Results 31 to 40 of about 1,237,495 (192)

One-cell model for inhibiting Cav3.3 mRNA expression by RNA interference

Biotechnology & Biotechnological Equipment, 2017
To gain insights into the function of Cav3.3 T-type calcium channel in dorsal root ganglion neurons, we designed a one-cell model in dorsal root ganglion neurons that specifically inhibits the expression of Cav3.3 mRNA.
Xiaohong Li, Changzheng Peng, Xiaoping Wang, Xianjie Wen   +3 more
doaj   +1 more source

Anatomical study on the relationship between the dorsal root ganglion and the intervertebral disc in the lumbar spine

Revista Brasileira de Ortopedia, 2015
OBJECTIVE: To describe the location of the dorsal root ganglion in relation to the intervertebral disc, including the "triangular" safety zone for minimally invasive surgery in the lumbar spine. METHODS: Eight adult cadavers were dissected bilaterally in
Emiliano Vialle, Luiz Roberto Vialle, William Contreras, Chárbel Jacob Junior   +3 more
doaj   +1 more source

Intrathecal liproxstatin-1 delivery inhibits ferroptosis and attenuates mechanical and thermal hypersensitivities in rats with complete Freund’s adjuvant-induced inflammatory pain

Neural Regeneration Research, 2023
Previous studies have confirmed the relationship between iron-dependent ferroptosis and a peripheral nerve injury-induced neuropathic pain model. However, the role of ferroptosis in inflammatory pain remains inconclusive.
Yi-Fan Deng, Ping Xiang, Jing-Yi Du, Jian-Fen Liang, Xiang Li   +4 more
doaj   +1 more source

Upregulation of CX3CL1 mediated by NF-κB activation in dorsal root ganglion contributes to peripheral sensitization and chronic pain induced by oxaliplatin administration

Molecular Pain, 2017
Painful peripheral neuropathy is a severe side effect in oxaliplatin therapy that compromises cancer patients' quality of life. However, its underlying pathogenic mechanisms remain largely unknown.
Jing Wang, Xin-Sheng Zhang, Rong Tao, Jie Zhang, Lin Liu, Ying-Hai Jiang, Song-He Ma, Lin-Xia Song, Ling-Jie Xia   +8 more
doaj   +1 more source

Rapid Isolation of Dorsal Root Ganglion Macrophages [PDF]

Journal of Visualized Experiments, 2019
There are growing interests to study the molecular and cellular interactions among immune cells and sensory neurons in the dorsal root ganglia after peripheral nerve injury. Peripheral monocytic cells, including macrophages, are known to respond to a tissue injury through phagocytosis, antigen presentation, and cytokine release.
Yu, Xiaobing, Leff, Jacqueline, Guan, Zhonghui   +2 more
openaire   +4 more sources

Antinociceptive effectiveness of the inhibition of NCX reverse-mode action in rodent neuropathic pain model

Molecular Pain, 2019
Background Chronic neuropathic pain is a debilitating condition that remains difficult to treat. The Na + -Ca 2+ exchanger (NCX) is a transporter that can exchange Ca 2+ with Na + in either direction to maintain intracellular Ca 2+ homeostasis.
Yang Huang, Li-Li Wen, Jing-Dun Xie, Han-Dong Ouyang, Dong-Tai Chen, Wei-An Zeng   +5 more
doaj   +1 more source

Activation of neurons and satellite glial cells in the DRG produces morphine-induced hyperalgesia

Molecular Pain, 2023
Activation of neurons and glial cells in the dorsal root ganglion is one of the key mechanisms for the development of hyperalgesia. The aim of the present study was to examine the role of neuroglial activity in the development of opioid-induced ...
Shunsuke Yamakita, Daisuke Fujita, Kazuki Sudo, Daiki Ishikawa, Kohsuke Kushimoto, Yasuhiko Horii, Fumimasa Amaya   +6 more
doaj   +1 more source

The Upregulation of α2δ-1 Subunit Modulates Activity-Dependent Ca2+ Signals in Sensory Neurons. [PDF]

, 2015
As auxiliary subunits of voltage-gated Ca(2+) channels, the α2δ proteins modulate membrane trafficking of the channels and their localization to specific presynaptic sites.
Margas, W, Dolphin, AC, D'Arco, M, Cassidy, JS   +3 more
core  

Mechanism of persistent hyperalgesia in neuropathic pain caused by chronic constriction injury

Neural Regeneration Research, 2019
Transmembrane member 16A (TMEM16A) is involved in many physiological functions, such as epithelial secretion, sensory conduction, nociception, control of neuronal excitability, and regulation of smooth muscle contraction, and may be important in ...
Qin-Yi Chen, Chao-Yang Tan, Yang Wang, Ke-Tao Ma, Li Li, Jun-Qiang Si   +5 more
doaj   +1 more source

Upregulation of bone morphogenetic protein 2 () in dorsal root ganglion in a rat model of bone cancer pain

Molecular Pain, 2019
Bone cancer pain is one of the most severe and intractable complications in patients suffering from primary or metastatic bone cancer and profoundly compromises the quality of life.
Wei Wang, Qiliang Jiang, Jingxiang Wu, Wei Tang, Meiying Xu   +4 more
doaj   +1 more source