Results 111 to 120 of about 523,044 (279)

Neurofilament Light Chain and Mutant Huntingtin Across Huntington's Disease Integrated Staging System Stages in Huntington Disease: A Cross‐Sectional Multimodal Analysis

Movement Disorders, EarlyView.
Abstract Background The Huntington's Disease Integrated Staging System (HD‐ISS) provides a framework for staging HD but does not incorporate fluid biomarkers. Objective The aim of this study was to examine neurofilament light chain (NfL) and mutant huntingtin (mHTT) and total tau across HD‐ISS stages and their associations with genetic burden ...
Jesús Pérez‐Pérez, Gonzalo Olmedo‐Saura, Arnau Puig Davi, Rocío Pérez González, Jordi Pegueroles, Andrea Horta‐Barba, Anna Vázquez Oliver, Elisa Rivas Asensio, Daniel Alcolea, Juan Fortea, Marina Guasch‐Jiménez, Tomas Xuclà Ferrarons, Frederic Sampedro Santaló, Lidia Bojtos, Óscar López‐Lombardía, Ignacio Aracil‐Bolaños, Berta Pascual‐Sedano, Carla Franch Martí, Laura Pérez Carasol, Margarita Rubio Romera, Yi Ji, Alexandre Gironell, Antonia Campolongo, Raul Martínez‐Fernández, Alberto Lleó, Javier Pagonabarraga, Saul Martínez‐Horta, Jaime Kulisevsky, BCN‐HD Working Group;, HDClarity investigators, Jesús Pérez‐Pérez, Gonzalo Olmedo‐Saura, Saül Martínez‐Horta, Arnau Puig‐Davi, Carla Franch, Paula Arranz‐Horno, Oscar López‐Lombardía, Lidia Bojtos, Antonia Campolongo, Javier Pagonabarraga, Jaime Kulisevsky, Asunción Ávila, Nuria Caballol, Alejandro Peral, Jesús Ruíz‐Idiago, Misericordia Floriach, Matilde Calopa, Helena Bejr Kasem, Clara Marzal Espí, Esteban Muñoz, Celia Painous, Irene Navalpotro, Victor Puente, Victoria González, Pau Pastor, Dolores Vilas, Iñigo Ruiz Barrio, Lourdes Ispierto, Eliot Gómez‐López, Claustre Pons, Gracia Pons, Maria Teresa Buongiorno, Anna Mas, Maria Pilar Gil, Jordi Casanovas, Edward Wild, Tiago Mestre, Mark Guttman, Philippe Rizek, Blair Leavitt, Carsten Saft, Bjorn Falkenburger, Juergen Winkler, Ralf Reilmann, Jan Lewerenz, Alzbeta Mühlbäck, Jesús Pérez‐Pérez, Tamara Fernandez Valle, José Luis López‐Sendón Moreno, Christophe Verny, Cyril Goizet, Caterina Mariotti, Ferdinando Squitieri, Tim Anderson, Richard Roxburgh, Grzegorz Witkowski, Leonor Correia Guedes, Hugh Rickards, Elizabeth Coulthard, Roger Barker, Anne Rosser, Tim Harrower, Robert Thompson, James Herron, Jeremy Cosgrove, Rhys Davies, Nayana Lahiri, Richard Armstrong, Daniel Lashley, Jee Bang, Erin Furr‐Stimming, Jessica Tate, Meagen Salinas, Karen Anderson, Amy Brown   +104 more
wiley   +1 more source

Evaluating the Role of the Dorsolateral Prefrontal Cortex and Posterior Parietal Cortex in Memory-Guided Attention With Repetitive Transcranial Magnetic Stimulation

Frontiers in Human Neuroscience, 2018
The contents of working memory (WM) can affect the subsequent visual search performance, resulting in either beneficial or cost effects, when the visual search target is included in or spatially dissociated from the memorized contents, respectively.
Min Wang, Ping Yang, Chaoyang Wan, Zhenlan Jin, Junjun Zhang, Ling Li   +5 more
doaj   +1 more source

Dorsolateral Prefrontal Cortex Enables Updating of Established Memories

Cerebral Cortex, 2018
Abstract Updating established memories in light of new information is fundamental for memory to guide future behavior. However, little is known about the brain mechanisms by which existing memories can be updated. Here, we combined functional magnetic resonance imaging and multivariate representational similarity analysis to elucidate ...
Lisa Marieke, Kluen, Lisa Catherine, Dandolo, Gerhard, Jocham, Lars, Schwabe   +3 more
openaire   +2 more sources

Effects of Orbitofrontal Cortex tDCS on Cognitive Control in Individuals With Obesity: A Randomized Sham‐Controlled Trial

Obesity, EarlyView.
ABSTRACT Objective Neurocognitive traits can drive obesity‐related eating behaviors. The orbitofrontal cortex (OFC) integrates reward and sensory information to guide food‐related decision‐making. Here, we build on prior data in individuals without obesity demonstrating that transcranial direct current stimulation (tDCS) of the OFC improves cognitive ...
Jessica Ruffolo, Alexander McGirr, Stephanie L. Borgland   +2 more
wiley   +1 more source

The dual incretin agonist tirzepatide blunts nicotine‐induced behaviours and neurochemistry in male mice

British Journal of Pharmacology, EarlyView.
Abstract Background and Purpose Nicotine dependence remains one of the leading causes of morbidity and mortality worldwide, with high relapse rates and post‐cessation weight gain representing persistent barriers to sustained abstinence. The incretin hormones glucose‐dependent insulinotropic polypeptide (GIP) and glucagon‐like peptide‐1 (GLP‐1) have ...
Christian E. Edvardsson, Thaynnam A. Emous, Sarah Witley, Mia Ericson, Louise Adermark, Elisabet Jerlhag   +5 more
wiley   +1 more source

The relationship between grip strength, 6 minute walking distance and working memory in older adults with mild cognitive impairment: an fNIRS study

BMC Geriatrics
Objective Functional near-infrared spectroscopy (fNIRS) was employed to explore the potential relationship between grip strength, 6-minute walking distance (6MWD), and working memory in older adults with mild cognitive impairment (MCI).
Peng Wang, Yanran Si, Zhidong Cai, Wanting Jiang, Xin Xin, Shufan Li, Shuqi Jia, Qing Liu, Xing Wang   +8 more
doaj   +1 more source

Performance- and stimulus-dependent oscillations in monkey prefrontal cortex during short-term memory [PDF]

, 2009
Short-term memory requires the coordination of sub-processes like encoding, retention, retrieval and comparison of stored material to subsequent input. Neuronal oscillations have an inherent time structure, can effectively coordinate synaptic integration
Rodriguez, E.F., Pipa, Gordon, Munk, M.H.J., Rodriguez, Eugenio F., Munk, Matthias Hans Joachim, Waltz, James A., Muckli, Lars, Waltz, J.A., Städtler, E.S., Waltz, J., Pipa, G., Muckli, L.F., Munk, M.H., Muckli, L., Städtler, E., Rodriguez , E., Singer, Wolf, Munk, M., Städtler, Ellen, Singer, W., Goebel, R., Goebel, Rainer, Goebel, R.; id_orcid, Wolf Singer, Rainer Goebel, Lars Muckli, Gordon Pipa, James A Waltz, Ellen S Staedtler, Eugenio F Rodriguez, Matthias H J Munk   +30 more
core   +1 more source

A novel sequential bilateral neurostimulation approach for treatment-resistant depression involving high-frequency repetitive transcranial magnetic stimulation to the left dorsolateral prefrontal cortex and intermittent theta burst to the right dorsolateral prefrontal cortex

Brain Stimulation, 2023
Sabrina K. Segal, Charles L. Weber, Alexander M. Kaplan, Narin Wongngamnit, Aaron G. Avallone, Kartiki U. Churi, Andrew D. Davalt, Christopher G. Ivany   +7 more
doaj   +1 more source

Cooperation of the anterior cingulate cortex and dorsolateral prefrontal cortex for attention shifting

NeuroImage, 2004
Attention shifting in the working memory system plays an important role in goal-oriented behavior, such as reading, reasoning, and driving, because it involves several cognitive processes. This study identified brain activity leading to individual differences in attention shifting for dual-task performance by using the group comparison approach.
Hirohito M. Kondo, Naoyuki Osaka, Mariko Osaka   +2 more
openaire   +3 more sources

Energetic dysregulations in psychotic disorders: Targets for new therapeutics

The FEBS Journal, EarlyView.
The present review synthesizes literature documenting aberrant energy production and use, specifically related to mitochondrial and redox dysregulation, in psychotic disorders. Findings from different levels of investigation—genetic, cellular, and in vivo imaging—converge on aberrant energy metabolism as a hallmark of psychotic disorders.
Jacey Anderson, Kai‐Christian Sonntag, Thao Do Vy Le, Kaitlin Shannon, Chao Wang, Fei Du, Xi Chen, Donna McPhie, Dost Ongur, Bruce Cohen, Virginie‐Anne Chouinard   +10 more
wiley   +1 more source