Results 1 to 10 of about 1,237,495 (192)

Voltage-gated sodium channel, Nav 1.8, regulates calcium dynamics in the dorsal root ganglion induced by cold nociceptive stimulus. [PDF]

PLoS ONE
Nociceptive pain responses are mediated by neurons in the dorsal root ganglion. Certain voltage-gated sodium channels, such as Nav 1.8, are necessary for action potential firing and sensing pain.
Moushumi Rani Dey, Baolin Li, John Heddleston, Eitaro Aihara   +3 more
doaj   +2 more sources

Neurobiology of the trigeminal ganglion in comparison to the dorsal root ganglion. [PDF]

Pain
Abstract The trigeminal ganglion (TG) represents the craniofacial counterpart of the dorsal root ganglion (DRG) in the peripheral nervous system (PNS). TG and DRG are clusters of cell bodies of highly specialized sensory neurons, with TG neurons innervating the head and face and DRG neurons innervating the body. TG and DRG neurons are
Su S, Kim M, Liedtke W, Chen Y.
europepmc   +2 more sources

The upregulation of EGFR in the dorsal root ganglion contributes to chronic compression of dorsal root ganglions-induced neuropathic pain in rats

Molecular Pain, 2019
The epidermal growth factor receptor (EGFR) located in dorsal root ganglion has been found as a new target for chronic pain treatment. However, it is not clear whether the change of EGFR expression in the dorsal root ganglion contributes to neuropathic ...
Shuo Wang, Siyi Liu, Linping Xu, Xuan Zhu, Wanyuan Liu, Lixia Tian, Yu Chen, Yuying Wang, Borra V Padma Nagendra, Shushan Jia, Lingli Liang, Fu-Quan Huo   +11 more
doaj   +2 more sources

Coccydynia Treated with Dorsal Root Ganglion Stimulation [PDF]

Case Reports in Anesthesiology, 2018
Coccydynia can be difficult to resolve with conventional treatment options. Dorsal root ganglion (DRG) stimulation has recently emerged as a treatment for chronic pain, but its application has not been described in the context of coccydynia.
Nicholas L. Giordano, Noud van Helmond, Kenneth B. Chapman   +2 more
doaj   +4 more sources

Rolipram, a Selective Phosphodiesterase 4 Inhibitor, Ameliorates Mechanical Hyperalgesia in a Rat Model of Chemotherapy-Induced Neuropathic Pain through Inhibition of Inflammatory Cytokines in the Dorsal Root Ganglion

Frontiers in Pharmacology, 2017
Chemotherapy-induced neuropathic pain is a significant side effect of chemotherapeutic agents and is the most common reason for stopping chemotherapy. The aim of the present study was to find the major site and mechanisms of action by which rolipram, a ...
Hee Kee Kim, Seon-Hee Hwang, Elizabeth Oh, Salahadin Abdi   +3 more
doaj   +1 more source

Expression and effect of sodium-potassium-chloride cotransporter on dorsal root ganglion neurons in a rat model of chronic constriction injury

Neural Regeneration Research, 2020
Sodium-potassium-chloride cotransporter 1 (NKCC1) and potassium-chloride cotransporter 2 (KCC2) are associated with the transmission of peripheral pain.
Chao-Yang Tan, Yan-Ping Wang, Yuan-Yuan Han, Bi-Han Lu, Wei Ji, Li-Cang Zhu, Yang Wang, Wen-Yan Shi, Li-Ya Shan, Liang Zhang, Ke-Tao Ma, Li Li, Jun-Qiang Si   +12 more
doaj   +1 more source

Two isoforms of cyclic GMP-dependent kinase-I exhibit distinct expression patterns in the adult mouse dorsal root ganglion

Molecular Pain, 2018
cGMP-dependent kinase-I (cGKI) is known to regulate spinal pain processing. This enzyme consists of two isoforms (cGKIα and cGKIβ) that show distinct substrate specificity and tissue distribution.
Hitoshi Uchida, Shinji Matsumura, Tayo Katano, Masahiko Watanabe, Jens Schlossmann, Seiji Ito   +5 more
doaj   +1 more source

Transcriptional regulatory network during axonal regeneration of dorsal root ganglion neurons: laser-capture microdissection and deep sequencing

Neural Regeneration Research, 2023
The key regulators and regeneration-associated genes involved in axonal regeneration of neurons after injury have not been clarified. In high-throughput sequencing, various factors influence the final sequencing results, including the number and size of ...
Li-Li Zhao, Tao Zhang, Wei-Xiao Huang, Ting-Ting Guo, Xiao-Song Gu   +4 more
doaj   +1 more source

Increased Na1.7 expression in the dorsal root ganglion contributes to pain hypersensitivity after plantar incision in rats

Molecular Pain, 2018
Postoperative pain remains a complex problem that is difficult to manage in the clinical context, seriously affecting rehabilitation and the quality of life of patients after surgery.
Jiaoli Sun, Ningbo Li, Guangyou Duan, Yi Liu, Shanna Guo, Cong Wang, Changmao Zhu, Xianwei Zhang   +7 more
doaj   +1 more source

Chronic cervical radiculopathic pain is associated with increased excitability and hyperpolarization-activated current () in large-diameter dorsal root ganglion neurons

Molecular Pain, 2017
Cervical radiculopathic pain is a very common symptom that may occur with cervical spondylosis. Mechanical allodynia is often associated with cervical radiculopathic pain and is inadequately treated with current therapies. However, the precise mechanisms
Da-Lu Liu, Xu Wang, Wen-Guang Chu, Na Lu, Wen-Juan Han, Yi-Kang Du, San-Jue Hu, Zhan-Tao Bai, Sheng-Xi Wu, Rou-Gang Xie, Ceng Luo   +10 more
doaj   +1 more source