary mechanism via experiments and modelling. [PDF]

Sci Rep
Alzahrani EA, Sellaoui L, Soetaredjo FE, Bouzidi M, Abdelwahab A, Alsaif NOS, Alshammari NS, Erto A, Ismadji S.   +8 more
europepmc   +1 more source