Results 51 to 60 of about 653,638 (208)

Global DNA Methylation in the Limbic System of Cattle

open access: yesEpigenomes, 2019
To elucidate the extent to which DNA methylation varies across multiple tissues in the brain and between animals, we have quantified global DNA methylation in tissues comprising the limbic system for six Red Angus x Simmental steers.
Bonnie Cantrell   +6 more
doaj   +1 more source

Bidirectional Pathological Axis Between Alzheimer's Disease and Circadian Rhythm Disturbance: Mechanisms and Therapeutic Strategies

open access: yesiNew Medicine, EarlyView.
This graphical abstract illustrates a bidirectional vicious cycle between Alzheimer’s disease (AD) and circadian rhythm disturbance (CRD). On the one hand, AD pathology, including amyloid‐β (Aβ) plaque deposition and tau hyperphosphorylation, may damage the suprachiasmatic nucleus (SCN) and disrupt melatonin signaling, leading to sleep fragmentation ...
Jiajia Qin   +10 more
wiley   +1 more source

PSA-NCAM immunoreactivity in the dorsal raphe nucleus, mPFC, and amygdala of fluoxetine and methylcellulose treated adolescent and adult rats.

open access: yes, 2013
Data are presented as mean ± S.E.M. of the numer of immunoreactive neurons in the dorsal raphe nucleus (A), mPFC (B), and amygdala (C) (n = 4–5) per 100×100 µm.
Liesbeth Reneman (301735)   +8 more
core   +1 more source

Transient inhibition and long-term facilitation of locomotion by phasic optogenetic activation of serotonin neurons

open access: yeseLife, 2017
Serotonin (5-HT) is associated with mood and motivation but the function of endogenous 5-HT remains controversial. Here, we studied the impact of phasic optogenetic activation of 5-HT neurons in mice over time scales from seconds to weeks.
Patrícia A Correia   +5 more
doaj   +1 more source

Identifiable regional and neural network abnormalities in early childhood anxiety

open access: yesJCPP Advances, EarlyView.
Abstract Background Although the neural underpinnings of anxiety have been investigated, most research has been confined to adolescence and adulthood, with less of a focus on the early childhood period. Little is known about the role of anticipatory fear processing early childhood, which is a sensitive period for anxiety development.
Khalil I. Thompson   +7 more
wiley   +1 more source

Research Progress on Upper Airway Cough Syndrome

open access: yesWorld Journal of Otorhinolaryngology - Head and Neck Surgery, EarlyView.
ABSTRACT Upper airway cough syndrome (UACS) has been identified as a significant contributor to chronic cough in various national guidelines. However, the complexity of its pathogenesis, the lack of clarity surrounding its diagnostic criteria, and its overlap with other etiologies of chronic cough present considerable challenges in both diagnosis and ...
Wan‐Ting Huang, Jia Chen
wiley   +1 more source

Effects of Electrical Stimulation of the Dorsal Raphe Nucleus on Local Cerebral Blood Flow in the Rat

open access: yes, 1989
We have studied the effects of electrical stimulation of the dorsal raphe nucleus on local cerebral blood flow (LCBF), as assessed by the quantitative [14C]-iodoantipyrine autoradiographic technique.
G. Bonvento, J. Seylaz, P. Lacombe
core   +1 more source

Two major network domains in the dorsal raphe nucleus [PDF]

open access: yesJournal of Comparative Neurology, 2015
Serotonin neurons in the dorsal and median raphe nuclei (DR and MR) are clustered into heterogeneous groups that give rise to topographically organized forebrain projections. However, a compelling definition of the key subgroups of serotonin neurons within these areas has remained elusive.
openaire   +2 more sources

Is there a role for cannabidiol in obesity, metabolic syndrome and binge eating?

open access: yesBritish Journal of Pharmacology, EarlyView.
Cannabidiol (CBD) is one of the most abundant phytocannabinoids isolated from the Cannabis sativa plant. CBD is a lipophilic, non‐intoxicating substance that differently from Δ9‐tetrahydrocannabinol (Δ9‐THC) does not present the typical profile of a drug of abuse.
Luca Botticelli   +7 more
wiley   +1 more source

GABA release in the dorsal raphe nucleus: role in the control of REM sleep

open access: yes, 1997
The cessation of firing of serotonergic dorsal raphe neurons is a key controlling event of rapid eye movement (REM) sleep. We tested the hypothesis that this cessation of activity is due to gamma-aminobutyric acid (GABA) release using the in vivo ...
J. Siegel, D. Nitz
core   +1 more source

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