Results 91 to 100 of about 653,638 (208)

Curcumin in the Treatment of Various Diseases: Mechanism of Action, Bioavailability, Therapeutic Effects, and Current Clinical Trials

MedComm, Volume 7, Issue 11, November 2026.
Curcumin, a naturally occurring polyphenol, exhibits significant anti‐inflammatory and antioxidant capabilities. This review elucidates the specific molecular mechanisms by which curcumin exerts therapeutic effects on various diseases, including neurological disorders, cardiovascular diseases, cancers, inflammatory disorders, and autoimmune diseases ...
Lin Wang, Qifei Pan, Wenjuan Long, Xinyao Li, Jianqin Mao, Sitong Zhou, Zihui Wang, Xuelian Zou, Yuqing She, Mingqin Shi, Yang Zhou, Jiarong Du, Zhongyang Hu, Xiaoman Lv, Yishu Chen, Dongdong Qin   +15 more
wiley   +1 more source

Differential effects of ipsapirone on 5-HT release in the dorsal and median raphe neuronal pathways

, 1996
Serotonergic neurons of the dorsal and median raphe nuclei are morphologically dissimilar. Recent results challenge previous evidence indicating a greater inhibition of dorsal raphe neurons after 5-hydroxytryptamine1A (5-HT1A) autoreceptor activation. As
Artigas, Francesc, Francesc Artigas, Casanovas, Josep M., Josep M. Casanovas   +3 more
core   +1 more source

Human brain matters: Navigating the neuropathology of COVID‐19

Brain Pathology, Volume 36, Issue 6, November 2026.
Severe COVID‐19 is associated with vascular dysregulation and chronic neuroinflammation, leading to axonal injury and neurodegeneration. In long COVID or PASC, persistent alterations in neuroimaging and biofluid biomarkers reflect ongoing neuronal damage and neuroinflammation, contributing to long‐term neurological symptoms including fatigue, cognitive
Juliana M. Nieuwland, Angelica Scaramuzza, Marianna Bugiani, Wilma D. J. van de Berg, Jinte Middeldorp   +4 more
wiley   +1 more source

Opioid Modulation of Major Neurotransmitter Systems: Acute, Chronic, and Withdrawal Effects

European Journal of Neuroscience, Volume 64, Issue 9, November 2026.
Opioids are widely used but also frequently misused drugs that affect multiple neurotransmitter systems, including dopaminergic, glutamatergic, GABAergic, serotonergic, and cholinergic pathways. Opioid‐induced neuroadaptations depend on the duration of drug exposure, with distinct changes also emerging following drug discontinuation.
Daniela Novakova, Eliska Pritulova, Jiri Novotny   +2 more
wiley   +1 more source

Distribution of Raphespinal Fibers in the Mouse Spinal Cord

Molecular Pain, 2015
Background Serotonergic raphespinal neurons and their fibers have been mapped in large mammals, but the non-serotonergic ones have not been studied, especially in the mouse. The present study aimed to investigate the termination pattern of fibers arising
Huazheng Liang, Shaoshi Wang, Richard Francis, Renee Whan, Charles Watson, George Paxinos   +5 more
doaj   +1 more source

Photoperiodic Regulation of SK Channels in Dorsal Raphe Serotonin Neurons

European Journal of Neuroscience, Volume 64, Issue 9, November 2026.
Long summer‐like photoperiod reduces SK channel function in dorsal raphe serotonin neurons. SK channel blockade with apamin increases firing rate in slices from short‐photoperiod mice, mimicking the elevated firing seen in long‐photoperiod mice. Whole‐cell recordings show that apamin‐sensitive tail currents are smaller in long‐photoperiod neurons ...
Manuel A. Giannoni‐Guzmán, José C. Zepeda, Anna Kamitakahara, Valerie Magalong, Pat Levitt, Brad A. Grueter, Douglas G. McMahon   +6 more
wiley   +1 more source

Clinical Trajectory of Late‐Onset Delusional Disorder Toward Evolving Dementia With Lewy Bodies

Psychogeriatrics, Volume 26, Issue 6, November 2026.
ABSTRACT Recent clinical observations indicate that late‐onset psychosis can precede the onset of dementia with Lewy bodies (DLB). However, its longitudinal clinical trajectory remains poorly understood. Delusional disorder (DD) in older adults is relatively uncommon and poor insight frequently leads to refusal of psychiatric care, limiting available ...
Hiroshige Fujishiro, Kazuhiro Takeda, Kuniyuki Iwata‐Endo, Shusei Arafuka, Seiko Miyata, Kunihiro Iwamoto, Youta Torii, Shuji Iritani   +7 more
wiley   +1 more source

Sodium Salicylate Suppresses GABAergic Inhibitory Activity in Neurons of Rodent Dorsal Raphe Nucleus

, 2015
Sodium salicylate (NaSal), a tinnitus inducing agent, can activate serotonergic (5-HTergic) neurons in the dorsal raphe nucleus (DRN) and can increase serotonin (5-HT) level in the inferior colliculus and the auditory cortex in rodents.
Wang, Wei-Wen, Chen, Liang, Jin, Yan, Chen, Lin, Wang, Xin-Xing, Luo, Bin, Su, Yan-Yan, Wang, Ming   +7 more
core  

Electrophysiological assessment of putative antagonists of 5-hydroxytryptamine receptors: a single-cell study in the rat dorsal raphe nucleus

, 1989
The intravenous administration of low doses of lysergic acid diethylamide (LSD) or of the selective 5-hydroxytryptamine1A (5-HT1A) receptor agonist 8-hydroxy-2-(di-n-propylamino)tetralin (8-OH-DPAT) depresses the firing activity of dorsal raphe 5-HT ...
Suzanne Steinberg, Pierre Blier, Claude de Montigny, Yves Chaput   +3 more
core   +1 more source

Whole-brain mapping of projection from mouse lateral septal nucleus

Biology Open, 2019
The lateral septal nucleus (LS) plays a critical role in emotionality, social behavior and feeding processes, through neural connections with the hippocampus and hypothalamus.
Ke Deng, Lu Yang, Jing Xie, He Tang, Gui-Sheng Wu, Huai-Rong Luo   +5 more
doaj   +1 more source