Results 11 to 20 of about 1,237,495 (192)
Lu Hua,1,2,* Kaiyuan Sha,1,2,* HongCheng Lu,1,2 Ying Han,1,2 Cehua Ou,1,2 Jiang-Lin Wang,1 Yue Zhang1,2 1Department of Pain Management, The Affiliated Hospital of Southwest Medical University, Luzhou, People’s Republic of China; 2Anesthesiology ...
Hua L +6 more
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Eve Peeraer1,2, An Van Lutsenborg3, An Verheyen1,4, Raf De Jongh5, Rony Nuydens1, Theo F Meert1,21Johnson & Johnson Pharmaceutical Research and Development, Beerse, Belgium; 2University Hasselt, Hasselt, Belgium; 3Free University Brussels ...
Eve Peeraer +3 more
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Evaluation of AAV8 as a gene therapy vector to deliver NT-3 and shRNA\(_{RhoA}\) to injured dorsal root ganglion neurones [PDF]
Two major reasons for the failure of central nervous system axon regeneration are (i) lack of neurotrophic factors available to CNS neurones and (ii) the presence of molecules that inhibit the growth of axons. In this study a gene therapy approach using
Jacques, Steven John
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Expression of neuropeptides – galanin and Reg2 - in subcategories of nociceptors after nerve injury [PDF]
PhDNeuropeptides show dynamic changes in expression after nerve injury, and have been implicated in chronic pain states. I sought to compare expression of two peptides which are upregulated after nerve injury, galanin and Reg2, and to determine the ...
Burrows, Karen Lynne
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Mechanisms involved in chronic neuropathic pain after avulsion injury [PDF]
PhDMotor vehicle accidents are the most common cause of injuries involving avulsion of spinal roots from the brachial or lumbosacral plexuses. This results in chronic intractable pain that is refractory to pharmacotherapy.
Chew, Daniel John
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Developmental changes in voltage-gated calcium channel α(2)δ-subunit expression in the canine dorsal root ganglion [PDF]
The voltage-gated calcium channel subunit (128 plays a fundamental role in propagation of excitatory signals associated with release of glutamate and neuropeptides substance P (SP) and calcitonin gene-related protein (CGRP).
K. Matiasek +18 more
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Intense isolectin-B4 binding in rat dorsal root ganglion neurons distinguishes c-fiber nociceptors with broad action potentials and high nav1.9 expression [PDF]
Binding to isolectin-B4 (IB4) and expression of tyrosine kinase A (trkA) (the high-affinity NGF receptor) have been used to define two different subgroups of nociceptive small dorsal root ganglion (DRG) neurons. We previously showed that only nociceptors
Fang, Xin, Dr. +17 more
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Regulation of boundary cap neural crest stem cell differentiation after transplantation [PDF]
Success of cell replacement therapies for neurological disorders will depend largely on the optimization of strategies to enhance viability and control the developmental fate of stem cells after transplantation.
Hjerling-Leffler, J +19 more
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Chemical calcium indicators have been commonly used to monitor calcium (Ca 2+ ) activity in cell bodies, i.e., somata, of isolated dorsal root ganglion neurons.
Yong Chen, Li-Yen M Huang
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Ion channels are very important in the peripheral sensitization in neuropathic pain. Our present study aims to investigate the possible contribution of Ca V 3.2 T-type calcium channels in damaged dorsal root ganglion neurons in neuropathic pain.
Xue-Jing Kang +7 more
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