Results 61 to 70 of about 1,233,920 (254)

Vertebrate Sensory Ganglia: Common and Divergent Features of the Transcriptional Programs Generating Their Functional Specialization

Frontiers in Cell and Developmental Biology, 2020
Sensory fibers of the peripheral nervous system carry sensation from specific sense structures or use different tissues and organs as receptive fields, and convey this information to the central nervous system.
Simon Vermeiren, Eric J. Bellefroid, Simon Desiderio   +2 more
doaj   +1 more source

Protection against infection in dorsal root ganglia.

, 2013
A subset of the animals immunized as described in Fig. 3 was challenged intravaginally, as described in Fig. 4, 58 days after the last vaccine dose, and dorsal root ganglia were extracted 4 days post-challenge.
Patricia Londoño-Hayes (303085), John Catalan (303079), Simge Baloglu (303081), Stephen F. Anderson (303083), Mark Parrington (303086), Simon Delagrave (303074), Harry Kleanthous (303088), Hector Hernandez (303075), John F. Hamberger (303077), Changhong Zhou (303076), Joshua M. DiNapoli (303084), Jeffrey Almond (303087), Sophia T. Mundle (303078)   +12 more
core   +1 more source

Targeting CXCR2 in Nociceptive Sensory Neurons Offers Novel Therapeutic Potentials for Postoperative Pain

Advanced Science, EarlyView.
Tissue incision induces CXCL5 release, which activates neuronal CXCR2 on incision‐innervating sensory neurons. Neuronal CXCR2 couples with TRPA1 to drive mechanical pain and engages p38 MAPK signaling to upregulate TRPV1 and promote heat pain. Targeted Cxcr2 knockdown relieves incisional pain while preserving CXCR2‐dependent neutrophil responses ...
Yushuang Pan, Peiyi Li, Yufeng Chen, Zishan Dong, Yuanyuan Li, Boyu Liu, Yan Tai, Chuan Wang, Jianqiao Fang, Chengyu Yin, Boyi Liu   +10 more
wiley   +1 more source

Impacts of anti-nerve growth factor antibody on pain-related behaviors and expressions of opioid receptor in spinal dorsal horn and dorsal root ganglia of rats with cancer-induced bone pain

Molecular Pain, 2016
Objective To investigate the impacts of anti-nerve growth factor antibody on pain-related behaviors and expressions of μ-opioid receptor in spinal dorsal horn and dorsal root ganglia of rats with cancer-induced bone pain.
Peng Yao MD, PhD, Yuanyuan Ding MD, Zhibin Wang MD, Jiaming Ma MM, Tao Hong MM, Yongqiang Zhu MM, Hongxi Li MM, Shinong Pan MD, PhD   +7 more
doaj   +1 more source

Microencapsulation improves inhibitory effects of transplanted olfactory ensheathing cells on pain after sciatic nerve injury

Neural Regeneration Research, 2015
Olfactory bulb tissue transplantation inhibits P2X2/3 receptor-mediated neuropathic pain. However, the olfactory bulb has a complex cellular composition, and the mechanism underlying the action of purified transplanted olfactory ensheathing cells (OECs ...
Hao Zhao, Bao-lin Yang, Zeng-xu Liu, Qing Yu, Wen-jun Zhang, Keng Yuan, Hui-hong Zeng, Gao-chun Zhu, De-ming Liu, Qing Li   +9 more
doaj   +1 more source

Regulating Cells Fate and Function to Facilitate Bone Regeneration via Designing Programmable Bio‐Interactive Materials

Advanced Science, EarlyView.
This article aims to elucidate the biological mechanisms of bone repair and the evolution of material design, highlighting key cellular and molecular processes. It further proposes strategies and prospects for programmable bio‐interactive materials, which enable precisely guided bone tissue regeneration by dynamically regulating cell behavior and the ...
Qingrui Fan, Fuming Cao, Junqiang Mao, Pengbin Yin, Licheng Zhang, Jianjun Wang, Peifu Tang   +6 more
wiley   +1 more source

Dorsal root ganglion macrophages contribute to both the initiation and persistence of neuropathic pain

Nature Communications, 2020
Interactions among spinal dorsal horn neurons and microglia contribute to the induction and maintenance of neuropathic pain after peripheral nerve injury.
Xiaobing Yu, Hongju Liu, Katherine A. Hamel, Maelig G. Morvan, Stephen Yu, Jacqueline Leff, Zhonghui Guan, Joao M. Braz, Allan I. Basbaum   +8 more
doaj   +1 more source

An Innervated Human Skin Equivalent that Electrically Encodes Mechanical and Thermal Stimuli

Advanced Science, EarlyView.
An innervated human skin equivalent is integrated with high‐density microelectrode arrays to reveal how engineered free nerve ending–like structures translate touch and temperature into electrical codes. Mechanical indentation and thermal stimulation engage the engineered somatosensory circuitry and evoke distinct firing and waveform signatures ...
Daniele Bellantoni, Costantino Casale, Marika Sperduti, Nevio L. Tagliamonte, Giorgia Imparato, Loredana Zollo, Paolo A. Netti   +6 more
wiley   +1 more source

Phospholipase C gamma mediates endogenous brain-derived neurotrophic factor-regulated calcitonin gene-related peptide expression in colitis-induced visceral pain

Molecular Pain, 2016
Background Visceral hypersensitivity is a complex pathophysiological paradigm with unclear mechanisms. Primary afferent neuronal plasticity marked by alterations in neuroactive compounds such as calcitonin gene-related peptide is suggested to underlie ...
Fiza Hashmi MS, Miao Liu PhD, Shanwei Shen MS, Li-Ya Qiao PhD   +3 more
doaj   +1 more source

AXL signaling in primary sensory neurons contributes to chronic compression of dorsal root ganglion-induced neuropathic pain in rats

Molecular Pain, 2020
Low back pain is a chronic, highly prevalent, and hard-to-treat condition in the elderly. Clinical studies indicate that AXL, which belongs to the tyrosine kinase receptor subfamily, mediates pathological pain.
Lingli Liang, Jun Zhang, Lixia Tian, Shuo Wang, Linping Xu, Yingxuan Wang, Qingying Guo-Shuai, Yue Dong, Yu Chen, Hong Jia, Xuewei Yang, Chunmei Yuan   +11 more
doaj   +1 more source