Results 51 to 60 of about 1,237,495 (192)

An organized 3D in vitro model for peripheral nerve studies [PDF]

, 2013
Three-dimensional cell cultures have been proposed to address the limitations in two-dimensional cell cultures (i.e. lack of relevant architectural features) and very few have developed 3D cell culture methods for peripheral nerve studies. Therefore, the
Daud, Muhammad Fauzi
core   +4 more sources

Sonoporation-mediated gene transfer into adult rat dorsal root ganglion cells

Journal of Biomedical Science, 2010
Background Gene transfer into many cell types has been successfully used to develop alternative and adjunct approaches to conventional medical treatment. However, effective transfection of postmitotic neurons remains a challenge.
Wu Chih-Hsien, Sheen-Chen Shyr-Ming, Cheng Jiin-Tsuey, Yang Chien-Hui, Chen Kuan-Hung, Lin Chung-Ren, Sy Wei-Dih, Chen Yi-Shen   +7 more
doaj   +1 more source

Activation of STAT3-mediated CXCL12 up-regulation in the dorsal root ganglion contributes to oxaliplatin-induced chronic pain

Molecular Pain, 2017
Oxaliplatin-induced chronic painful neuropathy is the most common dose-limiting adverse event that negatively affects cancer patients’ quality of life. However, the underlying molecular mechanisms are still unclear.
Yong-Yong Li, He Li, Ze-Long Liu, Qiong Li, Hua-Wen Qiu, Li-Jin Zeng, Wen Yang, Xiang-Zhong Zhang, Zhen-Yu Li   +8 more
doaj   +1 more source

Altered expression of the voltage-gated calcium channel subunit α2δ-1: a comparison between two experimental models of epilepsy and a sensory nerve ligation model of neuropathic pain. [PDF]

, 2014
The auxiliary α2δ-1 subunit of voltage-gated calcium channels is up-regulated in dorsal root ganglion neurons following peripheral somatosensory nerve damage, in several animal models of neuropathic pain.
Sandhu, G, Bauer, CS, Dolphin, AC, Jiruska, P., Jefferys, J.G.R., Nieto-Rostro, M., Sandhu, G., Dolphin, A.C., Bauer, C.S., Jiruska, P, Nieto-Rostro, M, Jefferys, JG   +11 more
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Dorsal root ganglion – a potential new therapeutic target for neuropathic pain

, 2012
Damir Sapunar, Sandra Kostic, Adriana Banozic, Livia PuljakDepartment of Anatomy, Histology, and Embryology, University of Split Medical School, Soltanska 2, 21000 Split, CroatiaAbstract: A regional approach can protect our patients from often ...
Banozic A, Puljak L, Kostic S, Sapunar D
core  

FMI-43 is a permeant blocker of mechanosensitive ion channels in sensory neurons and inhibits behavioural responses to mechanical stimuli [PDF]

, 2007
The molecular identity and pharmacological properties of mechanically gated ion channels in sensory neurons are poorly understood. We show that FM1-43, a styryl dye used to fluorescently label cell membranes, permeates mechanosensitive ion channels in ...
Wood John N, Wood, John, Drew, LJ, Drew, Liam, Liam J Drew, John N Wood, Wood, JN, Drew Liam J   +7 more
core   +1 more source

Neurosarcoidosis with enlargement of the dorsal root ganglia: A case report

Radiology Case Reports
We report the case of a woman in her 40s who presented with sensory disturbances in all 4 limbs and left facial palsy. MRI revealed asymmetric enlargement of the dorsal root ganglia, which was enhanced by gadolinium—a chest CT scan identified enlarged ...
Sakie Namba, Hajime Yokota, Hiroki Mukai, Jun Hashiba, Naoki Kogayo, Tatsushi Nakao, Atsuhiko Sugiyama, Etsuko Ogaya, Yuya Aotsuka, Satoshi Kuwabara, Takashi Uno   +10 more
doaj   +1 more source

The stress protein heat shock cognate 70 (Hsc70) inhibits the Transient Receptor Potential Vanilloid type 1 (TRPV1) channel

Molecular Pain, 2016
Background Specialized cellular defense mechanisms prevent damage from chemical, biological, and physical hazards. The heat shock proteins have been recognized as key chaperones that maintain cell survival against a variety of exogenous and endogenous ...
Mircea Iftinca PhD, Robyn Flynn PhD, Lilian Basso PhD, Helvira Melo PhD, Reem Aboushousha MSc, Lauren Taylor BSc, Christophe Altier PhD   +6 more
doaj   +1 more source

Involvement of NIPSNAP1, a neuropeptide nocistatin-interacting protein, in inflammatory pain

Molecular Pain, 2016
Background Chronic pain associated with inflammation is an important clinical problem, and the underlying mechanisms remain poorly understood. 4-Nitrophenylphosphatase domain and nonneuronal SNAP25-like protein homolog (NIPSNAP) 1, an interacting protein
Kazuya Okamoto ME, Masaki Ohashi BE, Kana Ohno BE, Arisa Takeuchi BE, Etsuko Matsuoka BE, Kyohei Fujisato BE, Toshiaki Minami MD, PhD, Seiji Ito MD, PhD, Emiko Okuda-Ashitaka PhD   +8 more
doaj   +1 more source

Bulleyaconitine A attenuates hyperexcitability of dorsal root ganglion neurons induced by spared nerve injury: The role of preferably blocking Nav1.7 and Nav1.3 channels

Molecular Pain, 2018
Background Oral administration of Bulleyaconitine A, an extracted diterpenoid alkaloid from Aconitum bulleyanum plants, is effective for treating chronic pain in rats and in human patients, but the underlying mechanisms are poorly understood.
Man-Xiu Xie, Jie Yang, Rui-Ping Pang, Wei-An Zeng, Han-Dong Ouyang, Yan-Qing Liu, Xian-Guo Liu   +6 more
doaj   +1 more source