Results 71 to 80 of about 653,638 (208)

Characterization of transgenic mouse models targeting neuromodulatory systems reveals organizational principles of the dorsal raphe

open access: yesNature Communications, 2019
In addition to serotonin neurons, the dorsal raphe nucleus (DR) also contains dopamine, glutamate, and GABA neurons. Here, the authors systematically compare the neurochemical identity, cell type specificity, anatomical distribution, and connectivity of ...
Daniel F. Cardozo Pinto   +10 more
doaj   +1 more source

Potential health benefits of cold‐water immersion: the central role of PGC‐1α

open access: yesThe Journal of Physiology, EarlyView.
Abstract figure legend Cold‐water immersion (CWI) elicits autonomic, somato‐motoric (shivering thermogenesis), endocrine and metabolic, sensory transduction, and local biophysical effects that may converge on the transcriptional co‐activator PGC‐1α (centre).
Erich Hohenauer   +2 more
wiley   +1 more source

Correlations with raphe nucleus.

open access: yes, 2019
Correlations with raphe nucleus.
Russell Schachar (760461)   +5 more
core   +1 more source

A brain-wide functional map of the serotonergic responses to acute stress and fluoxetine

open access: yesNature Communications, 2019
Serotonin is released throughout the brain from diverse projections of neurons in the dorsal raphe nucleus. Here, the authors use optogenetics and fMRI mediated mapping of the mouse brain-wide serotonin network in response to acute stress and treatment ...
Joanes Grandjean   +10 more
doaj   +1 more source

Slow motion

open access: yeseLife, 2017
Optogenetic stimulation of serotonin neurons in the dorsal raphe causes mice to move more slowly without causing any apparent motor deficits or anxiety-like effects.
Naoshige Uchida, Jeremiah Y Cohen
doaj   +1 more source

VlPAG/DRN Microglia Drive Neuropathic Pain‐Induced Depression via a Defined Neuroimmune Axis

open access: yesAdvanced Science, Volume 13, Issue 61, 3 November 2026.
Peripheral nerve injury (SNI) induces neuropathic pain, activates midbrain microglia, and triggers an NLRP3–IL‐1β–dependent inflammatory cascade. IL‐1β signals through IL‐1R1 on vlPAG/DRN VGLUT2+ neurons (vlPAG/DRNGlu), inducing hyperexcitability and driving the vlPAG/DRNGlu→BNSTGABA circuit to produce the affective component of neuropathic pain ...
Jing Yang   +7 more
wiley   +1 more source

Two-Pronged Control of the Dorsal Raphe by the VTA.

open access: yes, 2019
© 2019 Elsevier Inc. In this issue of Neuron, Li et al. (2019) distinguish two separable GABAergic projections from the ventral tegmental area (VTA) to the dorsal raphe nucleus (DRN), with differential μ-opioid receptor regulation, each targeting ...
Kauer, Julie A   +3 more
core   +1 more source

A retinoraphe projection regulates serotonergic activity and looming-evoked defensive behaviour

open access: yesNature Communications, 2017
Neural circuits underlying innate fear are only partially understood. Huanget al. identify a subset of retinal ganglion cells that project to both the dorsal raphe nucleus and the superior colliculus, and show that these RGCs mediate looming-evoked ...
Lu Huang   +15 more
doaj   +1 more source

Therapeutic Prospects of Ketamine for Cataplexy in Narcolepsy Type 1: Evidence from a Human Case and a Murine Model

open access: yesAnnals of Neurology, Volume 100, Issue 5, Page 1023-1027, November 2026.
Narcolepsy type 1 is characterized by cataplexy, for which current treatments targeting monoaminergic, histaminergic, and GABAergic pathways may be ineffective or poorly tolerated. We report the case of a 34‐year‐old man with narcolepsy type 1, intolerant to standard therapies, who experienced marked and sustained cataplexy reduction with morning ...
Francois Ricordeau   +8 more
wiley   +1 more source

Involvement of lateral habenula-dorsal raphe neurons in the differential regulation of striatal and nigral serotonergic transmission cats

open access: yes, 1982
The importance of the lateral habenula-dorsal raphe pathway in the control of in vivo [3H]serotonin release in the cat basal ganglia was examined using the push-pull cannula technique and an isotopic method for the estimation of [3H]serotonin ...
TD Reisine   +3 more
core   +1 more source

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