Results 31 to 40 of about 653,638 (208)

Adaptive Control of Dorsal Raphe by 5-HT4 in the Prefrontal Cortex Prevents Persistent Hypophagia following Stress

Cell Reports, 2017
Summary: Transient reduced food intake (hypophagia) following high stress could have beneficial effects on longevity, but paradoxically, hypophagia can persist and become anorexia-like behavior.
Alexandra Jean, Laetitia Laurent, Sabira Delaunay, Stéphane Doly, Nicole Dusticier, David Linden, Rachael Neve, Luc Maroteaux, André Nieoullon, Valérie Compan   +9 more
doaj   +1 more source

The possible mechanisms of analgesia produced by microinjection of morphine into the lateral habenula in the acute model of trigeminal pain in rats

Research in Pharmaceutical Sciences, 2017
This study aimed to assess the effect of intra-habenular injection of morphine on acute trigeminal pain in rats. Also here, we examined the involvement of raphe nucleus opioid and 5HT3 receptors on the antinociceptive activity of intra habenular morphine
Emad Khalilzadeh, Gholamreza Vafaei Saiah   +1 more
doaj   +1 more source

Afferent Projections to the Central Superior Raphe Nucleus of Brain Stem and Its Relation to Acupuncture Anesthesia

针刺研究, 1995
The afferent projections to the central superior raphe nuclus' (CS) in the rat were investigated bymeans of HRP retrograte tracting method. 3% WGA-HRP 0. 05-0. 1μl was injected into the CS ineach of 11 rats.
王继立, 范天生, 李世东
doaj   +2 more sources

Administration of the GABA_A receptor antagonist picrotoxin into rat supramammillary nucleus induces c-Fos in reward-related brain structures. Supramammillary picrotoxin and c-Fos expression

BMC Neuroscience, 2010
Background Picrotoxin blocks GABAA receptors, whose activation typically inhibits neuronal firing activity. We recently found that rats learn to selectively self-administer picrotoxin or bicuculline, another GABAA receptor antagonist, into the ...
Shin Rick, Ikemoto Satoshi
doaj   +1 more source

Serotonergic Neurons in the Chick Brainstem Express Various Serotonin Receptor Subfamily Genes

Frontiers in Physiology, 2022
Serotonin (5-hydroxytryptamine, 5-HT) is a phylogenetically conserved modulatory neurotransmitter. In mammals, 5-HT plays an important role in the regulation of many mental states and the processing of emotions in the central nervous system. Serotonergic
Toshiyuki Fujita, Naoya Aoki, Chihiro Mori, Eiko Fujita, Toshiya Matsushima, Koichi J. Homma, Shinji Yamaguchi   +6 more
doaj   +1 more source

Negative consequences of early-life adversity on substance use as mediated by corticotropin-releasing factor modulation of serotonin activity

Neurobiology of Stress, 2018
Early-life adversity is associated with increased risk for substance abuse in later life, with women more likely to report past and current stress as a mediating factor in their substance use and relapse as compared to men. Preclinical models of neonatal
Gina L. Forster, Eden M. Anderson, Jamie L. Scholl, Jodi L. Lukkes, Michael J. Watt   +4 more
doaj   +1 more source

The serotonergic neurons derived from rhombomere 2 are localized in the median raphe and project to the dorsal pallium in zebrafish

Neuroscience Research
The serotonergic neurons in the raphe nucleus are implicated in various cognitive functions such as learning and emotion. In vertebrates, the raphe nucleus is divided into the dorsal raphe and the median raphe.
Kotaro Shibayama, Haruna Nakajo, Yuki Tanimoto, Hisaya Kakinuma, Toshiyuki Shiraki, Takashi Tsuboi, Hitoshi Okamoto   +6 more
doaj   +1 more source

SCTR–Expressing Astrocyte–Serotonergic Neuron Signaling Drives Sexual Dimorphism in Depression Through KAT7/H4ac–Foxc2 Epigenetic Axis in an AMPK‐Dependent Manner

Advanced Science, EarlyView.
Astrocytic SCTR modulates depressive‐related phenotypes via AMPKα1, whereas lowered Mt1 blunts Megalin‐dependent AMPKα2 signaling in serotonergic neurons. Diminished AMPKα2 hinders KAT7 nuclear translocation, curtails KAT7 occupancy and H4K8ac at the Foxc2 promoter, and represses Foxc2 transcription, revealing cell‐type‐specific AMPK‐linked epigenetic ...
Fantao Meng, Jing Liu, Juanjuan Dai, Min Wu, Wentao Wang, Mengdi Zhang, Shujun Jiang, Yifan Cao, Lihong Xu, Lin Du, Dan Wang, Di Zhao, Gaofeng Qin, Dong Wang, Wei Li, Chen Li   +15 more
wiley   +1 more source

Propofol Modulates Fear Memory Reconsolidation by Inhibiting D2 Receptor‐Expressing Neurons in the Medial Prefrontal Cortex

Advanced Science, EarlyView.
This study shows that propofol modulates fear‐memory reconsolidation in mice. It works by suppressing D2 receptor‐expressing neurons within the medial prefrontal cortex and their connections to the basolateral amygdala. D2‐receptor agonists reproduce this fear‐reducing effect, offering potential non‐anesthetic therapeutic strategies for trauma‐related ...
Jie Li, Yi‐Ge Guo, Xing Xu, Gui‐Lin Meng, Han Li, Liu‐Wei Chu, Xin‐Yuan Chen, Xiao‐Yun Guo, Tao Xu, Ti‐Fei Yuan, Ji Hu, Xiao‐Na Zhu   +11 more
wiley   +1 more source

Tryptophan hydroxylase activity in rat brain base arteries related to innervation originating from the dorsal raphe nucleus.

, 1994
Tryptophan hydroxylase activity was assayed in cell-free extracts of rat brain base arteries as marker of a serotonergic innervation. Estimation of the enzymatic activity was made in untreated male Sprague-Dawley rats (n = 53) and in those who ...
E J Marco, M J Moreno, A L López de Pablo   +2 more
core   +1 more source