Results 31 to 40 of about 435,529 (296)

The representation of abstract task rules in the human prefrontal cortex [PDF]

, 2009
We have previously reported sustained activation in the ventral prefrontal cortex while participants prepared to perform 1 of 2 tasks as instructed.
Haynes, J., Sakai, K., Sara L. Bengtsson, Sakai, K, Buckley, M., Buckley, Mark J., Passingham, Richard E., Passingham, RE, Passingham, Richard, Bengtsson, S. L., John-dylan Haynes, Bengtsson, S., Buckley, Mark, Sakai, Katsuyuki, Haynes, John-Dylan, Buckley, M.J., Buckley, MJ, Bengtsson, Sara L., Richard E. Passingham, Haynes, J.-D., Passingham, R., Passingham, R.E., Bengtsson, SL, Mark J. Buckley, Katsuyuki Sakai, Haynes, JD   +25 more
core   +1 more source

Prefrontal cortex contributions to controlled memory judgment : fMRI evidence from adolescents and young adults [PDF]

, 2012
Cortical regions supporting cognitive control and memory judgment are structurally immature in adolescents. Here we studied adolescents (13-15 y.o.) and young adults (20-22 y.o.) using a recognition memory paradigm that modulates cognitive control ...
Dobbins, Ian, O'Connor, Akira Robert, Jaeger, Antonio, Selmeczy, Diana, Diaz, Michael   +4 more
core   +1 more source

TULP4, a novel E3 ligase gene, participates in neuronal migration as a candidate in schizophrenia

CNS Neuroscience &Therapeutics, EarlyView., 2023
Mutations identified from four SCZ pedigrees resulted in decreased TULP4 expression. Tulp4 knockdown caused delayed neuron migration in embryonic mice, and impaired cognition and prepulse inhibition in adult mice. These phenotypes may be related to TULP4 through its involvement in the formation of a novel E3 ubiquitin ligases.
Yan Bi, Decheng Ren, Fan Yuan, Zhou Zhang, Daizhan Zhou, Xin Yi, Lei Ji, Keyi Li, Fengping Yang, Xi Wu, Xingwang Li, Yifeng Xu, Yun Liu, Peng Wang, Changqun Cai, Chuanxin Liu, Qian Ma, Lin He, Yi Shi, Guang He   +19 more
wiley   +1 more source

Prefrontal involvement in imitation learning of hand actions : effects of practice and expertise. [PDF]

, 2007
In this event-related fMRI study, we demonstrate the effects of a single session of practising configural hand actions (guitar chords) on cortical activations during observation, motor preparation, and imitative execution.
Canessa, Nicola, Rizzolatti, Giacomo, Freund, Hans-Joachim, Eickhoff, Simon B., Wohlschläger, Afra M., Shah, N. Jon, Fink, Gereon R., Buccino, Giovanni, Zilles, Karl, Vogt, Stefan   +9 more
core   +5 more sources

Physiological Dysfunction of the Dorsolateral Prefrontal Cortex in Schizophrenia Revisited [PDF]

Cerebral Cortex, 2000
Evidence implicates subtle neuronal pathology of the prefrontal cortex (PFC) in schizophrenia, but how this pathology is reflected in physiological neuroimaging experiments remains controversial. We investigated PFC function in schizophrenia using functional magnetic resonance imaging (fMRI) and a parametric version of the n-back working memory (WM ...
J H, Callicott, A, Bertolino, V S, Mattay, F J, Langheim, J, Duyn, R, Coppola, T E, Goldberg, D R, Weinberger   +7 more
openaire   +2 more sources

Electrophysiological Heterogeneity of Fast-Spiking Interneurons: Chandelier versus Basket Cells [PDF]

, 2013
In the prefrontal cortex, parvalbumin-positive inhibitory neurons play a prominent role in the neural circuitry that subserves working memory, and alterations in these neurons contribute to the pathophysiology of schizophrenia.
Povysheva, Nadezhda V., Aleksey V Zaitsev, Lewis, David A., Guillermo Gonzalez-Burgos, Lewis David A., Nadezhda V Povysheva, Zaitsev, Aleksey V., David A Lewis, Maccaferri, Gianmaria, Povysheva Nadezhda V., Gonzalez-Burgos Guillermo, Zaitsev, AV, González-Burgos, Guillermo, Lewis, DA, Povysheva, NV, Zaitsev Aleksey V., Gonzalez-Burgos, G   +16 more
core   +2 more sources

Causal relationships between brain and spinal motor neuron excitability during motor imagery: Using NIRS and evoked electromyogram study

NeuroImage: Reports, 2022
In this study, we elucidated the neural basis of motor imagery by using a powerful statistical method in addition to simultaneous brain and spinal measurements using NIRS and evoked electromyogram.
Yuki Fukumoto, Marina Todo, Hiroki Bizen, Daisuke Kimura, Toshiaki Suzuki   +4 more
doaj   +1 more source

Pharmacological Manipulation of Cortical Inhibition in the Dorsolateral Prefrontal Cortex [PDF]

Neuropsychopharmacology, 2017
Cortical inhibition (CI) occurs largely through GABA receptor-mediated inhibitory neurotransmission, which can be modulated by cholinergic, dopaminergic, and glutamatergic inputs. Transcranial magnetic stimulation (TMS) can be used to index CI through a paradigm known as long-interval CI (LICI).
Bahar, Salavati, Tarek K, Rajji, Reza, Zomorrodi, Daniel M, Blumberger, Robert, Chen, Bruce G, Pollock, Zafiris J, Daskalakis   +6 more
openaire   +2 more sources

Methamphetamine-Triggered Neurotoxicity in Human Dorsolateral Prefrontal Cortex

Galen Medical Journal, 2021
Background: Methamphetamine (MA), is an extremely addictive stimulant that adversely affects the central nervous system. Accumulating evidence indicates that molecular mechanisms such as oxidative stress, apoptosis, and autophagy are involved in the toxicity of MA.
Zare, Ali, Ghanbari, Alireza, Hoseinpour, Mohammad Javad, Eskandarian Boroujeni, Mahdi, Alimohammadi, Alimohammad, Abdollahifar, Mohammad Amin, Aliaghaei, Abbas, Mansouri, Vahid, Arani, Hamid Zaferani   +8 more
openaire   +2 more sources

Model-Based Decision Making in the Human Brain [PDF]

, 2007
Many real-life decision making problems incorporate higher-order structure, involving interdependencies between different stimuli, actions, and subsequent rewards.
Hampton, Alan Nicolás
core   +1 more source