Results 61 to 70 of about 653,638 (208)

Dorsal raphe nucleus efferents: Termination in peptidergic fields

Peptides, 1993
This study was performed to identify the efferents of the dorsal raphe nucleus (DRN), particularly in regard to nociception. Phaseolus vulgaris leucoagglutinin (PHA-L) was microiontophoresed into the DRN and visualized immunocytochemically; PHA-L-immunoreactive (-IR) fibers and terminals were identified in the forebrain, hypothalamus, midline and ...
L J, Sim, S A, Joseph
openaire   +2 more sources

Underlying Mechanisms of the Treatment Efficacy of (R, S)‐Ketamine for Post‐Traumatic Stress Disorder and Depression: A Review

Medicine Advances
Numerous studies have demonstrated the efficacy of (R, S)‐ketamine as a treatment for post‐traumatic stress disorder (PTSD), treatment‐resistant depression, and comorbid occurrences of these conditions. The (R) and (S) stereoisomers of ketamine have also
Thomas Edward Cutting, Richard Evans Hartman   +1 more
doaj   +1 more source

The ongoing oleoylethanolamide story: Therapeutic implications in the control of obesity and its comorbidities

British Journal of Pharmacology, EarlyView.
The global burden of obesity continues to rise, demanding effective pharmacological strategies for individuals in whom prevention alone is insufficient. Recent incretin‐based and multi‐agonist therapies have delivered unprecedented weight loss, demonstrating that the simultaneous modulation of multiple metabolic pathways can optimize body weight ...
Marzia Friuli, Alessia Campagna, Barbara Eramo, Christian Sepe, Annarita Zuena, Silvana Gaetani, Adele Romano   +6 more
wiley   +1 more source

Participação de a-adrenoceptores do núcleo mediano da rafe no controle da resposta ingestiva em ratos saciados [PDF]

, 2014
Dissertação (mestrado) - Universidade Federal de Santa Catarina, Centro de Ciências Biológicas, Programa de Pós-Graduação em Neurociências, Florianópolis, 2014.O presente estudo avaliou a participação de a-adrenoceptores do núcleo mediano da rafe (NMR ...
Levone, Brunno Rocha
core  

Chronic insomnia, REM sleep instability and emotional dysregulation: A pathway to anxiety and depression?

Journal of Sleep Research, Volume 34, Issue 2, April 2025.
Summary The world‐wide prevalence of insomnia disorder reaches up to 10% of the adult population. Women are more often afflicted than men, and insomnia disorder is a risk factor for somatic and mental illness, especially depression and anxiety disorders.
Dieter Riemann, Raphael J. Dressle, Fee Benz, Kai Spiegelhalder, Anna F. Johann, Christoph Nissen, Elisabeth Hertenstein, Chiara Baglioni, Laura Palagini, Lukas Krone, Michael L. Perlis, Katharina Domschke, Mathias Berger, Bernd Feige   +13 more
wiley   +1 more source

Functional consequences of retinopetal fibers originating in the dorsal raphe nucleus

, 2008
The existence of centrifugal fibers projecting into the mammalian retina is well known. However, their precise physiological role is poorly understood.
Lorincz, M. L., Oláh, M., Juhász Gábor, Dénes   +2 more
core   +1 more source

Global reward state affects learning and activity in raphe nucleus and anterior insula in monkeys

Nature Communications, 2020
Wittmann and colleagues show that not only single outcome events but also the global reward state (GRS) impact learning in macaques; low GRS drives explorative choices.
Marco K. Wittmann, Elsa Fouragnan, Davide Folloni, Miriam C. Klein-Flügge, Bolton K. H. Chau, Mehdi Khamassi, Matthew F. S. Rushworth   +6 more
doaj   +1 more source

Effects of prucalopride on anxiety and depressive symptoms among constipated patients: A meta‐analysis of randomized controlled trials

Psychiatry and Clinical Neurosciences, EarlyView.
Aims Prucalopride, a 5‐HT4 receptor agonist, has shown potential for rapid anxiolytic and antidepressant effects in preclinical studies. This meta‐analysis aims to evaluate changes in anxiety and depressive symptoms after prucalopride treatment in chronically constipated adults.
Lucie Lebon, Denis J. David, Matthieu Gasnier, Indira Mendez‐David, Laurent Becquemont, Céline Verstuyft, René Hen, Emmanuelle Corruble, Romain Colle   +8 more
wiley   +1 more source

Intraocular co-grafts of fetal dorsal raphe nucleus and suprachiasmatic nucleus

Brain Research, 1993
Serotonergic neurons in the fetal dorsal raphe nucleus were grafted together with fetal anterior hypothalamic tissue including the suprachiasmatic nucleus (SCN) to the anterior eye chamber of adult rats. After 6 weeks transplantation, the double grafts were immunocytochemically examined using antisera against serotonin, arginine vasopressin (AVP) and ...
S, Ueda, Y, Matsumoto, E C, Azmitia, M, Kawata   +3 more
openaire   +2 more sources

Firing of 5-HT neurones in the dorsal and median raphe nucleus in vitro shows differential α₁-adrenoceptor and 5-HT_1A receptor modulation [PDF]

, 2005
The median raphe nucleus and dorsal raphe nucleus together are the major source of ascending 5-HT projections. Here, using in vitro extracellular single unit electrophysiology we examined the responses of individual neurones in the rat median raphe ...
Gartside SE, Judge SJ
core   +3 more sources