Results 41 to 50 of about 50,446 (325)

Physical Mechanisms Shaping the Drosophila Dorsoventral Compartment Boundary [PDF]

Current Biology, 2012
Separating cells with distinct identities and fates by straight and sharp compartment boundaries is important for growth and pattern formation during animal development. The physical mechanisms shaping compartment boundaries, however, are not fully understood.We combine theory and quantitative experiments to investigate the roles of different ...
Maryam Aliee, Jens-Christian Röper, Katharina P. Landsberg, Constanze Pentzold, T. Widmann, F. Jülicher, Christian Dahmann   +6 more
semanticscholar   +4 more sources

Linear signaling in the Toll-Dorsal pathway of Drosophila: activated Pelle kinase specifies all threshold outputs of gene expression while the bHLH protein Twist specifies a subset [PDF]

, 2002
Differential activation of the Toll receptor leads to the formation of a broad Dorsal nuclear gradient that specifies at least three patterning thresholds of gene activity along the dorsoventral axis of precellular embryos.
Levine, Michael, Stathopoulos, Angelike
core  

Multifunctional Neural Probes Enable Bidirectional Electrical, Optical, and Chemical Recording and Stimulation In Vivo

Advanced Materials, EarlyView.
Convergence drawing is used to create flexible, microscale, multifunctional fiber‐based neural probes. Optimized materials selection enables individual devices to perform neural recording, electrical stimulation, optogenetics, fiber photometry, fluid delivery, and voltammetric neurotransmitter detection in rodents.
Nicolette Driscoll, Marc‐Joseph Antonini, Taylor M. Cannon, Pema Maretich, Greatness Olaitan, Valerie Doan Phi Van, Keisuke Nagao, Atharva Sahasrabudhe, Emmanuel Vargas Paniagua, Ethan J. Frey, Ye Ji Kim, Sydney Hunt, Melissa Hummel, Sanju Mupparaju, Alan Jasanoff, B. Jill Venton, Polina Anikeeva   +16 more
wiley   +1 more source

The GLP1R Agonist Semaglutide Inhibits Reactive Astrocytes and Enhances the Efficacy of Neural Stem Cell Transplantation Therapy in Parkinson's Disease Mice

Advanced Science, EarlyView.
Compared to transplantation of neural stem cells (NSCs) alone, the combined treatment of NSCs with semaglutide more effectively improves motor dysfunction in Parkinson's disease (PD) mice. This synergistic effect may result from semaglutide's ability to suppress microglial activation, thereby preventing the transformation of resting astrocytes into ...
Dan Song, Xiaoya Zou, Di Ma, Yuying Zhao, Tingting Liu, Bibiao Shen, Oumei Cheng   +6 more
wiley   +1 more source

Diagnosis of dental problems in pet rabbits (Oryctolagus cuniculus) [PDF]

, 2008
Dental problems are very common in pet rabbits. To establish a correct diagnosis of rabbit dental pathology, a general knowledge of normal dental anatomy and physiology is necessary.
De Rycke, Lieve, Gielen, Ingrid, Hermans, Katleen, van Bree, Henri, Van Caelenberg, Annemie, Verhaert, Leen   +5 more
core   +1 more source

Laminar and Dorsoventral Molecular Organization of the Medial Entorhinal Cortex Revealed by Large-scale Anatomical Analysis of Gene Expression

PLoS Comput. Biol., 2015
Neural circuits in the medial entorhinal cortex (MEC) encode an animal’s position and orientation in space. Within the MEC spatial representations, including grid and directional firing fields, have a laminar and dorsoventral organization that ...
Helen L. Ramsden, Gülşen Sürmeli, Steven G. McDonagh, M. Nolan   +3 more
semanticscholar   +1 more source

An Amygdala‐hippocampus Circuit for Endocannabinoid Modulation of Anxiety Avoidance

Advanced Science, EarlyView.
This study employs three synapse‐specific endocannabinoids (eCB) probes to monitor dynamic eCB release, activate CB1Rs and knockdown 2‐AG biosynthesis enzymes in glutamatergic anterior basolateral amygdala ‐ ventral hippocampus (aBLA–vHPC) circuit. At aBLA–vHPC circuits, activation of CB1Rs reduce anxiety avoidance, and knockdown of eCB biosynthesis ...
Bao Xue, Mao‐Xing Zhang, Xiao‐Chen Bi, Shou‐Peng Lai, Xin‐Tian Bie, Yuan Dong, Jian‐Feng Li, Fang Gao, Xia Zhang, Ying Wang   +9 more
wiley   +1 more source

The Selector Gene apterous and Notch Are Required to Locally Increase Mechanical Cell Bond Tension at the Drosophila Dorsoventral Compartment Boundary

PLoS ONE, 2016
The separation of cells with distinct fates and functions is important for tissue and organ formation during animal development. Regions of different fates within tissues are often separated from another along straight boundaries.
Marcus Michel, Maryam Aliee, Katrin Rudolf, Lisa Bialas, F. Jülicher, Christian Dahmann   +5 more
semanticscholar   +1 more source

Green‐to‐red spectral labeling: A novel polysynaptic retrograde tracing strategy in the marker footprint mouse model

Animal Models and Experimental Medicine, EarlyView.
To compensate for the fluorescence loss in rabies virus–derived neuronal tracing tools caused by non‐cytolytic immune clearance (NCLIC) in retrograde tracing, we developed a novel green‐to‐red spectral labeling (GTR) strategy based on the NCLIC phenomenon and developed a novel marker footprints mouse to support the strategy.
Yige Song, Jinyu Zeng, Yunyun Han, Aodi He, Houze Zhu   +4 more
wiley   +1 more source

Visual search and decision making in bees: time, speed and accuracy [PDF]

, 2006
An insect searching a meadow for flowers may detect several flowers from different species per second, so the task of choosing the right flowers rapidly is not trivial.
Chittka, L, Skorupski, P, Spaethe, J
core   +2 more sources