Results 51 to 60 of about 523,044 (279)

SemanticST: A Scalable Multi‐Contextual Graph Learning Framework for Uncovering Spatial Niches and Robust Multi‐Sample Integration in Spatial Transcriptomics

Advanced Science, EarlyView.
Technical limitations often let dominant signals overshadow rare cell types and fine‐grained heterogeneity in spatial transcriptomics. SemanticST, a graph neural network using multi‐semantic graph fusion and a novel min‐cut loss, recovers these subtle patterns.
Roxana Zahedi, Ahmadreza Argha, Nona Farbehi, Ivan Bakhshayeshi, Thantrira Porntaveetus, Youqiong Ye, Nigel H. Lovell, Hamid Alinejad‐Rokny   +7 more
wiley   +1 more source

Dysbindin-1 in dorsolateral prefrontal cortex of schizophrenia cases is reduced in an isoform-specific manner unrelated to altered dysbindin-1 gene expression [PDF]

, 2009
DTNBP1 (dystrobrevin binding protein 1) remains one of the top candidate genes in schizophrenia. Reduced expression of this gene and the protein it encodes, dysbindin-1, has been reported in the dorsolateral prefrontal cortex (DLPFC) of schizophrenia ...
Natalia Louneva, Julia W. Cohen, Konrad Talbot, Chang-Gyu Hahn, Steven E. Arnold, Derek J. Blake, Junxia Tang, Lilly Yeh, Robert P. LeGros   +8 more
core  

Perceived Time Shapes Physical Fatigue Accumulation and Its Neural Oscillatory Correlates

Advanced Science, EarlyView.
Can a clock change the course of physical fatigue? By covertly manipulating the clock calibration during repeated isometric contractions, we showed that perceived time shapes fatigue accumulation and frontal oscillatory dynamics. While fatigue accumulation was only reduced when the clock was slowed down, frontal oscillatory dynamics followed perceived ...
Pierre‐Marie Matta, Julien Duclay, Robin Baurès, Andrea Alamia   +3 more
wiley   +1 more source

Problem gamblers share deficits in impulsive decision-making with alcohol-dependent individuals [PDF]

, 2009
Aims: Problem gambling has been proposed to represent a ‘behavioural addiction’ that may provide key insights into vulnerability mechanisms underlying addiction in brains that are not affected by the damaging effects of drugs.
Lawrence, AJ, Bogdan, Nadine A., Nadine A. Bogdan, Barbara J. Sahakian, Lawrence, Andrew J.; id_orcid, Andrew J. Lawrence, Clark, Luke, Clark, L, Jason Luty, Luty, Jason, Luke Clark, Luty, J, Bogdan, NA, Sahakian, BJ, Sahakian, Barbara J.   +14 more
core   +1 more source

Tau Aggregate Imaging and Transcriptomics of Alzheimer's Disease Brain at Different Stages of Disease

Advanced Science, EarlyView.
The protein aggregates and gene expression in the middle temporal gyrus (MTG) and somatosensory cortex (SOM) of the postmortem brains of 13 Alzheimer's disease patients were studied in detail, revealing that small hyperphosphorylated tau aggregates increase with Braak stage driven by microglial inflammation.
Elizabeth A. English, Dorothea Böken, Matthew W. Cotton, Matthew R. Cheetham, Johanna S. Jackson, Georg Meisl, John S. H. Danial, Paul M. Matthews, Nurun N. Fancy, David Klenerman   +9 more
wiley   +1 more source

Cough is dangerous:Neural correlates of implicit body symptoms associations

Frontiers in Psychology, 2016
The negative interpretation of body sensations (e.g., as sign of a severe illness) is a crucial cognitive process in pathological health anxiety (HA). However, little is known about the nature and the degree of automaticity of this interpretation bias ...
Daniela eMier, Michael eWitthöft, Josef eBailer, Julia eOfer, Tobias eKerstner, Fred eRist, Carsten eDiener   +6 more
doaj   +1 more source

Time course of functional connectivity in primate dorsolateral prefrontal and posterior parietal cortex during working memory. [PDF]

PLoS ONE, 2013
The dorsolateral prefrontal and posterior parietal cortex play critical roles in mediating attention, working memory, and executive function. Despite proposed dynamic modulation of connectivity strength within each area according to task demands, scant ...
Fumi Katsuki, Christos Constantinidis
doaj   +1 more source

Integration of auditory and visual communication information in the primate ventrolateral prefrontal cortex [PDF]

, 2006
The integration of auditory and visual stimuli is crucial for recognizing objects, communicating effectively, and navigating through our complex world.
Tadashi Sugihara, Mark D. Diltz, Sugihara, T, Averbeck, BB, Romanski, LM, Lizabeth M. Romanski, Diltz, MD, Bruno B. Averbeck   +7 more
core  

Cell adhesion molecule expression in the dorsolateral prefrontal cortex and anterior cingulate cortex in major depression in the elderly

, 2002
Background Neuroimaging studies have demonstrated changes in the dorsolateral prefrontal cortex (DLPFC) and anterior cingulate cortex (ACC) in major depression.
Sue Davis, Rajesh N. Kalaria, John T. O'Brien, Alan J. Thomas, I. Nicol Ferrier   +4 more
core   +1 more source

Molecular Glue Degraders Enhance CAPRIN1‐Dependent Lysosomal Degradation of APP and Reduce Amyloid β in Alzheimer's Disease

Advanced Science, EarlyView.
A new class of lysosome‐directed molecular glue degraders selectively enhance CAPRIN1–APP interactions, driving APP degradation and reducing amyloid‐β production in human neurons and Alzheimer's disease mouse models. This CAPRIN1‐dependent targeted protein degradation strategy reveals a previously unrecognized therapeutic approach for disrupting the ...
Sunghan Jung, Xu Wang, Bin Liu, Raktim Roy, Nancy Jaiswal, Ratan K. Rai, Yuichiro Takagi, Cen Gao, Lifan Zeng, Ho‐Yin Lo, Reagan K. Wohlford, Ryan K. Higgins, Bruce T. Lamb, Anantha Shekhar, Anita C. Bellail, Chunhai Hao   +15 more
wiley   +1 more source